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  • OHT Study - Factors Predicting Onset of POAG

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    This document summarizes two studies on glaucoma. The OHTS study found that using topical medications to lower IOP by at least 20% from baseline in patients with ocular hypertension reduced the risk of developing POAG by 60% over 5 years. Key risk factors for developing POAG included older age, higher IOP, thinner central corneal thickness, and visual field changes. The EMGT study compared immediate IOP lowering treatment versus no treatment in patients with newly detected open-angle glaucoma. It found that treatment reduced mean IOP by 25% and slowed progression of glaucoma, with the treated group taking on average 18 months longer to progress. Both studies showed that lowering IOP can delay or prevent

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    This document summarizes two studies on glaucoma. The OHTS study found that using topical medications to lower IOP by at least 20% from baseline in patients with ocular hypertension reduced the risk of developing POAG by 60% over 5 years. Key risk factors for developing POAG included older age, higher IOP, thinner central corneal thickness, and visual field changes. The EMGT study compared immediate IOP lowering treatment versus no treatment in patients with newly detected open-angle glaucoma. It found that treatment reduced mean IOP by 25% and slowed progression of glaucoma, with the treated group taking on average 18 months longer to progress. Both studies showed that lowering IOP can delay or prevent

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    31 views1 page

    OHT Study - Factors Predicting Onset of POAG

    Uploaded by

    mmpipi21
    This document summarizes two studies on glaucoma. The OHTS study found that using topical medications to lower IOP by at least 20% from baseline in patients with ocular hypertension reduced the risk of developing POAG by 60% over 5 years. Key risk factors for developing POAG included older age, higher IOP, thinner central corneal thickness, and visual field changes. The EMGT study compared immediate IOP lowering treatment versus no treatment in patients with newly detected open-angle glaucoma. It found that treatment reduced mean IOP by 25% and slowed progression of glaucoma, with the treated group taking on average 18 months longer to progress. Both studies showed that lowering IOP can delay or prevent

    Copyright:

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    OHT Study Factors Predicting Onset of POAG -OHTS designed to evaluate safety and efficacy of topical meds in delaying/preventing

    POAG -1636 pts w OHT and IOP 24-32 w/no evidence of glc damage; randomized to tx or observation -goal of tx was to achieve IOP <24 and 20% reduction from baseline IOP (IOP <18 not required) -60% reduced risk of POAG w topical meds -at 60 months risk of POAG was ~4.4% in txd group vs 9.5% in untxd group -CCT measurements obtained at F/U visitis, not during randomization; inverse relationship between CCT and development of POAG; 3 fold risk incr if CCT <555um -key risk factors: age, large vertical CD ratio, incr IOP, incr PSD on at least 2 VFs, thin CCT (<555um) -Hx of DM seemed to be a protective factor from onset of POAG (6/191 developed POAG)

    Early Manifest Glaucoma Trial (1992-2001) -compared the effect of immediate IOP lowering vs not treating on progression of newly detected OAG -255 pt (129 tx/126 controls) aged 50-80 (median 68) w/early glc, repeatable VF defects w/ONL on GHT, and median IOP of 20 -txd group received 360 trabeculoplasty plus betxolol drops bid -pts remained in untxd unless progression occurred F/u every 3 months, with stereo photos every 6 months -Tx reduced IOP by ~5mmHg (~25%); progression less frequent and occurred much later than untxd group -mean IOP reduced in tx group from 20.6 to 15.5 (25%) -larger progression in control group; mean time to progression=48 months for control; 66 months for txd group -Each mmHg decrease correlates to ~10% lower risk of progression -nuclear lens opacitites incr in txd group -study showed that reducing IOP can slow progression of glaucoma; also showed value of repeated reliable visual fields -no rigid target IOP was set in the EMGT -considerations: almost all participants were white with very early glaucoma and IOP <30

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