Name and Surname: Anna Cociurovscaia

Supervisor: Prof. dr hab. inż. Grzegorz Bujacz

Second supervisor: Dr inż. Agnieszka Pietrzyk-Brzezińska
Faculty: Faculty of Biotechnology and Food Sciences
Institute: Institute of Molecular and Industrial Biotechnology

Title of the doctoral dissertation: Structural studies of two-component

signal transduction systems in bacteria Escherichia coli

Two-component signal transduction systems (TCSs) are cell signaling

circuits that take part in adaptation to environmental changes, regulation of
metabolism pathways, virulence, antibiotic resistance, and many other
processes. Studies on the Escherichia coli TCSs provide the data essential
to understand the relations between basic biological processes of a model
organism and its external conditions. The knowledge about protein
structures gives a unique opportunity to explore mechanisms which
regulate the phosphorelay pathway of two-component systems and their
role in gene expression. The aim of the study is to determine structures of
two Escherichia coli TCSs, which are involved in response to the presence
of hydrogen peroxide, copper or another metals in cel environment.