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Bio-chemistryCurriculum-1

Bio-chemistryCurriculum-1

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The curriculum outline of biochemistry
Total period 180 (Theory 113, Practice 45, Individual sdudy 22.)
Chapter
Contents
Total
period
Theoy
Chapter 1
Introduction, Structures and Functions of Proteins
12
7
5
Chapter 2
Structures and Functions of Nucleic Acids
14
8
5
Chapter 3
Enzymes
11
6
5
Chapter 4
Vitamins
4
4
Chapter 5
Carbohydrates Metabolisms
17
10
5
Chapter 6
Biological Oxidation
7
7
Chapter7
Metabolism of Lipids
17
10
5
Chapter8
Catabolism of Proteins
12
10
Chapter 9
Nucleotides Metabolism
6
6
Chapter 10 Biosynthesis of DNA
8
6
Chapter 11 Synthesis of RNA
14
7
5
Chapter 12 Biosynthesis of Protein
11
6
5
Chapter 13 Regulation of Gene Expression
9
7
Chapter 14 Gene Recombinant & Gene Ingeneering
10
8
Chapter 15 Blood Biochemistry
12
5
5
Chapter 16 Liver Biochemistry
13
6
5
Total
180
113
45
Intruduction to Biochemistry
1

Biochemistry is the study of life on the molecular level.Therefore, biochemistry, as the name implies, is the chemistry of life. Life, at its most basic level, is a biochemical phenomenon including two basic characteristics: self- refresh (metabolism), and self-replication and self-assembly (expression and transmission of genetic information).

The 21th century is an era of life science. Lots of wonders are being created, and explosive information is being provided at an unprecedented speed. Biochemistry is a window opening to the world of life science. Thus, the knowledge of biochemistry which involves the study of chemical molecules and reactions in living organisms, and the elucidations of the nature of live phenomenon on the molecular level, is essential to medical students, as well as to the students of other related disciplines.

As is known to all, when biochemistry is taught in English, it will be double-beneficial to the chinese students and the students abroad, for they get trained in their professional language while learning biochemical knowledge. This is not only significant to students who want to expand their knowledge from other sources written in English, but also helpful to the students who are going to pursue their scientific career in the future.

There are four parts in this program, and totally 16 chapters: the structures and

functions of biomolecules ( Part I); the metabolism of substrates and their regulations (Part II); expression and transmission of genetic information, Gene Recombination & Gene Ingeneering (Part III); comprehensive topics (Part IV). Totally 180 teaching hours, including 113 for theory and 45 for experiment and 22 individual sdudy.

In this syllabus, the contents of 16 chaptesr have been pointed out what kind

of demands should be met in different classes. That is----- emphasis means to memorize the knowledge basing on the understanding of the principle and to solve problems and practice applying the principle; difficulty means: not the emphasis but understand.

The Teaching of Theory
Chapter 1 Proteins: 7hours
\u2488 M as t e r the composition of proteins\uff1a
\u2474 Elementary composition
\u2475 The structural units(monomer units) of proteins \u2014 amino acid (aa,)
\u2489 Ma s t e r structure of proteins\uff1a
\u2474 the Basic structure of proteins\u2014\u2014polypeptide chain
The peptide bond is extremely important, since it is the main structural bond found in all protins.
\u2475 The levels of protein structure\uff1a
i.
the primary structure--The amino acid sequence of the polypeptide chain(and the presence of
disulfide bonds) of a protein is called the primary structure.
ii.
the secondary structure \u2014 conformations of polypeptide chains.
\u248a Know well tertiary structure \u2014three-dimensional shape of proteins.

The specific three-dimensional structure of the protein in solution is called its tertiary structure. This is built up from primary and secondary structures by means of a number of bonding forces\u2474hydrogen bond;\u2475electrostatic bonds(salt links);\u2476hydrophobic interactions between hydrophobic R groups;\u2477disulfide bonds between cysteine residues.

\u248b Ma s t e r the amphoteric properties and isoelectric point (pI).
\u248c Ma s t e r the macromoleculer and colloidal behavior of protein solutions.
\u248d Know well denaturation of proteins.
\u248e Know well precipitation of proteins.

\u2474 Salting out :The addition of high concentrations of neutral salts, such as (NH4)2SO4, Na2SO4, or NaCl, to an
2
aqueous solution of protein causes it to preciptate. This phenomenon is referred to as salting out.
\u2475 Organic solvents
\u2476Heavy metals
\u2477Certain acids
\u248f U n d ers t a n d the classification of proteins
\u2474 Simple protein
\u2475 Conjugated protein

Emphasis: composition of proteins, structure of proteins, functions of protein.
Difficulty: structure of proteins.
Contents: composition of proteins, structure of proteins, propeties of proteins, fungction of proteins.

Chapter 2 Nucleic Acids: 8 hours
\u2488 Ma s t e r the composition of nucleic acids

1. elementary composition.
2. hydrolysis products of nucleic acids.
The monomer units of nucleic acids are nucleotides. The basic componets of a nucleotide are nitrogenous base,

pentose, phosphoric acid.

3. pentose sugars: ribose (only RNA) and 2-deoxyribose (only DNA).
4. nitrogenous bases
The DAN molecule contains A,G,C,and T, whereas RNA molecules contain A,G.C and U. Notice that T occurs

only in DNA and U occurs only in RNA.
5. Nucleosides
A nucleotide is a phosphate ester of a nucleoside in which a molecule of phosphoric acid is esterified with one
of the free hydroxyl group of the pentose sugar.
\u2489 Ma s t e r the structure of nucleic acids
1. The basic structure of nucleic acids \u2014polynucleotide chain. The monoucleotides in DNA and RNA are

linked by 3\u2019-5\u2019-phosphodiester bonds.
The sequence of the nucleotides in polynucleotide strand is celled primary structure of nucleic acid.
2. The structure of DNA : the base composition of DNA; Chargaff,s rules; Waston-Crick model.

3. The structure of RNA: structure and function of mRNA; structure and function of tRNA and structure and
function of rRNA; base pair rules. The secondary structure of tRNA\u2014cloverleaf model.
\u248a Know well the properties of nucleic acids.

1. denaturation and renaturation of DNA.
2. renaturation and hybridization.
3. ultraviolet absorption.

Emphasis: composition, structure and function of nucleic acid.
Difficulty: structure and properties of nucleic acid.
Contents:composition of nucleic acids, structure of nucleic acids, properties of nucleic acids, function of nucleic

acids.
Chapter 3 Enzymes
6 hours

\u2488 Master conception of holoenzyme,coenzyme,active cente zymogen ,isoenzyme.
\u2489 Master the character of enzyme catalyzed chemical reaction.
\u248aMaster the structure and function of enzyme.
\u248b Know well kinetics of enzyme-catalyzed reactions

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