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1. theory of the abnormalities of placental vascularization 2. Theory of ischemic placenta, free radicals, and endothelial dysfunction 3. Theory of intolerant immunology 4. The theory of cardiovascular adaptation and genetic 5. Theory of nutritional deficiencies 6. Theory of inflammatory
HLA-G 1 tropoblas cant invade the muscle layer of the spiral arteries blood suply vasokonstriksi rigid fetus ischemic oxidant = love fatty acid
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endothelial damage
Prostatglandin Endothelin vasokostriktor>>> vasodilatator platelet aggregation thromboxane Permeability
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Anti-hypertensive drugs
- Acute Therapy Blockers Atenolol, labetalol Calcium channel blockers 3-8 x 10 mg nifedipine / oral ISDN - Maintenance Therapy Simpatolitik centrally acting drugs methyldopa blockers atenolol, labetalol Calcium channel blockers nifedipine