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Rodenticides are defined as any substance that is used to kill rats, mice, and
other rodent pests. Almost rodenticides are synthetic, but there is also non-toxic natural
rodenticides such as cellulosa. This consists only of natural cellulose derived from
maize. It works by interfering with the rodent’s water absorption, thus causing
dehydration. Due to the unique way in which rodent’s stomachs process food, it is
completely safe for other mammals and birds.
Classification of Rodenticides
No Class Example Note
1 botanical rodenticides Scilliroside, Strychnine Strychnine is a natural toxin
which causes violent convulsion
by direct excitatory action on the
cells of the central nervous
system chiefly the spiral cord
2 carbanilate rodenticides 3-pyridylmethyl 4- Destroy the pancreatic beta cell
nitrocarbanilate (mieshuan)
3 coumarin rodenticides First generation : warfarin, These substances kill by
coumachlor,coumafuryl, preventing normal blood clotting
coumatetralyl,dicoumarol and causing internal
Second generation :
hemorrhaging.
brodifacoum, bromadiolone,
difenacoum,difethialone
flocoumafen
4 indandione rodenticides Chlorophacinone,diphacinone These are harder to group by
generation. According to some
pindone ,valone sources, the indandiones are
considered second generation
5 inorganic rodenticides arsenous oxide, phosphorus All these poisons are toxic to
potassium arsenite other animals, and most cause
sodium arsenite death by disturbance of nervous-
thallium sulfate system functions.
zinc phosphide
6 organochlorine gamma-HCH, HCH, lindane -
rodenticides
7 organofluorine Fluoroacetamide, sodium -
rodenticides fluoroacetate
8 organophosphorus Phosacetim -
rodenticides
9 pyrimidinamine Crimidine Cirimide is a syntgetic
rodenticides chlorinated pyrimidine
(Convulsant) compound that in adequate
dosage cause violent convulsion
similar those produce by
strychine.
10 thiourea rodenticides Promurit, thiosemicarbazide -
11 urea rodenticides Pyrinuron -
12 Miscellaneous Red squill, cholecalciferol red squill containing a cardiac
rodenticides glycoside as an active ingredient,
red squill is intensely nauseant.
13 unclassified Bromethalin, chloralose Uncouple oxidative
rodenticides α-chlorohydrin, curcumenol phosphorylation (bromethalin)
ergocalciferol, flupropadine Lead to vasoconstriction with
hydrogen cyanide,norbormide ischemia (norbormide)
silatrane, tetramine
There are wide variety of materials are used as rodenticides. They pose a particular
risk for accidental poisonings for several reasons:
1. First, as agents designed to specifically kill mammals, often their toxicity is very
similar for the target rodents and for humans. (Warfarin and other anticoagulant
rodenticides were initially developed to overcome this problem by creating
compounds that wee highly toxic to rodents, particularly after repeated
exposures, but much less toxic to humans).
2. Secondly, since rodents share the same environment as humans and other
mammals, the risk of accidental exposure is an integral part of the placement of
baits for the rodents.
3. Thirdly, as rodents have developed resistance to Warfarin and others, there is a
continuous need to develop new and potentially more toxic rodenticides. Thus
we end up with 2nd and 3rd generation rodenticides which have increased the
risk to humans.
1. RAMIX PRODUCT
A. RAMIX GREEN BAIT PACK
PRODUCT IDENTIFICATION
- Product Name: Ramik® Green Bait Pack Kills Rats and Mice Fish Flavored
Weather-Resistant Rodenticide for Control of Norway Rats, Roof Rats and
House Mice
- EPA Signal Word: CAUTION
- Active Ingredient (%): Diphacinone (0.005%) CAS No.: 82-66-6
- Chemical Name: 2-Diphenylacetyl-1,3-Indandione
- Chemical Class: An indandione-type anticoagulant rodenticide.
