PHARMACOGENOMICS: Uses and Dangers

Definition: The study of how different genes react and dictate drug response and how these variations can be used to predict how a patient will react to certain drugs. Uses the genetic make up of a person to choose the drug that will best help a person.

Examples: Used to prescribe drugs but only for a few health problems. The most common use is for people who have HIV and they will test to see if a particular drug (Ziagen) will work with their body. Also used to prescribe a drug (Herceptin) for breast cancer patients and only for those patients whose tumors have a particular genetic profile.

Dangers and Risks: Making sure patients understand what they are doing: informed consent. Extensive information is required in order to test genes and how the body will respond. Must make sure these genetic markers dont appear in other research. Confidentiality concerns. Massive amounts of data are collected in order to study DNA and its reaction to drugs. Where is this information stored and is it safe?

References:
Facts About Pharmacogenomics: http://www.genome.gov/27530645 Pharmacogenomics and Ethics: http://www.scu.edu/ethics/practicing/focusareas/medical/ pharmacogenomics.html