Topic : Acute

Osteomyelitis

Prepared by : Yubin Pokharel

Roll no: 100
(MBBS 1st year)
Approved by :

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 Objective

Explain the etiopathogenesis of acute osteomyelitis.

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Etiopathogenesis of Acute Osteomyelitis
Causative agents

Mode of spread
• Hematogenous spread ; vertebrae most common site and metaphysis of long
bone.
• Extension from contiguous site; previous surgery, wound, or poor vascularity
• Direct implantation ; traumatic injury or surgical contamination
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Pathogenesis

• Affect mainly metaphyseal region of

long bone.
• Bacteria gain access through nutrient
arteries.

• Common reason for metaphyseal

osteomyelitis
• Hairpin bend vessels
• Pooling of blood due to increased
vascularity.
• Immature cells
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Pathogenesis (cascade of events)

Infection begins at the metaphyseal end of marrow cavity and is filled with pus.

Tension in the marrow cavity rises due to pus and results in spread of infection.

Infection reaches the subperiosteal spaces subperiosteal abscesses are formed.

Combination of suppuration and impaired blood supply to cortical bone results

in erosion.
Thinning and infraction necrosis of the cortex i.e. called sequestrum.
New bone formation beneath periosteum encasing necrosed bone i.e. called
involucrum.
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Summary

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Reference
ROBBINS and COTRAN PATHOLOGIC BASIS OF DISEASES (10th edition )

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 Thank you
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