ONCOLOGY MCQ

1. Regarding G-CSF - the best description of its mechanism of action and roe in chemotherap! is
a. red"ced #MN nadir $hen "sed as proph!a%is
b. red"ced d"ration of ne"tropenia $hen "sed as proph!a%is
c. not "sef" "ness aread! ne"tropenic
d. red"ce thromboc!topenia se&erit!
e. red"ces mortait!
f. potentiates effects of chemotherap!
'. M"tations in $hich gene are east i(e! to be associated $ith breast cancer if inherited in the germ-ine)
a. *+M ,ata%ia-teangiectasia-
b. .RC*
c. .RC*'
d. .c-'
e. p/0
0. +he east i(e! to be associated $ith bo$e cancer is
a. *ta%ia teangiectasia
b. 1er-ab gene transocation
c. .RC*-1
d. .RC*-'
e. #c-'
2. 12 !ear od gir $ith 3odg(in4s disease is treated $ith radiotherap! ,mante fied-. 5hich is the most i(e!
secondar! carcinoma that co"d de&eop
a. breast
b. L"ng
c. th!roid
d. N3L
e. *ML
/. Yo"ng mae $ith germ ce cancer. 3e is on beom!cin. etoposide and cispatin"m.
5hat side effect $o"d ma(e !o" stop the treatment)
a. periphera ne"ropath!
b. ne"tropenic septicaemia
c. interstitia "ng disease
d. high tone hearing oss
6. Most i(e! ro"te of o&arian cancer spread7
a. peritonea
b. direct spread to adne%ae
c. !mphatic
d. direct spread to other organs
8. Man $ith med"ar! carcinoma of th!roid9 $orried abo"t his son. 5hat do !o" do)
a. !ear! cacitonin
b. oo( for ret oncogene in the cancer
c. oo( for ret oncogene in bood
d. pentagastrin stim"ation test
e. reass"re
:. Metastatic rena ce carcinoma9 s!mptomatic7
a. best s"pporti&e care
b. radiotherap!
c. s"rger!
d. interferon
e. ;inbastine
<. *n oder $oman $ith C* breast $ith bon! mets $ho $as on aminog"tamethonine. #ict"re of rash $hich
co&ered right breast and co&ered eft breast a itte9 sma nod"es9 some dead s(in and a fe$ sca! bits. Most i(e!
ca"se of rash)
a. f"nga
b. radiation
c. aminog"tamethonine reaction
d. s(in rec"rrence
e. =oster
1>. Mae $ith bone pain from metastatic prostate ca $i be started on L3R3 antagonist. 3e ref"ses
orchidectom!. 3is iness $i sho$7
a. immediate impro&ement
b. initia! $orse then impro&ement
c. immediate impro&ement then decine
d. so$ impro&ement
e. no change
11. 5hich of the foo$ing proto-oncogenes is east i(e! to be associated $ith an increased ris( of breast cancer)
a. *+M ,ata%ia teangiectasia-
b. .RC*-1
c. .RC*?'
d. .c '
e. p/0
f. 3@R-'ne"
g. 5is(ott *drich S!ndrome
1'. * 2>-!ear-od mae is operated on for a med"ar! carcinoma of the th!roid. 3e e%presses concern abo"t his
1> !o son getting the disease. +he best test7
a. b. Year! cacitonin in son
b. !ear! pentagastrin-stim"ated cacitonin in son
c. 1N* ana!sis for R@+ proto-oncogene in t"mo"r
d. 1N* ana!sis for R@+ proto-oncogene in periphera bood
e. +h!roid "traso"nd in son
10. #atient $ith germ ce t"mo"r recei&ing .@#. 5hich side-effect $o"d necessitate cessation of the responsibe
dr"g7
a. ne"tropenia
b. high-tone se&ere hearing oss
c. periphera ne"ropath!
d. interstitia "ng damage
12. Cispatin ind"ced ne"ropath! $i ha&e $hich of the foo$ing feat"res on ner&e cond"ction st"dies7
a. ;ariet! of descriptions $ith incAdec &eocities9 absence F $a&es9 sensor! &s motor9
b. One mentioned 3 $a&e9 increased or decreased ampit"de9 etc.
