DRUGS CONTRAINDICATED IN PREGNANCY (part 1 of 2)

This chart represents information on select drugs that are contraindicated (Pregnancy category X) for women who are pregnant. This is not an inclusive list of products that carry that pregnancy category. Those drugs that are contraindicated at a certain phase of the pregnancy are listed next to the product name. For more information on specific drug monographs, see product entries or consult the manufacturer.
ALLERGIC DISORDERS None available CARDIOVASCULAR SYSTEM Advicor (niacin ext-rel/lovastatin) Altoprev (lovastatin) Bayer (aspirin) 3rd trimester Caduet (amlodipine/atorvastatin) Coumadin (warfarin sodium) Crestor (rosuvastatin) Ecotrin (aspirin) 3rd trimester Lescol (fluvastatin) Lescol XL (fluvastatin) Lipitor (atorvastatin) Mevacor (lovastatin) Pravachol (pravastatin) Pravigard PAC (buffered aspirin/ pravastatin) Vytorin (ezetimibe/simvastatin) Zocor (simvastatin) CENTRAL NERVOUS SYSTEM Dalmane (flurazepam HCl) Doral (quazepam) Estazolam Halcion (triazolam) Restoril (temazepam) Yaz (drospirenone/ethinyl estradiol) DERMATOLOGICAL DISORDERS Accutane (isotretinoin) Avage (tazarotene) Carac (fluorouracil) Efudex (fluorouracil) Estrostep Fe (norethindrone acetate/ethinyl estradiol) Ortho Tri-Cyclen 28 (norgestimate/ethinyl estradiol) Propecia (finasteride) Solage (mequinol/tretinoin) Solaraze (diclofenac sodium) 3rd trimester Soriatane (acitretin) SSD (silver sulfadiazine) Late pregnancy SSD AF (silver sulfadiazine) Late pregnancy Tazorac (tazarotene) MUSCULOSKELETAL DISORDERS Advil (ibuprofen) 3rd trimester Aleve (naproxen sodium) 3rd trimester Ansaid (flurbiprofen) Late pregnancy Arava (leflunomide) ENDOCRINE DISORDERS Arthrotec (diclofenac sodium/ Androderm (testosterone) misoprostol) Androgel (testosterone) Bayer (aspirin) 3rd trimester Android (methyltestosterone) Cataflam (diclofenac potassium) Late Delatestryl (testosterone enanthate) pregnancy Depo-testosterone (testosterone Celebrex (celecoxib) 3rd trimester cypionate) Choline magnesium trisalicylate Lupron (leuprolide acetate) Pregnancy at term Methitest (methyltestosterone) Dantrium (dantrolene) Daypro (oxaprozin) 3rd trimester Oxandrin (oxandrolone) Diflunisal 3rd trimester Striant (testosterone) Ecotrin (aspirin) 3rd trimester Supprelin LA (histrelin acetate) Equagesic (meprobamate/aspirin) Synarel (nafarelin) Evista (raloxifene HCl) Testim (testosterone) Feldene (piroxicam) Late pregnancy Testred (methyltestosterone) Lodine (etodolac) Late pregnancy Virilon (methyltestosterone) Mobic (meloxicam) 3rd trimester GASTROINTESTINAL TRACT Motrin (ibuprofen) 3rd trimester Nabumetone 3rd trimester Bellergal-S (phenobarbital/ergotamine tartrate) Nalfon (fenoprofen calcium) 3rd trimester Cytotec (misoprostol) Naprelan (naproxen) 3rd trimester INFECTIONS & INFESTATIONS Oruvail (ketoprofen) Late pregnancy Copegus (ribavirin) Prevacid Naprapac Flagyl (metronidazole) 1st trimester (lansoprazole/naproxen) 3rd trimester for trichomoniasis Probenecid + Colchicine Gantrisin (sulfisoxazole) 3rd Rheumatrex (methotrexate sodium) trimester Salsalate 3rd trimester Grifulvin V (griseofulvin) Soma Compound w. Codeine Macrobid (nitrofurantoin as (carisoprodol/aspirin/codeine) 3rd macrocrystals and monohydrate) trimester Pregnancy at term Voltaren (diclofenac sodium) Late Macrodantin (nitrofurantoin pregnancy macrocrystals) Pregnancy at term Pediazole NEOPLASMS (erythromycin/sulfisoxazole) 3rd Bexxar (tositumomab) trimester Casodex (bicalutamide) Rebetol (ribavirin) Eligard (leuprolide acetate) Rebetron (ribavirin/interferon alfa -2b) Estrace (estradiol) Tindamax (tinidazole) 1st trimester Plenaxis (abarelix) Virazole (ribavirin) Targretin (bexarotene) Viracept (nelfinavir mesylate) Thalomid (thalidomide)
(continued)

