Hypersensitivity

Arfiani Dwi Ika Endra Kusumawati

Kusumaningtyas
 Altered reactivity to an antigen,
which can result in pathologic
Definition (MSH) reactions upon subsequent exposure
to that particular antigen.

state of previously immunized body

in which tissue damage results from
Definition (CSP)
the immune response to a further
dose of antigen.

Hypersensitivity to an agent caused

Definition (HL7V3.0) by an immunologic response to an
initial exposure
 Hypersensitivity; a local or general
reaction of an organism following
contact with a specific allergen to
Definition (NCI)
which it has been previously
exposed and to which it has
become sensitized.
An exaggerated response by the
Definition (NCI) immune system to a drug or other
substance.
An inflammatory response to an
exogenous environmental antigen
or an endogenous antigen initiated
Definition (GO)
by the adaptive immune system.
[GOC:jal, ISBN:0781735149
"Fundamental Immunology"]
Hipersensitivitas ????

Gambar : Sistem imunitas yang non spesifik

dan yang spesifik
 Classification

Type I Type II

Type III Type IV

Type I anaphylactic hypersensitivity
HYPERSENSITIVITY TYPE I
Type II ADCC/CDC
Type II ADCC/CDC
 Type II ADCC/CDC
Antibody-dependent cell-mediated cytotoxicity ADCC

Complement Natural killer cell Macrophage

pathway

Monoclonal
antibody
Fc
receptor
Cell
surface
antigen

Lymphoma cell
Type III immunecomplex
HIPERSENSITIVITAS SISTEM IMUN HUMORAL DAN SELULER
Tipe Ig/Ly Patogenesis Penyakit Hipersensitivitas
I Ig E IgE terikat pada sel Mast berikatan Urtikaria, Anafilaktik
dengan Ag, menstimuli degranulasi Asma,
Histamin. Relaksasi otot polos kapiler dan Syok
kontriksi otot polos saluran nafas

II IgG, Antibodi bereaksi dengan Ag yang berada Ketidak cocokan Sitotoksik

IgM pada membran. Aktivasi Komplemen, dan gol darah bergantung pada
menarik sel lekosit, lisis membran (transfusi) Ab (ADCC)

III IgG, Antibodi berikatan dengan Ag partikel Penyakit serum, Kompleks imun
IgM larut, membentuk kompleks yang beredar Glomerulonefritis
ikut sirkulasi, terperangkap, aktivasi akut. , SLE
komplemen, lisis membrane dan menarik
lekosit

IV Ly T Ag menstimuli Ly T-CD4, dihasilkan sitokin, Test Mantoux, Tipe lambat

mengaktifkan Ly T-CD8, makrofag. Timbul Tuberkel (TBC)
nekrosis, sebukan Ly dan Histiosit
(epiteloid), sel Datia