- EPA Registration Number: 61282-48
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
Diphacinone (2-Diphenylacetyl-1,3-Indandione) ............................. 0.005%
INERT INGREDIENTS:................... ........................................... 99.995%
TOTAL: ............................................................................... 100.000%
TOXICOLOGICAL INFORMATION
- Acute Toxicity/Irritation Studies (Finished Product)
- Ingestion: Low Toxicity
- Oral (LD50 Rat) : > 7 mg/kg body weight (Diphacinone Technical at 98%
active)
- Oral (LD50 Rat) : > 100,000 mg/kg body weight (Ramik Green Bait Pack)
B. RAMIX BARS
PRODUCT IDENTIFICATION
- Product Name: Ramik® Bars All-Weather Rat and Mouse Killer
- EPA Signal Word: CAUTION
- Active Ingredient (%): Diphacinone (0.005%) CAS No.: 82-66-6
- Chemical Name: 2-Diphenylacetyl-1,3-Indandione
- Chemical Class: An indandione-type anticoagulant rodenticide
- EPA Registration Number: 61282-12
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
TOXICOLOGICAL INFORMATION
Oral (LD50 Rat) : > 7 mg/kg body weight (Diphacinone Technical at 98% active)
Oral (LD50 Rat) : > 100,000 mg/kg body weight (Ramik Bars)
2. HAVOC PRODUCT
A. HAVOC XT-BLOCK
PRODUCT IDENTIFICATION
- Product Name: HAVOC® XT BLOK KILLS RATS & MICE
- EPA Signal Word: CAUTION
- Active Ingredient (%): Brodifacoum Technical (0.005%) CAS No.:
56073-10-0
- Chemical Name: 3-[3-(4’-bromo[1,1’-biphenyl]-4-yl)-1,2,3,4-tetrahydro-
1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one
- Chemical Class: A coumarin-type anticoagulant rodenticide.
- EPA Registration Number: 100-1055-61282
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
Brodifacoum -3-[3-(4’-bromo-[1,1’-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-
naphthalenyl]-4- hydroxy-2H-1-benzopyran-2-one..................................0.005%
OTHER INGREDIENTS :...................................................................99.995%
TOTAL ................................................................................................100.000%
Contains Bitrex® brand denatonium benzoate
TOXICOLOGICAL INFORMATION
- Acute Toxicity/Irritation Studies (Finished Product)
- Ingestion: Practically Non-Toxic
- Oral (LD50 Rat) : > 5,000 mg/kg body weight
PRODUCT IDENTIFICATION
- Product Name: HAVOC® RODENTICIDE BAIT PACK (PELLETS)
KILLS RATS & MICE
- EPA Signal Word: CAUTION
- Active Ingredient (%): Brodifacoum Technical (0.005%) CAS No.:56073100
- Chemical Name: 3-[3-(4’-bromo[1,1’-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-
naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one
- Chemical Class: A coumarin-type anticoagulant rodenticide.
- EPA Registration Number: 100-1056-61282
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
Brodifacoum - 3-[3-(4’-bromo-[1,1’-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-
naphthalenyl]-4- hydroxy-2H-1-benzopyran-2-one..................................0.005%
OTHER INGREDIENTS :................................................................99.995%
TOTAL .........................................................................................100.000%
Contains Bitrex® brand denatonium benzoate
TOXICOLOGICAL INFORMATION
Acute Toxicity/Irritation Studies (Finished Product)
Ingestion: Practically Non-Toxic
Oral (LD50 Rat) : > 5,000 mg/kg body weight
Dermal: Slightly Toxic
Dermal (LD50 Rat) : > 2,000 mg/kg body weight (calculated from technical material)
C. HARVOV CHUNK
PRODUCT IDENTIFICATION
- Product Name: HAVOC® CHUNKS KILLS RATS & MICE
- EPA Signal Word: CAUTION
- Active Ingredient (%): Brodifacoum Technical (0.005%) CAS No.:
56073-10-0
- Chemical Name: 3-[3-(4’-bromo[1,1’-biphenyl]-4-yl)-1,2,3,4-tetrahydro-
1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one
- Chemical Class: A coumarin-type anticoagulant rodenticide.
- EPA Registration Number: 61282-27
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
Brodifacoum - 3-[3-(4’-bromo-[1,1’-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-
naphthalenyl]-4-hydroxy-2H-1- benzopyran-2-one ..................................... 0.005%
INERT INGREDIENTS: ............................................................. 99.995%
TOTAL .................................................................................... 100.000%
TOXICOLOGICAL INFORMATION
Acute Toxicity/Irritation Studies (Finished Product)
Ingestion: Practically Non-Toxic
Oral (LD50 Rat) : > 5,000 mg/kg body weight
Dermal: Slightly Toxic
Dermal (LD50 Rat) : > 2,000 mg/kg body weight (calculated from technical
material)
3. CYKILL PRODUCT
PRODUCT IDENTIFICATION
- Product Name: CyKill™ Place Packs Kills Rats and Mice Breaks the
Cycle
- EPA Signal Word: CAUTION
- Active Ingredient (%): Bromethalin (0.01%) CAS No.: 63333-35-7
- Chemical Name: [N-Methyl-2, 4-dinitro-N-(2,4,6-tribromophenyl)-6-
(trifluoromethyl) benzenamine]
- Chemical Class: An acute rodenticide
- EPA Registration Number: 47629-13-61282
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
Bromethalin: .................................................................... 0.01%
OTHER INGREDIENTS: ........................................... 99.99%
Total ...................................................................... 100.00%
TOXICOLOGICAL INFORMATION
- Ingestion: Acute Toxicity
- Oral (LD50 Rat) : 9.1 mg/kg (Bromethalin Technical)
- Dermal: Acute Dermal Effects
- Dermal (LD50 Rabbit) : 2000 mg/kg (Bromethalin Technical)
- Inhalation: Acute Inhalation Effects
- Inhalation (LC50 Rat, 1 hr.) : 0.024mg/L (Bromethalin Technical)
- Eye Contact: Mild, transient irritation.