Tri-previfem (norgestimate/ethinyl estradiol) Tri-sprintec (norgestimate/ethinyl estradiol) Yaz (drospirenone/ethinyl estradiol)

DRUGS CONTRAINDICATED IN PREGNANCY (part 2 of 2)

Trelstar (triptorelan pamoate) Trexall (methotrexate) Vantas (histrelin acetate) NUTRITION Didrex (benzphetamine) Megace ES (megestrol acetate) Megace Suspension (megestrol acetate) OB/GYN ALL ORAL CONTRACEPTIVES ALL HORMONE REPLACEMENT THERAPY Advil (ibuprofen) 3rd trimester Aleve (naproxen sodium) 3rd trimester Aygestin (norethindrone acetate) Betadine douche (povidone-iodine) Bravelle (urofollitropin) Cataflam (diclofenac potassium) Late pregnancy Celebrex (celecoxib)3rd trimester Cetrotide (cetrorelix) Clomid (clomiphene citrate) Depo-subQ provera (medroxyprogesterone acetate) Endometrin (micronized progesterone) Ectopic pregnancy Flagyl (metronidazole) 1st trimester for trichomoniasis Ganirelex acetate Gonal-F (follitropin alfa) Lupron Depot (leuprolide acetate) Luveris (lutropin alfa) Menopur (menoptropins) Midol cramp (ibuprofen) 3rd trimester
*Not an inclusive list

Midol menstrual (acetaminophen/ caffeine/pyrilamine) 3rd trimester Midol PMS (acetaminophen/ pamabrom/pyrilamine) 3rd trimester Midol teen (acetaminophen/ pamabrom) 3rd trimester Mifeprex (mifepristone) Motrin (ibuprofen) 3rd trimester Naprelan (naproxen) 3rd trimester Ovidrel (choriogonadotropin alfa) Ponstel (mefenamic acid) Late pregnancy Repronex 150 IU (follicle-stimulating hormone/luteinizing hormone) Septra (sulfamethoxazole/ trimethoprim) 3rd trimester Serophene (clomiphene citrate) Synarel (nafarelin acetate) Tindamax (tinidazole) 1st trimester Zoladex (goserelin) PAIN & PYREXIA

Advil (ibuprofen) 3rd trimester Advil Migraine (ibuprofen) 3rd trimester Aleve (naproxen sodium) 3rd RESPIRATORY TRACT trimester None available Bayer (aspirin) 3rd trimester Cafergot (ergotamine tartrate/ UROGENITAL SYSTEM caffeine) Cataflam (diclofenac potassium) Late Avodart (dutasteride HCl) AVOID pregnancy HANDLING CAPSULES Celebrex (celecoxib) 3rd trimester Caverject (alprostadil) Combunox (oxycodone/ibuprofen) 3rd Edex (alprostadil) trimester Proscar (finasteride) AVOID D.H.E. 45 (dihydroergotamine HANDLING CRUSHED/BROKEN mesylate) TABLETS

Darvon Compound (propoxyphene HCl/ aspirin/caffeine) 3rd trimester Diflunisal 3rd trimester Excedrin Migraine (acetaminophen/aspirin/ caffeine) 3rd trimester Fiorinal (butalbital/aspirin/caffeine) 3rd trimester Fiorinal w. Codeine (butalbital/aspirin/ caffeine/codeine phosphate) 3rd trimester Ketorolac Late pregnancy Lodine (etodolac) Late pregnancy Migranal (dihydroergotamine mesylate) Motrin Migraine Pain (ibuprofen) 3rd trimester Percodan (oxycodone HCl/aspirin) 3rd trimester Ponstel (mefenamic acid) Late pregnancy Synalgos-DC (dihydrocodeine bititrate/ aspirin/caffeine) 3rd trimester Vicoprofen (hydrocodone bitartrate/ibuprofen) 3rd trimester

(created 1/2009)

PREGNANCY CATEGORIES
When pregnancy appears as a contraindication or precaution to the use of a drug it is usually qualified by a category. Cat. A: Adequate studies in pregnant women have failed to show a risk to the fetus in the first trimester and there is no evidence of risk in later trimesters. Cat. B: Animal studies have failed to show a risk to the fetus but there are no adequate studies in pregnant women; or animal studies have shown an adverse effect but human studies have not shown a risk to the fetus inthe first trimester and there is no evidence of risk in later trimesters. Cat. C: Animal studies have shown an adverse effect on the fetus but there are no adequate studies in humans, but the benefits may outweigh the risks; or there are no adequate human studies. Cat. D: Positive evidence of human fetal risk but the benefits may outweigh the risks. Cat. X: Animal or human studies have shown fetal abnormalities or toxicity and the risk outweighs the benefits.