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NEUROSCIENCE II:
EVOLUTION AND
FUNCTION OF THE
BRAIN AND
NERVOUS SYSTEMS
Prepared by
Brenda Leady, University of Toledo
1 reprod
Copyright (c) The McGraw-Hill Companies, Inc. Permission required for
Nervous system is the product of
hundreds of millions of years of evolution
Development provided advantages that
promoted reproductive success
Organization ranges from simple network
of a few cells to complexity of human brain
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Representative nervous systems
Except for sponges,
all animals have a
nervous system
Nerve net
Simplest nervous
system
Cnidarians (jellyfish,
hydras, anemones)
Neurons connect to
each other in a
network 3
Echinoderms
Slightly more sophisticated
Nerve ring around mouth
connected to larger radial
nerves extending to arms
Planaria
Nerve cords extend length
of animal connected by
transverse nerves
Collection of neurons in
head form ganglia
Perform basic integration
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Annelids
Same basic structure
More neurons
Ventral nerve cords
have ganglia in each
segment
Simple mollusks
Similar to annelids
Pair of anterior ganglia
Paired nerve cords
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Trend toward
cephalization –
increasingly complex
brain in the head
Drosophila
Brainhas several
subdivisions with
separate functions
Advanced mollusks
Brains with well-
developed
subdivisions
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Vertebrates and
simpler chordates
have a CNS (brain
and spinal cord)
and PNS
Organization
shows similarities
to segmentation of
invertebrates
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3 divisions of vertebrate brain
Entire nervous system develops from
neural fold in embryo
Hindbrain
Metencephalon
Myelencephalon
Midbrain
Mesencephalon
Forebrain
Telencephalon
Diencephalon
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Hindbrain
Medulla oblongata – coordinates many basic
reflexes and bodily functions
Pons and cerebellum – responsible for
monitoring and coordinating body movements
Midbrain
Processes several types of sensory input
Controls sophisticated tasks
Forebrain
Higher functions of conscious thought,
planning and emotion
Cerebrum
Cerebral cortex – outer layer of cerebrum
Thalamus and hypothalamus
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Increased brain complexity
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Body mass and brain mass proportional
with exceptions (humans and dolphins)
Greater size and folding provides more
surface area for greater processing and
interpretation of information
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Human nervous system
Central nervous system (CNS)
Brain and spinal cord
Peripheral nervous system (PNS)
Neurons and axons of neurons outside the
CNS
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Nucleus – cell bodies of neurons involved
in a similar function in the CNS
Ganglion – similar structure in PNS
Tract – myelinated axons that run in
parallel bundles in the CNS
Nerves – similar structure in PNS
Cranial nerves are connected directly to
the brain
Spinal nerves are connections between
the PNS and spinal cord
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White matter
Myelinated axons grouped together
Gray matter
Neuronal cell bodies, dendrites and some
unmyelinated axons
Spinal cord gray matter forms
Dorsal horns – connects to dorsal root, part
of spinal nerve, incoming information
Ventral horns – connects to ventral root,
part of spinal nerve, outgoing information
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CNS encased in bone and 3 layers of
meninges
Dura mater – outer thick layer
Arachnoid mater – numerous connections
to inner layer
Pia mater – inner thin membrane on
surface of brain and spinal cord
Cerebrospinal fluid circulated through
subarachnoid space
Between arachnoid mater and pia mater
Absorbs physical shocks
Transport
Ventricles and central canal
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PNS divisions
Somatic nervous system
Sensory neurons (afferent) receive stimuli such as
heat, vision, smell, taste, hearing, touch and transmit
to CNS
Motor neurons (efferent) control skeletal muscles –
voluntary
Autonomic nervous system
Predominantly composed of motor neurons (efferent)
control smooth muscles, cardiac muscles and glands
– involuntary
Sensory neurons (afferent) detect internal body
conditions
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Efferent nerves of autonomic further divided
Act on same organs with opposing actions
Sympathetic division
“fight
or flight”
Increased heart rate, faster breathing
Parasympathetic division
“rest
and digest”
Slow heart rate, promote digestion
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Hindbrain
Medulla oblongata
Coordinates many basic reflexes and bodily
functions that maintain the normal
homeostatic processes of a person
Involved in the control of heart rate, breathing,
cardiovascular function, digestion, swallowing,
and vomiting
With pons and areas of the midbrain,
collectively called the brainstem, contain
additional nuclei (groups of cell bodies) whose
axons project dorsally to many other parts of
the brain
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Hindbrain
Cerebellum and pons
Responsible for monitoring and coordinating
body movements
Pons serves as relay between cerebellum and
other areas of the brain
Overall function of cerebellum to maintain
balance and coordinate hand-eye movements
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Midbrain
Forms part of the reticular formation
Processes several types of sensory
inputs, including vision, smell, and hearing
Tracts that pass this information to other
parts of the brain for further processing
and interpretation
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Forebrain
Thalamus and
hypothalamus
(diencephalon)
Cerebrum
(telencephalon) –
basal nuclei, limbic
system and cerebral
cortex
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Forebrain
Thalamus
Major role in relaying sensory information to