1/. * femae presents $ith shortness of breath. CBR is sho$n $ith $hiteo"t of L "ng. +od ne"rone-specific
enoase C&e9 ne%t best step in management7
a. .ronchoscop! $ith aser
b. Radiotherap!
c. Chemotherap!
d. .est s"pporti&e care
e. S"rgica resection
16. 5hich of the foo$ing best describes the incidence of coon cancer $ith age7
a. Linear increase $ith age
b. Linear increase $ith patea" after age />
c. #araboic
d. @%ponentia rise after age />
e. .imoda distrib"tion $ith pea(s at age /> and 8>
18. * of the foo$ing can occ"r in germ ine eading to breast cancer e%cept $hich one7
a. .RC*1
b. .RC*'
c. .c-'
d. p/0
e. *ta%ia teangiectasia gene
1:. 5hich of the foo$ing is the east i(e! to be in&o&ed in hereditar! coon cancer7
a. *#C gene
b. 1N* repair gene
c. Microsateites
d. 1eetion of a gene
e. Chromosoma transocation
1<. * /> !o patient presents $ith metastatic rena ce carcinoma. +he best management $o"d be7
a. DFN-
b. DL-'
c. ;inbastine
d. .est s"pporti&e care
e. #rogesterone
'>. +he genetic defect in hereditar! non-po!posis coi ies in7
a. *#C gene
b. 1CC gene
c. 1N* repair defect
d. proto-oncogene
'1. * femae $ith a histor! of breast cancer remo&ed. #hoto sho$n ) pre&io"s modified radica mastectom! scar.
1iff"se er!thema9 $ith nod"es and paE"ing o&er and aro"nd scar $ith some e%tension onto contraatera breast is
e&ident. +he most i(e! diagnosis is7
a. Radiation reca
b. F"nga infection
c. +"mo"r rec"rrence
d. 3erpes =oster
''. 5hich is the strongest predictor of an increased ris( of breast cancer in a 2> !o $oman7
a. @ar! menarche
b. Late first pregnanc! F 0> !o
c. #re&io"s breast carcinoma in contraatera breast
d. Mother $ith breast cancer at age 8>
e. 3ormone repacement therap!
'0. * !o"ng mae has non-3odg(in4s !mphoma. +he LMO starts prednisone $hist a$aiting a haematoog!
admission. 3e presents "n$e $ith 5CC pre&io"s! 0>9 no$ '9 "rate '.09 G :.>9 phosphate 1>9 Cr .'/. +he most
i(e! diagnosis)
a. Hrate nephropath!
b. +"mo"r !sis s!ndrome
c. 1eh!dration
d. L!mphoma infitration of (idne!s
'2. * !o"ng femae ,0> !o- had mante radiotherap! in her teens. +he most i(e! cancer site in her no$7
a. +h!roid
b. .reast
c. .one marro$
d. L"ng
e. L!mph nodes
'/. +he most common mechanism of spread of epitheia o&arian cancer is7
a. 3aematogeno"s
b. L!mphatics
c. *dIacent str"ct"res
d. +rans-coeomic
'6. * man $ith metastatic prostate cancer $ith increasing bone pain. +he decision is made to start a GnR3
agonist Yo"r ad&ice regarding the i(e! effect of this7
a. Dmmediate reso"tion of s!mptoms
b. Dnitia $orsening of s!mptoms o&er t$o $ee(s foo$ed b! grad"a reso"tion
c. 1ea!ed reso"tion of s!mptoms
d. So$ progressi&e impro&ement of s!mptoms
e. Dnitia reso"tion foo$ed b! se&ere $orsening of s!mptoms
'8. Concerning "ng cancer7
a. Dn *"straia9 the incidence in $omen is faing.
b. +he "se of chemotherap! in combination $ith radiotherap! in patients $ith stage DDD non-sma ce "ng cancer
is associated $ith impro&ed s"r&i&a.
c. Chemotherap! for metastatic non-sma ce "ng cancer impro&es E"ait! of ife b"t not s"r&i&a.
d. +he optima treatment for imited stage sma ce "ng cancer is $ith chemotherap! aone.
e. #araneopastic manifestations occ"r in the maIorit! of patients.