Skin Contact: Non-irritating.
4. DI KILL PRODUCT
A. DI KILL PLACE PACK
PRODUCT IDENTIFICATION
- Product Name: Di-Kill™ Place Packs Kills Rats and Mice
- EPA Signal Word: CAUTION
- Active Ingredient (%): Difenacoum (0.005%) CAS No.: 56073-07-05
- Chemical Name: [3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-napthyl)-4-
hydroxycoumarin]
- Chemical Class: A coumarin-type anticoagulant rodenticide.
- EPA Registration Number: 47629-17-61282
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
Difenacoum....................................................................0.005%
OTHER INGREDIENTS:.........................................99.995%
Total ....................................................................100.000%
TOXICOLOGICAL INFORMATION
- Acute Toxicity/Irritation Studies (Technical Product)
- Ingestion: Acute Toxicity
- Oral (LD50 Rat) : 1.8-2 mg/kg (Difenacoum Technical)
- Dermal: Acute Dermal Effects
- Dermal (LD50 Rabbit) : >50 mg/kg (Difenacoum Technical)
- Eye Contact: Mild, transient irritation.
- Skin Contact: Non-irritating.
5. PROZAP PRODUCT
A. PROZAP PELLET
PRODUCT IDENTIFICATION
- Product Name: Prozap® Zinc Phosphide Rodent Pellets
- EPA Signal Word: CAUTION
- Active Ingredient (%): Zinc Phosphide (2.00%) CAS No.: 1314-84-7
- Chemical Name: trizinc diphosphide
- Chemical Class: An inorganic compound.
- EPA Registration Number: 61282-50 Section(s) Revised: 7
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
Zinc Phosphide ..................................................................2.0%
INERT INGREDIENTS: ............................................... 98.0%
Total ..................................................................... 100.0%
TOXICOLOGICAL INFORMATION
- Acute Toxicity/Irritation Studies (Finished Product)
- Ingestion: Ingestion Hazard
- Oral (LD50 Rat) : 910 mg/kg body weight (2.00% pelleted bait)
- Dermal: Toxic
- Dermal (LD50 Rabbit) : > 2,000 mg/kg body weight (2.00% pelleted bait)
PRODUCT IDENTIFICATION
- Product Name: Prozap® Mole and Gopher Pelleted Bait
- EPA Signal Word: CAUTION
- Active Ingredient (%): Zinc Phosphide (2.00%) CAS No.: 1314-84-7
- Chemical Name: trizinc diphosphaide
- Chemical Class: An inorganic compound.
- EPA Registration Number: 61282-50 Section(s) Revised: 7
COMPOSITION/INFORMATION ON INGREDIENTS
ACTIVE INGREDIENT:
Zinc Phosphide..................................................................2.0%
INERT INGREDIENTS:...............................................98.0%
Total...............................................................................100.0%
TOXICOLOGICAL INFORMATION
- Acute Toxicity/Irritation Studies (Finished Product)
- Ingestion: Ingestion Hazard
- Oral (LD50 Rat) : 910 mg/kg body weight (2.00% pelleted bait)
- Dermal: Toxic
- Dermal (LD50 Rabbit) : > 2,000 mg/kg body weight (2.00% pelleted bait)
MOLLUSCICIDES
Molluscicides, also known as snail baits and snail pellets, are pesticides against
molluscs, which are usually used in agriculture or gardening to control gastropod pests
like slugs and snails that can damage crops by feeding on them.
1. Natural molluscides
a. Aglaia elaeagnoidea
extract of dichlormetane in leaf has antimicroba activities to Bacillus
subtilis dan as molluscicides.
2. Synthetic molluscicides
2. Post-emergence Herbicide
Given after the first seed leaf display. Herbicides of this type should be selective, in the
sense of not disturbing the plant anyway.