appropriate parts of the cerebrum and, in turn,
sending outputs from the cerebrum to other parts of
the brain
Receives input from all sensory systems
Hypothalamus
Major role of production of hormones regulating
pituitary gland which regulates hormone secretion
from other glands
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Forebrain
Basal nuclei
Involved in planning and learning movements
Involved in initiating or inhibiting movements
Affected in Parkinson disease
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Limbic system
Not all agree on members of limbic system
Primarily involved in formation and expression of
emotions
Role in learning, memory, and perception of smells
Amygdala – understand and remember emotional
situations, recognize emotional expressions in others
Hippocampus – establish memories for spatial
locations, facts, and sequences of events
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Forebrain
Cerebral cortex
Surface layer of gray matter on the cerebrum
Neocortex layer evolved most recently in
mammals with only 6 layers of cells
Contains 10% of neurons in the brain
Sensory and motor information integrated
Initiation of voluntary acts, generation of
speech, learning, memory, and production of
emotions
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Frontal – conscious thought and social
awareness
Parietal – attention and making association
between events and incoming information
Occipital – vision
Temporal – language, learning, and some
types of memory
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Sensory inputs come
into the cortex and
motor outputs leave
the cortex in areas
that stretch like a map
Amount of space
proportional to
sensitivity or number
of muscles
May change
depending on use or
disuse of body part
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Cerebral hemispheres connected by
corpus collosum
Severing connection used in the past to
treat severe epilepsy
Hemispheres can function independently
Process different types of information
Left hemisphere – understanding
language and producing speech
Right hemisphere – nonverbal
memories, recognizing faces, and
interpreting emotions
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Several Genes Have Been Important in the
Evolution of the Cerebral Cortex
Genes identified by studying developmentally
disabled individuals or comparing human genes to
other species
Polymicrogyria – results in mental impairment,
disrupted gait and language production
Abnormal surface folds and fewer layers of cells
Mutations alter receptors’ ability to bind ligand
Microcephalin and ASPM genes
Determinants of brain size
May be involved in brain evolution – greater changes in
humans and great apes
Learning and memory
Learning – process by which new information is
acquired
Memory – involves retention of that information
over time
Long-term potentiation (LTP)
Long-lasting strengthening of connections between
neurons
Experiments with rabbits showed short, electrical
stimulations to a neuron strengthened synapses with
adjacent cells
Neurons communicated more readily
40
Work with California
sea slug (Aplysia
californica)
Has only 20,000
nerve cells
Some neurons
extremely large
Can isolate proteins
and mRNA to identify
biochemical and
genetic changes
during learning
Gill-withdrawal reflex
subject to learning
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Sea slugs process in 2 phases
Short-term memory lasts for minutes or hours
Typically single stimulus
No new proteins
Intracellular second messengers make it easier for
neurons to communicate
Long-term memory lasts days or weeks
Repeated stimuli
Activates genes, leads to mRNA synthesis, new
proteins for additional synaptic connections
Learning does not change neuron pathways but
changes strength of signals along those
pathways
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Neurogenesis
Until recently, adult brain thought incapable of
producing new neurons through cell division
Late 1990s, stem cells found in primate and
human CNS
1998, found new hippocampal cells in recently
deceased patients
Some evidence suggests that neurogenesis is
involved in learning and memory
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Brain images in assessment
Computerized tomography (CT) scan – 3D
image based on density but not great detail
Magnetic Resonance Imaging (MRI) – detection
of structures as small as 1/10th mm
Function MRI (fMRI) – modification to assess
functional activity based on oxygen in active
tissue
Oxygenated hemoglobin increases in metabolically
active areas
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Gaser and Schlaug Showed That the Sizes of
Certain Brain Structures Differ Between Musicians
and Nonmusicians
Used MRI to examine sizes of brain structures in
professional musicians, amateur musicians, and
nonmusicians
Brain areas involved in hearing, moving the fingers, and
coordinating movements with vision and hearing were
larger in professional musicians than in amateur
musicians, and larger in amateurs than in nonmusicians
Have not determined underlying reason(s) for increased
brain size
People with increased brain size in these areas may be more likely
to become musicians or musical training may cause these areas to
enlarge
Impact on public health
Meningitis
Viral or bacterial infection of meninges
Increased pressure effects range from severe
headaches to death
Bacterial infection can be treated with antibiotics
Viral form less serious and short lasting
Vaccine has reduced cases but still dangerous and
prevalent disease (especially close quarters like
college dorms)
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Alzheimer’s disease (AD)
Leading worldwide cause of dementia
Characterized by memory loss and intellectual and
emotional function
Definitive diagnosis can only be made after death
2 noticeable changes – senile plaques and
neurofibrillary tangles
Not clear how changes influence function
Genetics plays a role but not the only possible cause
Impact on public health enormous – especially as
baby boomers age
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