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Muscle cells are “excitable cells”. Like neurons, action potentials can
be produced in response to chemical, electrical, or mechanical stimuli. Due
to the presence of contractile elements, muscle response is able to generate a
force, which could be used in the performance of many activities, for
example, movement of the body parts, mixing of foods, elimination of
wastes, etc.
A. Types of muscles:
1. Skeletal muscle
- cross striations are a very prominent feature
- muscle fibers are distinctly separate
- normal contractions is in response to nervous
stimulation
- under voluntary control
2. Cardiac muscle
- is also striated
- functionally responding as a single muscle fiber
- contracts automatically and rhythmically even in the
absence of its nerve supply
- involuntary
3. Smooth muscle
- unstriated
- may posses some automaticity and rhythmicity
- involuntary
B. Muscle contraction:
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1. Electrical changes: Excitation of the skeletal muscle fiber.
2. Mechanical changes
Depolarization of the muscle fibers results in contraction.
The transformation of electrical to mechanical activity involves
chemical reactions and the process is called excitation-
contraction coupling.
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Stages:
(i) Latent period
The interval between the depolarization of the
muscle fiber and the beginning of muscle
contraction.
. The duration of the muscle twitch varies, depending on the specie and
the type of muscle. It maybe as short as 7.5 msec. in “fast” muscle such as
those concerned with fine, rapid and precise movements. It maybe as long as
100 msec. – 200 msec. in “slow” muscle like those concerned with
maintenance of posture.
Example:
Contraction of muscles maintaining posture and
equilibrium and when one holds on object.
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The muscle shortens under a constant load. Weight is
carried through a distance and thus work is performed
(positive work)
( c) Mechanism of shortening
( i) Molecular background
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sarcotubular system (T-tubules and sarcoplasmic
reticulum)
- Ca++ ions are released from the terminal cisterns
(lateral saca) of the sarcoplasmic reticulums and
diffuses to the reactive sites.
- Ca++ binds to troponin C
- Removal of inhibitory action of the troponin-
tropomyosin complex on action
- Interaction between actin and myosin; myosin heads
attach to actin reactive sites (formation of cross-
bridges)
- Breakdown of ATP and release of energy
- “Swiveling” or “rowing” movement of myosin heads
attached to actin. After each rowing movement the
myosin head detaches from the actin, swings back and
binds with the next actin reactive site.
- Repeated attachment, swiveling and detachment of the
myosin cause the sliding of the thick and thin filaments
along and past each other thus causing shortening. This
mechanism is the so-caled sliding filament theory of
muscles contraction.
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muscles of the hand and eye, where the muscle fibers on the
motor unit maybe as low as 3-6. Muscles concerned with coarser
movements like those for maintainance of posture have more
fibers in the motor unit, averaging 180 fibers.
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4. Thermal changes
The liberation of energy during muscle contraction is associated
with the production of heat.
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A single maximal stimulus will cause the development maximal
tension. If another stimulus, stronger than maximal, is applied, the twitch
tension developed will still be of the same magnitude.
But if two maximal stimuli are used successively with the second
being applied while the muscle is still responding to the first stimulus,
response greater than that produced by a single maximal stimulus, will be
elicited. Several stimuli applied successively in this manner cause responses
of increasing magnitude. The phenomenon is called wave summation. If
the stimuli will applied at t a rapid rate, all contractile elements are
maximally stimulated, all elastic component are stretched fully and a
sustained contraction is produced. This is called tetanus. If the rate of the
stimulation is slower, mechanical fusion may not occur. The individual
contractions maybe discernible and the phenomenon is called incomplete
tetanus. The rate of stimulation capable the producing tetanus varies.
Examples:
350 stimuli/sec. for internal rectus
30 stimuli/sec. for sole us muscle
E. Length-Tension Relationship
Muscle is made up of contractile elements and elastic tissues. If no
stretch is initially applied on the muscle, the active tension produced by
muscle contraction will be less since the pull merely stretches the elastic
tissue (series-elastic components). If the muscle will be stretched passively
and passive tension develops, the active tension produced by muscle
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contraction, increases. The greater passive tension, the greater is the tension
produced up to a certain point. Beyond which, any further passive
stretching of the muscle reduce the active tension developed during
contraction. The length of the muscle in which maximum active tension is
developed when the muscle is stimulated is called the resting length. This is
the normal length of the muscle in the body. At thus length, the muscle is
lightly stretched and therefore, there is some degree of passive tension
present. Proof of this, is the shortening of a muscle that occurs when the
tendon is severed from its attachment.
G. Smooth Muscle:
1. Types:
(a) Multi-unit smooth muscle
(i) Characteristics:
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- Stretching to a new length initially increases tension but
this tension diminishes as the new length is attained.
This property of “elasticity” allows an increase in the
volume of the organ without a very great rise in
pressure.
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