Lampiran A Daftar Nama dan Struktur Anti-HSV 1 Tabel II.

4 Obat-Obat Anti-HSV1 Obat Asiklovir Nama IUPAC 2-Amino-1 !"i#i"ro-!-$$2#%"ro&%et#o&% ' metil' -( Hpurin-6 2-amino-!*+$1 ,"i#%"ro&%-roan-2-il' o&%. metil/ -( !"i#i"ro-, Hpurin-6 2-amino-!-+4#%"ro&%-,$#%"ro&%met#% l' butil. -( !"i#i"ro-,H-urin-( Struktur

)ansiklovir

Pensiklovir

,1

Lampiran A (lanjutan) Valasiklovir 2 - +$2-amino-(okso-( !-"i#i"ro,H--urin-!-il' metoksi. etil $2S'2-amino-,met#%lbutanoate

0amsiklovir

2 - +$a1et%lo&%' metil. -4 - $2amino-! H-purin9-il) butil asetat

0oskarnet

asam -#os-#ono2ormi1

,2

Lampiran B Data Hasil Pemodelan 2D dan D Tabel V.1 3ata struktur 23 "an ,3 anti-HSV1 No 1 Sen%a4a Asiklovir 23 ,3

0amsiklovir

)ansiklovir

Lampiran B (lanjutan)

,,

Pensiklovir

Valasiklovir

0oskarnet

Lampiran ! Data Hasil Docking Tabel V.4 3ata #asil Docking ,4

)ri" min $& % 6' 7 -2.58519 2.9:9:( -,.49541 )ri" ma& $& % 6' 7 :.4!492 12.9:99 (.5145! Sen%a4a Asiklovir Nilai ;<S3 v"= ra"ius C > 1.! an?strom v"= ra"ius N > 1.9 an?strom v"= ra"ius O > 1.: an?strom v"= ra"ius 0 > 1.5 an?strom v"= ra"ius P > 2.1 an?strom v"= ra"ius S > 2 an?strom v"= ra"ius Cl > 1.9 an?strom v"= ra"ius @r > 2 an?strom v"= ra"ius I > 2.2 an?strom v"= ra"ius metals > 1.2 an?strom v"= ra"ius H > 1.2 an?strom v"= ra"ius O 4ater > 1.: an?strom Best Ligand Pose ener?i > -4.829!: k1alAmol

Lampiran ! (lanjutan) 0amsiklovir v"= ra"ius C > 1.! an?strom ,5 -ose 8 2itness > (.,!1!! k1alAmol

v"= ra"ius N > 1.9 an?strom v"= ra"ius O > 1.: an?strom v"= ra"ius 0 > 1.5 an?strom v"= ra"ius P > 2.1 an?strom v"= ra"ius S > 2 an?strom v"= ra"ius Cl > 1.9 an?strom v"= ra"ius @r > 2 an?strom v"= ra"ius I > 2.2 an?strom v"= ra"ius metals > 1.2 an?strom v"= ra"ius H > 1.2 an?strom v"= ra"ius O 4ater > 1.: an?strom v"= ra"ius all ot#er atoms > 1.! an?strom

Lampiran ! (lanjutan) )ansiklovir v"= ra"ius C > 1.! an?strom ,( ener?i > -4.,9!!: k1alAmol

v"= ra"ius N > 1.9 an?strom v"= ra"ius O > 1.: an?strom v"= ra"ius 0 > 1.5 an?strom v"= ra"ius P > 2.1 an?strom v"= ra"ius S > 2 an?strom v"= ra"ius Cl > 1.9 an?strom v"= ra"ius @r > 2 an?strom v"= ra"ius I > 2.2 an?strom v"= ra"ius metals > 1.2 an?strom v"= ra"ius H > 1.2 an?strom v"= ra"ius O 4ater > 1.: an?strom v"= ra"ius all ot#er atoms > 1.! an?strom

Lampiran ! (lanjutan)