1. Glufosinate-ammonium
Work herbicide glufosinate-ammonium in fact, based on the deactivation of the enzyme
glutamine synthesis. Glutamine synthesis causes a reaction of ammonia and glutamic
acid to form glutamine. Ammonia, a substance that is very phytotoxic to plant cells
formed at the time of plant biochemical processes, precisely when the reduction of
nitrate, amino acid metabolism and photo-respiration. Given the fact that this enzyme is
disabled by glufosinate, ammonia can accumulate in plant cells and causes necrosis of
the lining of the plant which ultimately caused the death of the plant. Speed of action
depends on external conditions, such as humidity, temperature and moisture content in
soil. Intake of glufosinate-ammonium by plants is usually carried out through the green
leaves and plants are growing actively.
2. Glyphosate
Herbicide active ingredient glyphosate is a systemic herbicide for weed targets. Among
the four types of the active ingredient, glyphosate is the herbicide active ingredient most
widely used around the world. In addition to the systemic nature which kills the plant to
die down to the roots, are also able to control many types of weeds such as Imperata
cylindrica, Eulisine indinca, Axomophus comprsseus (pahitan), Mimosa invisa
(daughter of shame), Cyperus Iria (puzzle), Echinocloa crussgali (jajagoan ) and
others. Examples of glyphosate herbicide on the market like Rambo 480AS, 240 U.S.
Ranger, and others. The recommended applications of glyphosate herbicide was 100
ml / 14 L water for Rambo 480AS, and 150 ml ml/14 liters. glyphosate, the herbicide
most important in today's world, is herbicide translocation, inhibiting the action of the
enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), an enzyme involved in
the synthesis of three amino acids. Lim et al. (1999) reported that the use of glyphosate
caused the succession of weeds into broadleaf weed dominance. Faiz (1989) reported
that spraying of glyphosate mixture successively in rubber adult (TM) for general weed
control causes the dominance Borreria alata, senduduk (Melastoma malabathricum), and
reed (Imperata cylindrica). Succession-related weeds closely with how the herbicide is
working (modes of action). Glyphosate translocation from the leaves down to the roots
and other parts of the overall system damage in the body of weeds. Glyphosate has a
high killing power of grass and often eradicate the weed grasses such as Paspalum
conjugatum software and Ottochloa nodosa and eventually ground into the
open. Opportunities like this provide an opportunity for many of the seeds of broadleaf
weeds to germinate and eventually become dominant (Tjitrosoedirjo and Purba,
2006). Dominance of broadleaf weeds often tend to be more detrimental because it is
more difficult to control. Weeds software such as O. nodosa, P. conjugatum and
A. compressus needs to be preserved in oil palm planting (Teoh, 1984). Grass weeds
such as these are categorized as class B which is useful and requires less control B
(Anon, 1972). The use of glyphosate on an ongoing basis often leads to the occurrence
of weed eradication software while the reverse shows a mixture of paraquat (Khairul &
Teoh, 1992).
3. Paraquat
This herbicide is a contact herbicide commonly used to full grown. Which contain
active herbicide Paraquat is highly suitable for use by those who wish to cultivate land
for quick and immediate. This is because the power of paraquat is so fast that after
application, the result can be seen an hour later, so that within 3-4 days arable land
next. The examples that contain active herbicide paraquat in Indonesia just two of
Noxone 276AS and Gramoxone. Paraquat is a contact herbicide which kill plants by
disrupting cell membranes. According to Chung (1995) the use of paraquat has
advantages in terms of succession of weeds, fitotoksisitas, and rainfastness. Paraquat,
herbicide contact, causing death at the top of the weeds quickly without damaging the
root system, stolon, or rods in the ground, so that within a few weeks after the
application of weeds grow back.
4. Metsulfuron Methyl
Which contain active herbicide metsulfuron methyl is a systemic herbicide and is
selective for the rice plant. Herbicides can be used to control weeds and early pre-grown
full grown. Some weeds that are controlled by herbicides mapu include: Monocholria
vaginalis (water hyacinth), Cyperus diformis (puzzle), Echinocloa crusgalli (jajagoan),
clover and other weeds that are categorized as ferns. Billy 20WP is one such
example. Applications suggested recommendations for the use of this herbicide is 2.5
grams for each tank of 14 liters.
5. 2,4 – D
2,4 - D including one herbicide active ingredient best known. The nature of this
herbicide more or less similar to metsulfuron methyl are systemic and
selective. Herbicides can be used to control weeds either full grown broadleaf and
puzzles in rice paddies. As for some types of weeds that can be controlled with the
herbicide 2,4-D is between: Monochoria vaginalis (hyacinth), Spenochlea zeylanica,
Cyperus Iria (puzzle), Limnocharis flava (velvetleaf), water spinach, taro and
others. Examples of herbicides 2,4-D is Amandy 865AS.