Biochemistry is the study of life on the molecular level.Therefore, biochemistry, as the name implies, is the chemistry of life. Life, at its most basic level, is a biochemical phenomenon including two basic characteristics: self- refresh (metabolism), and self-replication and self-assembly (expression and transmission of genetic information).
The 21th century is an era of life science. Lots of wonders are being created, and explosive information is being provided at an unprecedented speed. Biochemistry is a window opening to the world of life science. Thus, the knowledge of biochemistry which involves the study of chemical molecules and reactions in living organisms, and the elucidations of the nature of live phenomenon on the molecular level, is essential to medical students, as well as to the students of other related disciplines.
As is known to all, when biochemistry is taught in English, it will be double-beneficial to the chinese students and the students abroad, for they get trained in their professional language while learning biochemical knowledge. This is not only significant to students who want to expand their knowledge from other sources written in English, but also helpful to the students who are going to pursue their scientific career in the future.
functions of biomolecules ( Part I); the metabolism of substrates and their regulations (Part II); expression and transmission of genetic information, Gene Recombination & Gene Ingeneering (Part III); comprehensive topics (Part IV). Totally 180 teaching hours, including 113 for theory and 45 for experiment and 22 individual sdudy.
of demands should be met in different classes. That is----- emphasis means to memorize the knowledge basing on the understanding of the principle and to solve problems and practice applying the principle; difficulty means: not the emphasis but understand.
The specific three-dimensional structure of the protein in solution is called its tertiary structure. This is built up from primary and secondary structures by means of a number of bonding forces\u2474hydrogen bond;\u2475electrostatic bonds(salt links);\u2476hydrophobic interactions between hydrophobic R groups;\u2477disulfide bonds between cysteine residues.
\u248b Ma s t e r the amphoteric properties and isoelectric point (pI).
\u248c Ma s t e r the macromoleculer and colloidal behavior of protein solutions.
\u248d Know well denaturation of proteins.
\u248e Know well precipitation of proteins.
Emphasis: composition of proteins, structure of proteins, functions of protein.
Difficulty: structure of proteins.
Contents: composition of proteins, structure of proteins, propeties of proteins, fungction of proteins.
1. elementary composition.
2. hydrolysis products of nucleic acids.
The monomer units of nucleic acids are nucleotides. The basic componets of a nucleotide are nitrogenous base,
3. pentose sugars: ribose (only RNA) and 2-deoxyribose (only DNA).
4. nitrogenous bases
The DAN molecule contains A,G,C,and T, whereas RNA molecules contain A,G.C and U. Notice that T occurs
linked by 3\u2019-5\u2019-phosphodiester bonds.
The sequence of the nucleotides in polynucleotide strand is celled primary structure of nucleic acid.
2. The structure of DNA : the base composition of DNA; Chargaff,s rules; Waston-Crick model.
1. denaturation and renaturation of DNA.
2. renaturation and hybridization.
3. ultraviolet absorption.
Emphasis: composition, structure and function of nucleic acid.
Difficulty: structure and properties of nucleic acid.
Contents:composition of nucleic acids, structure of nucleic acids, properties of nucleic acids, function of nucleic
\u2488 Master conception of holoenzyme,coenzyme,active cente zymogen ,isoenzyme.
\u2489 Master the character of enzyme catalyzed chemical reaction.
\u248aMaster the structure and function of enzyme.
\u248b Know well kinetics of enzyme-catalyzed reactions
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