Pensiklovir

v"= ra"ius C > 1.! ,:

ener?i

an?strom v"= ra"ius N > 1.9 an?strom v"= ra"ius O > 1.: an?strom v"= ra"ius 0 > 1.5 an?strom v"= ra"ius P > 2.1 an?strom v"= ra"ius S > 2 an?strom v"= ra"ius Cl > 1.9 an?strom v"= ra"ius @r > 2 an?strom v"= ra"ius I > 2.2 an?strom v"= ra"ius metals > 1.2 an?strom v"= ra"ius H > 1.2 an?strom v"= ra"ius O 4ater > 1.: an?strom v"= ra"ius all ot#er atoms > 1.! an?strom

> -5.8!98: k1alAmol

Lampiran ! (lanjutan)

Valasiklovir

v"= ra"ius C > 1.! ,9

ener?i

an?strom v"= ra"ius N > 1.9 an?strom v"= ra"ius O > 1.: an?strom v"= ra"ius 0 > 1.5 an?strom v"= ra"ius P > 2.1 an?strom v"= ra"ius S > 2 an?strom v"= ra"ius Cl > 1.9 an?strom v"= ra"ius @r > 2 an?strom v"= ra"ius I > 2.2 an?strom v"= ra"ius metals > 1.2 an?strom v"= ra"ius H > 1.2 an?strom v"= ra"ius O 4ater > 1.: an?strom v"= ra"ius all ot#er atoms > 1.! an?strom

> -,.58(11 k1alAmol

Lampiran ! (lanjutan)

,!

0oskarnet

v"= ra"ius C > 1.! an?strom v"= ra"ius N > 1.9 an?strom v"= ra"ius O > 1.: an?strom v"= ra"ius 0 > 1.5 an?strom v"= ra"ius P > 2.1 an?strom v"= ra"ius S > 2 an?strom v"= ra"ius Cl > 1.9 an?strom v"= ra"ius @r > 2 an?strom v"= ra"ius I > 2.2 an?strom v"= ra"ius metals > 1.2 an?strom v"= ra"ius H > 1.2 an?strom v"= ra"ius O 4ater > 1.: an?strom v"= ra"ius all ot#er atoms > 1.! an?strom

ener?i > -4.451(2 k1alAmol

Lampiran D Data "atriks Anti HSV-1 Tabel IV.1 48

3ata matriks Anti HSV-1 Asiklovir

Bo?P HO<O BU<O )a-s Best ligan pose -Bo?BC58 mmolAB 3osis maksimal mmolAB 0amsiklovir

-1.29 -!.,85 8.814 !.,1! ener?i > -4.829!: k1alAmol 2.,9 8.999:

Bo?P HO<O BU<O )a-s Best ligan pose -Bo?BC58 mmolAB 3osis maksimal mmolAB

-8.(9 -!.8!9 -8.,!2 !.4! -ose 8 2itness > (.,!1!! k1alAmol 1.41 8.(224

41

)ansiklovir

Bo?P HO<O BU<O )a-s Best ligan pose -Bo?BC58 mmolAB 3osis maksimal mmolAB Pensiklovir

-1.92 -!.12, 8.84! !.1:2 ener?i > -4.,9!!: k1alAmol 2.92 8.:9,(

Bo?P HO<O BU<O )a-s Best ligan pose -Bo?BC58 mmolAB 3osis maksimal mmolAB

-1.( -!.,8: 8.88! !.,1( ener?i > -5.8!98: k1alAmol 1.5( 8.:9!:

42

Valasiklovir

Bo?P HO<O BU<O )a-s Best ligan pose -Bo?BC58mmolAB 3osis maksimal mmolAB 0oskarnet

8.41 -!.,8: 8.81( !.,2, ener?i > -,.58(11 k1alAmol 8.!! 8.(1((

Bo?P HO<O BU<O )a-s Best ligan pose -Bo?BC58mmolAB 3osis maksimal mmolAB

8.2( -12.1(( -8.:,2 12.9!9 ener?i > -4.451(2 k1alAmol 1.,8 8.(((4

4,