Human papillomavirus (HPV) is a member of the papillomavirus, family of viruses that is capable of infecting humans. Like all papillomaviruses, HPVs establish productive infections only in keratinocytes of the skin or mucous membranes.

‡ While the majority of the nearly 200 known types of HPV cause no symptoms in most people, some types can cause warts (verrucae), while others can in a minority of cases lead to cancers of the cervix, vulva, vagina, and anus in women or cancers of the anus and penis in men. It can also cause cancers of the head and neck (tongue, tonsils and throat).

349 die of the disease. b. Five out of 10 Filipino women with cervical cancer will die within five years. Approximately.a. 12 Filipino women die each day due to cervical cancer.000 Filipinas are diagnosed with cervical cancer and 4.The number of Filipino women diagnosed with cervical cancer remains high. Cervical Cancer MANILA. Anal Cancer . Philippines . an estimated 6. Every year.

-Noncancerous skin growths -Infection with these types of HPV causes a rapid growth of cells on the outer layer of the skin .

. .Types of warts include: a. Common warts Some "cutaneous" HPV types cause common skin warts. such as the elbows or knees. but can also occur in other areas. Common warts are often found on the hands and feet.

Common warts have a characteristic cauliflower-like surface and are typically slightly raised above the surrounding skin. Cutaneous HPV types can cause genital warts but are not associated with the development of cancer .


Plantar warts  found on the soles of the feet. .b. Plantar warts grow inward. generally causing pain when walking.


. They may be more difficult to treat than warts in other locations. Subungual or periungual warts form under the fingernail (subungual).‡ c. around the fingernail or on the cuticle (periungual).


flat warts occur most frequently in children and teens. face or forehead. . flat warts are not associated with the development of cancer. In people with normal immune function.d. Like common warts. Flat warts  Flat warts are most commonly found on the arms.


flat. and plantar warts are much less likely to spread from person to person.Genital warts are quite contagious.. . while common.

.-Genital or anal warts (condylomata acuminata or venereal warts) are the most easily recognized sign of genital HPV infection.


People may transmit the virus to others even if they do not display overt symptoms of infection. .-Most people who acquire genital wartassociated HPV types clear the infection rapidly without ever developing warts or any other symptoms.

. Since an individual can be infected with multiple types of HPV.-HPV types that tend to cause genital warts are not those that cause cervical cancer. the presence of warts does not rule out the possibility of high-risk types of the virus also being present.

. such as the hands or inner thighs.-The types of HPV that cause genital warts are usually different from the types that cause warts on other parts of the body.

in which warts form on the larynx or other areas of the respiratory tract. .‡ RESPIRATORY PAPILLOMATOSIS -HPV types 6 and 11 can cause a rare condition known as recurrent respiratory papillomatosis.


-These warts can recur frequently. may require repetitive surgery. and in extremely rare cases can progress to cancer. . may interfere with breathing.

. The virus. causes the overproduction of keratin by skin cells.‡ IN THE IMMUNOCOMPROMISED .In very rare cases. resulting in lesions resembling warts or cutaneous horns. HPV may cause epidermodysplasia verruciformis in immunocompromised individuals. unchecked by the immune system.

. Attempted treatment by both Indonesian and American doctors included surgical removal of the warts. an Indonesian man developed warts that spread across his body and became root-like growths. Dede Koswara. .For instance.

Epidermodysplasia verruciformis .

Perinatal transmission of HPV types 6 and 11 can result in the development of juvenileonset recurrent respiratory papillomatosis (JORRP). .‡ Prenatal Sometimes transmitted from mother to child during birth. the appearance of genital HPVrelated diseases in newborns is rare.

‡ Genital Infection HPV infections are transmitted primarily via sexual activity. .

Example: If a college woman has at least one different partner per year for four years. thus exposing these areas to the infected person s skin. the probability that she will leave college with an HPV infection is greater than 85%. . Condoms do not completely protect from the virus because the areas around the genitals including the inner thigh area are not covered.

Fingers-genital contact is a possible way of transmission but unlikely to be a significant source. . Although possible.‡ Shared objects Sharing of possibly-contaminated objects may transmit HPV. transmission by routes other than sexual intercourse is less common for female genital HPV infection.

‡ Cutaneous HPVs Infection with cutaneous HPVs is ubiquitous. such as HPV-5. Some HPV types. may establish infections that persist for the lifetime of the individual without ever manifesting any clinical symptoms. .

Skin warts are most common in childhood and typically appear and regress spontaneously over the course of weeks to months. Other cutaneous HPVs. may cause common warts in some infected individuals. .. such as HPV types 1 or 2.

immunological control is thought to block the appearance of symptoms such as warts. Although these latent infections may never be fully eradicated. About 10% of adults also suffer from recurring skin warts.  All HPVs are believed to be capable of establishing long-term "latent" infections in small numbers of stem cells present in the skin. .

.Immunological control is HPV type-specific. meaning that an individual may become resistant to one HPV type while remaining susceptible to other types.

.‡ Genital HPVs A large increase in the incidence of genital HPV infection occurs at the age when individuals begin to engage in sexual activity. The great majority of genital HPV infections never cause any overt symptoms and are cleared by the immune system in a matter of months.

Lingering infection with high-risk HPV types. 18. can lead to the development of cervical cancer or other types of cancer . and 45. such as HPVs 16.As with cutaneous HPVs. 31. immunity is believed to be HPV type-specific. Some infected individuals may fail to bring genital HPV infection under immunological control.

. epidemiological and molecular data suggest that co-factors such as the cigarette smoke carcinogen benzo[a]pyrene (BaP) enhance development of certain HPVinduced cancers.In addition to persistent infection with highrisk HPV types.

. penile cancers.High-risk HPV types 16 and 18 are together responsible for over 65% of cervical cancer cases. Type 16 causes 41 to 54% of cervical cancers. and accounts for an even greater majority of HPV-induced vaginal/vulvar cancers. anal cancers and head and neck cancers.

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