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Viruses defined
Under attack!
(From Medical Microbiology, 4th ed., Murray, Rosenthal, Kobayashi & Pfaller, Mosby Inc., 2002, Fig. 65-1.)
Structures compared
From Medical Microbiology, 5th ed., Murray, Rosenthal & Pfaller, Mosby Inc., 2005, Fig. 6-4.
or
RNA
Capsid protein
Nucleocapsid
Nucleocapsid
Enveloped virus
Capsid symmetry
Icosahedral Helical
Naked capsid
Enveloped
http://www.ncbi.nlm.nih.gov/ICTVdb/Images/Ackerman/Animalvi/Adenovir/799-16.htm
Adenovirus Electron micrograph Foot and mouth disease virus Crystallographic model
http://virology.wisc.edu/virusworld/ICTV8/fmd-foot-and-mouth-ictv8.jpg
RNA
Protein
Caspar and Klug, Adv Virus Res. 1960;7:225-325
http://web.uct.ac.za/depts/mmi/stannard/fluvirus.html
Consequences
Adapted from Murray, P.R. Rosenthal K.S., Pfaller, M.A. (2005) Medical Microbiology, 5th edition, Elsevier Mosby, Philadelphia, PA Box 6-5
Consequences
Adapted from Murray, P.R. Rosenthal K.S., Pfaller, M.A. (2005) Medical Microbiology, 5th edition, Elsevier Mosby, Philadelphia, PA , Box 6-4
Subfamily
Genus
Type Species
Hosta
Borna disease virus Vesicular stomatitis Indiana virus Rabies virus Bovine ephemeral fever virus Infectious hematopoietic necrosis virus Lettuce necrotic yellows virus Potato yellow dwarf virus Lake Victoria marburgvirus Zaire ebolavirus
V V, I V V, I V P, I P, I V V
Mumps virus Newcastle disease virus Sendai virus Hendra virus Measles virus
V V V V V
V V
Fields Vriology (2007) 5th edition, Knipe, DM & Howley, PM, eds, Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia Table 2.2
Fields Vriology (2007) 5th edition, Knipe, DM & Howley, PM, eds, Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia Table 2.1
(+)mRNA
dsDNA
dsDNA
(+)mRNA
(+)RNA
(-)RNA
(+)RNA
(+)mRNA
dsRNA
(+)mRNA
dsRNA
(+)RNA
(+)mRNA
dsDNA ssDNA
(+)RNA
(+)mRNA
dsDNA
Virus growth
1,000 100,000 viruses/cell, 5 24 hours
From Schaechters Mechanisms of Microbial Disease; 4th ed.; Engleberg, DiRita & Dermody; Lippincott, Williams & Wilkins; 2007; Fig. 31-8
Classification
Many virus families, organized by structure and biology
Replication
Generic scheme Varying strategies depending on nucleic acid