':. Regarding famiia breast cancer9 $hich of the foo$ing statements is tr"e)
a. the maIorit! of cases are aso associated $ith m"tations of the p/0 gene.
b. m"tation of the .RC*1 gene ma! be associated $ith an increased ris( of both breast and o&arian cancer.
c. chemopre&ention $ith tamo%ifen is of pro&en benefit.
d. most affected famiies share the same specific m"tation of the .RC*1 gene.
e. abo"t 8/J of affected fami! members de&eop breast cancer before the age of 0/ !ears
'<. .RC*-17
a. +!pe of oncogene
b. *ssociated $ith mae breast cancer
c. *ssociated $ith breast and o&arian cancer
d. *ssociated $ith sporadic breast cancer
e. #rod"ces a tr"ncated protein
0>. Oesophagea cancer is associated $ith7
a. *coho ab"se
b. Corrosi&e-associated damage
c. *chaasia
d. Ref"%
e. Smo(ing
01. Concerning d!spastic nae&i7
a. Hs"a! K / mm in diameter
b. 3omogeneo"s! tan or bac(
c. Df positi&e fami! 3% of maignant meanoma9 and indi&id"a has d!spastic nae&"s9 F />J chance of
meanoma in ifetime
0'. Sma ce "ng cancer is ) more associated $ith ,) than NSCLC-
a. caci"m
b. C"bbing
c. C"shingLs
d. @aton-Lambert s!ndrome
e. 3!ponatraemia
00. Regarding ce (inetics of cancer7
a. 1 cm t"mo"r M 1>< ces
b. Ces in G> are high! sensiti&e to chemotherap!
c. Common cancers ha&e do"bing times of '> da!s
d. Dntrinsic m"tation rate in common cancers ? 1 in 1>6 ces
e. Gro$th in primar! cancer decreases in the ater stages of de&eopment
02. 80 !o femae $ith metastatic breast cancer9 on tamo%ifen for 6A1'. 'A8 3% of na"sea and thirst. Na
C
1//9 G
C

/.'9 "rine osm 108. 3as m"tipe mets inc"ding sea t"rcica. Ne%t most appropriate mgt7
a. Saine
b. F"id restriction
c. Dntranasa desmopressin
d. *#1
e. 1emecoc!cine
0/. #re-menopa"sa $oman fo"nd to ha&e eft a%iar! and s"praca&ic"ar nodes. .% sho$ed poor!
differentiated cancer9 oestrogen receptor poor. She has no other S%9 e%amination is other$ise norma and CBR and
mammogram are norma. Ne%t D%7
a. @ndoscop!
b. .ronchoscop!
c. Loca BR+
d. Chemo and BR+
e. 3ormona R%
06. * patient $ith (no$n disseminated !mphoma is anaemic9 $ith 3b M 1>>9 MC; M 829 Fe M 29 Ferritin M 0>>.
+his is best e%pained b!7
a. Fe deficienc!
b. impaired reease of Fe from macrophages
c. red"ced er!thropoietin
d. retic"oc!tosis
e. increased pasma cearance of Fe
08. Radiotherap! has its most se&ere effects on $hich tiss"es)
a. i&er
b. (idne!
c. "ng
d. bone marro$
e. spina cord
0:. 5hich of the foo$ing is east i(e! to res"t form the administration of beom!cin)
a. sodi"m "rate
b. caci"m p!rophosphate
c. caci"m h!dro%!apatite
0<. #t $ith metastatic bo$e cancer is ta(ing Codeine 0> mg E2h $itho"t adeE"ate anagesia. 5hat is the most
appropriate therap!)
a. contin"e Codeine and add #aracetamo 1g Eid
b. stop Codeine9 start MS Contin > mg bd and #aracetamo 1g Eid
c. stop Codeine9 start MS Contin '> mg bd and #aracetamo 1g Eid
d. stop Codeine9 start MS Contin > mg bd and #anadeine ii Eid
2>. Concerning the proph!actic "se of G-CSF d"ring cancer chemotherap!7
a. it decreases the d"ration of ne"tropenia
b. it decreases the se&erit! of the ne"tropenic nadir
c. it increases pateet n"mbers
d. it potentiates the effect of chemotherap!
e. it is on! "sef" in estabished ne"tropenia
21. Regarding this condition ,photo of m"tipe d!spastic nae&i-. 5hich of the foo$ing statements are
incorrect)
a. Some esions ha&e the cinica feat"res of a meanoma
b. Dndi&id"as $ith this condition ha&e an increased ris( of meanoma $hen compared $ith the genera
pop"ation
c. +he ris( of meanoma is ess in sporadic than famiia forms
d. @pi"minescent microscop! has not been sho$n to aid earier cinica detection of meanoma
e. Reg"ar photograph! ma! be of &a"e as meanomas a$a!s arise $ithin e%isting esions