Xalatan eye drops are sterile until opened.

The bottles contain a preservative that helps keep the eye drops sterile once they are in use. However, any medicine remaining in the bottle after the bottle has been open for four weeks or more is likely to be contaminated with germs and should no longer be used. Dispose of carefully, preferably by returning to your pharmacy. You may find it helpful to write the date of first opening on the packet.

http://www.netdoctor.co.uk/seniors-health/medicines/xalatan-eye-drops.html

Latanoprost (Xalatan) Prior to dispensing and opening, store unopened bottles in refrigerator at 36F to 46F (2C to 8C). During shipment, unopened bottle stable at up to 104 o F (40 o C) for no more than eight days. After first use, store at a room temperature not to exceed 77F (25C) for up to 6 weeks. Off-label information indicates unopened bottle stable when maintained at continuous room temperature 77 o F (25 o C) for 12 months.

6 Contact manufacturer.*** http://www.ashp.org/DocLibrary/Policy/PatientSafety/FrozenDrugs.pdf