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National Institutes of Health Search termSearch database All DatabasesPubMedProteinNucleotideGSSESTStructureGenomeAssemblyBioProjectBioSa mpleBioSystemsBooksConserved DomainsClonedbGaPdbVarEpigenomicsGeneGEO DataSetsGEO ProfilesHomoloGeneMeSHNCBI Web SiteNLM CatalogOMIAOMIMPMCPopSetProbeProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMed HealthSNPSRATaxonomyToolKitToolKitAllUniGeneUniS TS Search Advanced Help Result Filters Display Settings:AbstractSend to: Minerva Anestesiol. 1990 Nov;56(11):1413-7. [Use of atracurium for the prevention of fasciculations and succinylcholine myalgia in athletes undergoing orthopedic surgery]. [Article in Italian] Pagani I, Ramaioli F, Albertario F, Mora R, Dionigi RV. Source Servizio di Anestesia e Rianimazione II, I.R.C.C.S. Policlinico S. Matteo, Pavia . Abstract The Authors report their clinical experience about the use of atracurium besylate in preventing succinylcholine-induced fasciculations and postoperative myalgias in fifty athletes (ASA class 1), submitted to arthroscopic meniscectomy . The patients were pretreated with atracurium 5 mg i.v. or saline solution in a double-blind fashion. After 2.5 minutes, succinylcholine 1.3 mg/kg was administered, and fasciculations were recorded on a scale ranging from 0 to 3. Twenty-four hours after surgery all subjects were questioned about myalgias occurrence, scored by a 0-3 scale. Fasciculations occurred in all patients who

received saline and in 44% of those treated with atracurium. Myalgias on the postoperative day were observed in 80% of patients treated with saline solution, but only in 36% of patients who received atracurium. The difference between atracurium and saline solution was statistically significant (p less than 0.001) either for fasciculations or myalgias incidence. These findings show that atracurium 5 mg i.v. is effective in preventing succinylcholine-induced fasciculations and postoperative myalgias, and suggest atracurium as the drug of choice for this purpose, particularly in muscular subjects. PMID: 2084590 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, Substances LinkOut - more resources Supplemental Content Save items Add to Favorites View more options Related citations in PubMed Effectiveness of atracurium in preventing succinylcholine myalgia. [AANA J. 1989] Effects of pretreatment with cisatracurium, rocuronium, and d-tubocurarine on succinylcholine-induced fasciculations and myalgia: a comparison with placebo. [J Clin Anesth. 1999] Comparison of atracurium and d-tubocurarine for prevention of succinylcholine myalgia. [Anesth Analg. 1987] Evaluation of succinylcholine-induced fasciculations and myalgias with or without atracurium pretreatment. [AANA J. 1996] Review Succinylcholine-associated postoperative myalgia. [Anaesthesia. 2000] See reviews... See all... Related information Related Citations Compound

Compound (MeSH Keyword) Substance Substance (MeSH Keyword) Recent activity Clear Turn Off [Use of atracurium for the prevention of fasciculations and succinylcholine myal ... PubMed Myalgia and biochemical changes following suxamethonium after induction of anaes ... PubMed Differential effects of neuromuscular blocking agents on suxamethonium-induced f ... PubMed Calcium gluconate pretreatment for prevention of succinylcholine-induced myalgia ... PubMed Comparison of rocuronium and vecuronium pretreatment for prevention of fascicula ... PubMed See more... You are here: NCBI > Literature > PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials Resources Chemicals & Bioassays Data & Software

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