Nano medicine can be defined as the monitoring, repairing, construction and control of human biological systems at the cellular

level by using materials and structures engineered at the atomic or molecular level Aiming to trigger endogenous self repair mechanism.

 This could lead to personalised treatment Targeted delivery systems and assisted

regenerative medicine. Targeted delivery agents will allow localised therapy.&reduced unwanted side affects.
It is based on imaging. Here nanotechnology will lead to

miniaturisation of devices that enable minimally invasive procedures and new ways to treatment

 In most cases the formation of a plaque in blood vessels ,it leads to stenosis of blood vessels  The plaque becomes unstable & ruptured ,death or disability are consequence  Target agents therapeutic payload that stabilises and prevents rupture.  New treatments include nano biomaterials with the ability to attract adult stem cells or culture cells to site of injury and improve heart function.

Late stage metastatic cancer is difficult to cure and treatment leaves severe side affects suffers patient and high cost. Nanotechnology could enable the in-vitro measurements of many biomarkers at the same time keeping itself simple and reliable . Ex: already in clinical use is an antibody is either labelled with radioactive isotope for single photon emmission computed tomography imaging which efficiently kills metastases through out body

 Clinical symptoms are pain &functional impairment induce

joint stiffness & dysfunction with subsequent impaired performances.  Osteoarthritis & osteochondrosis induce a severe process of inflammation which results in a dramatic increase in the degenerative process .  Nano assisted regenerative medicine treatments include diseases modifying therapies with bioactive molecules coupled to biomaterials based on nano structures locally implanted in area of injury or a systemic target approach both aiming at recruit ing attracting and stimulating local stem cells for local repair.  Other treatments could be the delivery of nanoparticles selectively attach to stem cells niches and releasing local stimulating factors this treatment might allow repair of articular cartilage and regain homeostatis with in joints

 This diseases are slowly progressive and difficult to detect, inresponsiveness to therapy in particular new types nanoagents may be transported through blood brain barrier regenerative medicine holds to the remarkable promise to only treat symptoms but also restore function  Nano carriers with special surface properties may offer new and efficient options to carry a therapeutic pay load through blood brain barrier

In vivo imaging In vitro imaging Medical devices

Liposomes Micellular & micro-emulsion systems Liquid crystal based formulations Nanocrystals Antibodies & conjuates Delivery of small nucleic acids or mimetics Delivery of vaccines

Are defined as those molecules which are naturally present in cells(cytokines,growth factors,receptors,2nd messangers)& trigger regenerative events at the cellular level. Bioactive molecules as therapeutic agents could be incorporated in the degradable taiolered scaffolds to be delivered in a controlled manner.

Cellular differention occurs in mammales at embryological development&normal cell turnover or repair following injury. Cellular turnover is fast in certain tissues,such as intestetial epithelium,blood& epidermis. The major goal of on going and future efforts to discovered self repair potential.

Liposomal Drug Delivery in Breast Cancer

Diffusion

Endocytosis