J AMES

P. S MITH
404 Warren Rd #2 Ithaca, NY 14850
jps336 [at] cornell.edu 610-316-0463 www.jamespaulsmith.com

EDUCATION
Cornell University, Ithaca, NY
Ph.D., Mechanical Engineering (major), Computational Science Engineering (minor)
Dissertation: Biosensor Design Optimization using Computational Fluid Dynamics
Committee: Brian J. Kirby (chair), Peter J. Diamessis, Donald L. Koch

Expected Fall 2014

Cornell University, Ithaca, NY

M.S., Mechanical Engineering

August 2013

Clarkson University, Potsdam, NY

B.S., Aeronautical Engineering, Mechanical Engineering

May 2008

PROFESSIONAL EXPERIENCE
Graduate Research Assistant
Cornell Micro/Nanofluidics Laboratory
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY
Research: Microscale fluid dynamics for circulating tumor cell capture
Advisor: Brian J. Kirby

2009present

Mechanical Engineer
Lockheed Martin Space Systems, Valley Forge, PA
Projects: Advanced Stirling Radioisotope Generator (ASRG), funded by NASA and U.S. DOE

Hypersonic Technology Vehicle 2 (HTV-2), funded by DARPA and USAF

20082009

Mechanical Engineering Intern

Lockheed Martin Space Systems, Valley Forge, PA
Project: Hypersonic Technology Vehicle (HTV), funded by DARPA

2006, 2007

ADDITIONAL LEADERSHIP AND TEAMWORK EXPERIENCE

Co-Founder and Chief Science Officer
20132014
Captura Diagnostics, Inc., Ithaca, NY
Co-founded and managed a startup to commercialize microfluidic rare cell capture technologies; wrote grant
proposals and presented funding pitches; secured funding from Excell Partners and Centerstate CEO.

President
2013present
Vice President
20122013
Member, Board of Directors
2009present
East Hill Flying Club, Ithaca, NY
Managed the operation of a nonprofit member-owned cooperative with eight single-engine aircraft, $500,000 in
annual revenue, and 250 members

www.jamespaulsmith.com

Aug. 6, 2014

James P. Smith

Graduate Engineering Student Representative

20112013
Student Library Advisory Council, Cornell University, Ithaca, NY
Advised the University Librarian and her staff on the needs of graduate engineering students, especially as those
needs related to library downsizing, access to research journals, and the transition to digital media
STEM Education Outreach for Pre-K to 2nd grade students
20112012
Fassett Elementary School, Elmira, NY
Organized and led hands-on engineering activities in an after-school program for underprivileged students,
coordinated through the Economic Opportunity Program of Elmira
Peer reviewer for various technical journal submissions
International Journal of Heat and Mass Transfer, Chemical Engineering Science, and Biophysical Journal

various

PUBLICATIONS
Journal Publications
1. Huang C, Smith JP, Saha TM, Rhim AD, Kirby BJ. Characterization of microfluidic shear-dependent
EpCAM immunocapture and enrichment of pancreatic cancer cells from blood cells with dielectrophoresis.
Biomicrofluidics, 2014 [DOI, PDF]
2. Smith JP, Lannin TB, Syed YA, Santana SM, Kirby BJ. Parametric control of collision rates and capture
rates in geometrically enhanced differential immunocapture (GEDI) microfluidic devices for rare cell
capture. Biomedical Microdevices, 16(1):143151, 2014 [DOI, PDF]
3.

Gleghorn JP, Smith JP, Kirby BJ. Transport and collision dynamics in periodic asymmetric obstacle arrays:
rational design of microfluidic rare cell immunocapture devices. Physical Review E, 88(3):032136, 2013
[DOI, PDF]

4. Zhu B, Smith JP, Yarmush ML, Nahmias Y, Kirby BJ, Murthy SK. Microfluidic enrichment of mouse
epidermal stem cells and validation of stem cell proliferation in vitro. Tissue Engineering C, 19(10):765773,
2013 [DOI, PDF]
5. Smith JP, Barbati AB, Santana SM, Gleghorn JP, Kirby BJ. Microfluidic transport in microdevices for rare
cell capture. Electrophoresis, 33:31333142, 2012 [DOI, PDF]
6. Kirby BJ, Jodari M, Loftus MS, Pratt ED, Chanel-Vos C, Gakhar G; Gleghorn JP, Santana SM, Liu H, Smith
JP, Tagawa ST, Bander NH; Nanus DM, Giannakakou P. Functional characterization of circulating tumor
cells with a prostate-cancer-specific microfluidic device. PLoS ONE, 7(4):e35976, 2012 [DOI, PDF]
Invited Articles
1. Smith JP, Gleghorn JP, Kirby BJ. Particle transport in ordered geometric arrays: separation and capture.
Newsletter of the American Electrophoresis Society, 15(2), 2010 [PDF]

PRESENTATIONS
Conference Presentations
1. Smith JP, Gleghorn JP, Godla ME, Huang C, Lannin TB, Pratt ED, Santana SM, Thege FI, Kirby BJ.
Circulating tumor cell (CTC) cancer biomarkers using geometrically enhanced differential immunocapture
(GEDI) microdevices. Society for Lab Automation and Screening 2014, San Diego, CA
2. Huang C, Smith JP, Liu H, Bander NH, Kirby BJ. Enrichment of prostate cancer cells from blood cells with
a hybrid dielectrophoresis and immunocapture microfluidic system. MicroTAS 2013, Freiburg, Germany
www.jamespaulsmith.com

Aug. 6, 2014

James P. Smith

3.

