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X-Linked Inheritance
X-linked disorders are those in which the defective gene lies on the X sex chromosome. We inherit the sex chromosomes along with the other 44 (22 pairs) of non-sex chromosomes from our parents. If we inherit two copies of the X chromosome, we're female; an X and a Y, and we're male. X-linked disorders are most common in males as there is no second X chromosome carrying the normal copy to compensate. In males therefore a recessive gene can cause a genetic disorder. Females are less likely to be affected as they have the non-affected X chromosome as well. However, as only one X chromosome is active in each female cell at a time (one is switched off due to a process called Lyonisation), patches of affected tissue or organs can occur in females. Typical examples of X-linked disorders include haemophilia A, Duchenne muscular dystrophy. In such examples the sons of a noncarrier father and a carrier mother have a 50% chance of being affected. Daughters have a 50% chance of being carriers. top
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Genetic A lliance UK - 2012 All rights re se rve d. Page Last Update d: 20.10.2011
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