Assay of Paracetamol in Drug Preparations by HPLC (High Performance Liquid Chromatography) method *Chaerani Azizah Chemistry Education, Islamic

State University Syarif Hidayatullah Jakarta Abstract Paracetamol is an analgesic and antipyretic drug, its so popular and used to relieve headaches, out of breath, mild pain, and fever. Analgesics are drugs that can reduce or eliminate pain and eventually will give comfort to the people who suffer. Antipyretics is a drug that can lower a fever (high body temperature). In most cases (about 90%) have the effect of antipyretic analgesics. It is the purpose of this study to determine concentrations of paracetamol in drug preparation. Assay tests were Paracetamol (Acetaminophen) by HPLC (High Performance Liquid Chromatography) method using a reagent methanol : water (3 : 1) as mobile phase and using column Bondapack C18 10 m 3.9x300 mm as stationary phase in a sample of drug preparations. Assay of Paracetamol (Acetaminophen) in the drug preparations was calculated based on peak height Paracetamol (Acetaminophen) on the high standard peak area Paracetamol (Acetaminophen). In this study, Acetaminophen concentration of analysis results obtained in drug preparations have specifications Acetaminophen assay (95% -105%) and compatible with Pharmacopoeia Indonesia (FI) IV Edition of 1995, the tablet/caplet contains paracetamol (C8H9NO2) is not less than 90.0% and not more than 110.0%. In the conclusion of this research; Acetaminophen assay of 102.33%. Key words: acetaminophen, paracetamol, analgesics, HPLC