Huang C, Smith JP, Liu H, Bander NH, Kirby BJ. A hybrid dielectrophoresis and immunocapture system
for enhanced capture of circulating tumor cells. BMES 2013, Seattle, WA

4. Huang C, Smith JP, Kirby BJ. A hybrid dielectrophoresis and immunocapture microfluidic system for
enhanced rare cell capture. Cornell NanoScale Science & Technology Facility Annual Meeting 2013, Ithaca,
NY.
5. Kirby BJ, Gleghorn JP, Godla ME, Huang C, Lannin TB, Pratt ED, Santana SM, Smith JP, Syed SA, Thege FI.
Capture and interrogation of circulating tumors cells by use of geometrically enhanced differential
immunocapture (GEDI) microfluidic devices. Gordon Research Conference on Physics and Chemistry of
Microfluidics 2013, Lucca, Italy
6. Smith JP, Gleghorn JP, Kirby BJ. Particle collision dynamics in periodic asymmetric microfluidic obstacle
arrays for rare cell capture. APS Division of Fluid Dynamics Fall Meeting 2012, San Diego, CA
7.

Pratt ED, Gleghorn JP, Loftus M, Jodari M, Santana SM, Smith JP, Stepansky A, Giannakakou PA, Hicks J,
Nanus DM, Rhim A, Stanger B, Kirby BJ, Functional and genetic analysis of CTCs captured with GEDI
microdevices. World CTC Summit Boston 2013, Boston, MA

8. Kirby BJ, Pratt ED, Santana SM, Smith JP, Gleghorn JP, Liu H, Bander NH, Jodari M, Loftus M, Nanus DM,
Giannakakou PA, Functional characterization of drug-target engagement on high-purity CTCs correlate
with patient progression. BMES 2011, Hartford, CT
9. Kirby BJ, Pratt ED, Santana SM, Smith JP, Gleghorn JP, Jodari M, Gakhar G, Loftus M, Liu H, Bander NH,
Nanus DM, Giannakakou PA, Functional characterization of drug-target engagement on high-purity CTCs
correlate with patient progression. MicroTAS 2011, Seattle, WA
10. Pratt ED, Santana SM, Smith JP, Gleghorn JP, Liu H, Blattner M, Bander NH, Rubin MA, Nanus DM,
Giannakakou PA, Kirby BJ, Circulating tumor cell release by use of novel immunocapture chemistry in
GEDI microdevices, MicroTAS 2011, Seattle, WA
11. Smith JP, Gleghorn JP, Kirby BJ. Transport and collision dynamics in GEDI cell capture microdevices.
Gordon Research Conference on Physics and Chemistry of Microfluidics 2011, Waterville Valley, NH
12. Smith JP, Gleghorn JP, Kirby BJ. Circulating tumor cell collision dynamics in geometrically enhanced
differential immunocapture (GEDI) microdevices. ASME International Mechanical Engineering
Conference and Exposition 2010, Vancouver, BC
13. Gleghorn JP, Smith JP, Kirby BJ. Particle collision dynamics in microfluidic obstacle arrays. Annual
meeting of the American Institute of Chemical Engineers 2010, Salt Lake City, UT
14. Gleghorn JP, Santana SM, Pratt ED, Smith JP, Lofthus MS, Jodari-Karimi M, Liu H, Bander NH, Nanus DM,
Giannakakou PA, Kirby BJ. Cancer cell assays by use of immunocapture, subcellular imaging, and
programmed cell release in GEDI microdevices. 14th International Conference on Miniaturized Systems
for Chemistry and Life Sciences 2010, Groningen, The Netherlands
15. Gleghorn JP, Smith JP, Kirby BJ. Collision dynamics in geometrically enhanced differential immuno-
capture devices for rare cell capture. 14th International Conference on Miniaturized Systems for
Chemistry and Life Sciences 2010, Groningen, The Netherlands
16. Smith JP, Gleghorn JP, Kirby BJ. Particle collision dynamics in geometrically enhanced differential
immunocapture microdevices. 10th New York Complex Matter Workshop, June 2010, Ithaca, NY
Invited Presentations
1. Smith JP, Gleghorn JP, Kirby, BJ. Cell collision dynamics for microfluidic rare cell capture. Cornell SiGMA
lecture series, May 5 2011, Ithaca, NY.
2. Smith JP, Gleghorn JP, Kirby BJ. Particle collision dynamics for microfluidic rare cell capture. Cornell
Fluid Dynamics Seminar series, April 19, 2011, Ithaca, NY.
www.jamespaulsmith.com

Aug. 6, 2014

James P. Smith

AWARDS AND HONORS

Poster Merit Award
Gordon Research Conference on Physics and Chemistry of Microfluidics, Waterville Valley, NH

2011

National Science Foundation Graduate Research Fellowship

Honorable Mention

2010

Best Poster Award

ASME International Mechanical Engineering Congress and Exposition, Vancouver, BC

2010

Olin Endowed Fellowship

Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY

2009

Tau Beta Pi Engineering Honor Society

Clarkson University, Potsdam, NY

2007

TEACHING EXPERIENCE
Graduate Teaching Assistant, Heat Transfer (MAE 3240)
Spring 2011
Graduate Teaching Assistant, Introductory Fluid Mechanics (MAE 3230)
Fall 2010
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY
Responsibilities: Conducted lectures, recitations and office hours, hold exam review sessions, and grading duties
for a class of9799 undergraduate students

www.jamespaulsmith.com

Aug. 6, 2014