INSUHALER- An IMPROVED INSULIN INHALER – painless insulin puff

PROBLEM: Exubra a millions $ failure was due to 10 inch long device, needed
compressed air for spray, 10% efficient, poor inhalation effort -despite large insulin
users. There is no compact, deep inhaling, germ free inhalers till date. Our 3 inch device
with no compressed gases, better lung deposit, and no pain insulin may be a great relief
for majority insulin using diabetics. We solved better easy inhalation with a tiny, portable
any where use inhaler just right for stable insulin powder (better than liquid insulin?).

PROBLEMS OF HUMAN INHALATION Humans have a complex anatomy & physiology of

inhalation. We inhale 500cc in adults- this volume must be used to form a spray with effort of
inhalation and send to air sacs for blood transfer. Existing inhaler design & working is focused
on powder spray by complicated angles or vibrators, or electrical discharges and not correct
inhalation. What ever spray produced, if not properly inhaled will deposit in mouth only- leading
to failed low lung deposit, as in all devices. Diabetes is increasing & affects all ages, more kids
too. Ideal inhaler must release a drug spray with low coating in the mouth. Spray must be of low
velocity with longer duration of spray for easy inhalation into lungs.

EXISTING POWDER DEVICES: Discuss, rotahaler, Exubra with inhaling figures

All short mouth

piece shallow breathers. Defects in the existing inhaler devices are as follows:

1. Fast inhalation, - allowing short time for inhalation!

2. Wider drug spray- coating the spray into mouth.
3. The larger, wider mouthpiece produces shallow inhalation and allows
little time and effective suction for drug deposition in the lungs. Mouth coating is
due to combination of above factors.
4. Dusty, polluted air is inhaled without a filter that may cause disease to users
OUR INHALER: The inhaler comprises of an easy holding hollow plastic body with a front
narrow longer mouth piece. The needed powder from multi dose blister strip pierced or capsules
deposit the dry powder in a drug chamber in the body. This chamber has a small hole to drop
the powder (white) by pressing a sliding knob (black) in the fast spray zone. The outside air is
pulled through a back dust filter in the body for clean air inhalation. The air channel 20 mm wide
@ the back narrows to 6mm mouthpiece, creating a fast air jet that sprays the drug as a mist
through mouthpiece. The longer mouth piece leads straight to back of throat for lung deposit.

Just 3 inches! 1CM longer vs. Rotahaler- handy

Mouth piece in Rotahaler 2cm wide, ours 8mm –easy inhalation, for kids too!

Back (black) filter that traps dust! Back Aperture

20mm narrows to 6mm inner air channel creates fast air jet that forms a good drug spray.

Working: Load powder from capsules/ blister. Keep in mouth inhale. Press knob (black)
when inhaling. Powder drops, forms a spray traveling to lungs. Wide body narrowing makes
a faster, optimum jet than all inhalers that sprays the powder. An inside baffle declumps
powder too for smooth spray. Kids 4-6 years can inspire 200 ml that can form a spray in ours.

TESTS DONE 1. Length of inhalation –longer in ours- more time to send drug to lungs
2.Easy Hold in mouth for kids too -as small 8mm not 2cms 3 Mouth coating: ADDED dye
apple green to the powder, inhaled both. Ours- no staining, but others- fully coated showing
deep inhalation lower mouth deposit in ours 4 User friendliness in holding, portability,
inhalation, use: better in ours 5 Depth of inhalation: do you feel lungs filling? Ours yes,
 others- not much. Just inhale in an 8mm vs. 15mm diameter 2 inch long plastic tube! Feel
the difference!

2. PERFORMANCE EVALUATION OF THE PRODUCT

Character DPI/EXUBRA Ours

inspiration 4 seconds 7-8 seconds
Depth of inhalation moderate Real deep
Feel of drug flow In mouth Into lungs
relief partial more
Size- Length ,width bigger Compact for performance
portability Bigger size Ok, better
holding clumsy Easy to hold, than exubra
Spray Dye test Wider, mouth coating Lower mouth coating
Powder fall with tilt yes no
Velocity of air @inhaler lower Higher, you can feel it as smooth
mouthpiece flow
Drug mist flow Against gravity(below> up) Aided by gravity (up>down!)
c. PROS AND CONS of the product with respect to existing technology. This is a
demonstration of better inhaler. We added green dye to powder& inhaled. Ours- more lung

deposit, low mouth coating. This is ours gree ex

mouth deposit with otherDPI showing larger moth coating. May be good for kids, adults,
illiterates too.
Advantages of the new invention:
1. Long, Slow and deep inhalation, as air is drawn through a smaller
air hole.
2. The device has more time to inhale -the inhalation is 6 seconds vs.
2-3.
3. There is lower mouth coating and less waste of drug spray.
4. Useful for kids, old, illiterates- who can now inhale the spray easily.
5. The filter removes all air polluting dust and germ particles for safe
inhalation.
6. Compact, no gases, simple device.
Insulin puff after meals may be possible now- this can deliver for kids too! Lungs are
good insulin absorbers.
Help for clinical trials from insulin makers solves-invented 2010.Design, patent filed.
VIJAYAN: vijayanrd@rediffmail.com