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Pathophysiology Osteosarcoma
Pathophysiology Osteosarcoma
Osteosarcoma is a malignant mesenchymal sarcoma characterized by the direct formation of bone or osteoid by tumor cells. Osteosarcoma is subclassified depending on the histologic characteristics of the cells. When the majority of the cells produce osteoid, the tumor is called osteoblastic. Where production of chondroid matrix is predominant, the tumor is classified as a chondroblastic osteosarcoma. When spindle cells are in the majority and little matrix is formed, the term fibroblastic osteosarcoma is used.