Autoimmun

e Diseases

* :
)Auto(
( )Autoimmunity


( )Autoimmune diseases
.


( )Bacteria


( )Viruses








Inflammation)
(




( Multiple
)Sclerosis;MS
s disease)
Crohn(
Systemic Lupus (
)Erythematosus;SLE

SLE







(.)Diabetes Mellitus Type 1

.

*




()Infectious diseases


( )AIDS.

( )Psoriasis


.

( )Aging ( )Pregnancy
( )Chronic stress

(.)Hormones
*

( )Pathogens

( )Antigens
.

* :

( )Leukocytes
( )Lymphoytes


( )B-cells (T-
cells)




T-cell receptor)
(

Major(
)Histocompatibility Complex ;MHC

)Antibodies
(

( )Mark




Phagocytes
Macrophages
.Neutrophils

* :

( )molecules Reactive oxygen intermediate





( )Wegener granulomatosis

( )Joints
( )Inflammation
.

* :
)MHC(

MHC

MHC
Antigen presenting cells)
(
MHC


)Co-stimulatory molecules(


.

( )Tolerance

*
(:)Cytokines and Chemokines


MHC
( )Cytokines

 Chemokines)
(







(.)Scleroderma

.
* (:)Antibodies
( )B-cells

( )Messenger cytokine
.
* (:)Autoantibodies







)Myasthenia gravis(



( )Pemphigus




.
*
(:)System Immune Complexes and the Complement


Immune (
)complex

( )Complement



















.
* :

.

* :

* :











.

( )Inflammation

.

( Immunosuppressive
)medications
()Corticosteroids
( )Methotrexate
( )Cyclophosphamide)Azathioprin(
)Cyclosporin(


)Infections(
.


( )Remission


.

* :
:)Rheumatoid arthritis(

)Synovium(

)Osteoarthritis(

( )Degenerative
.

)Sjogren's Syndrome(

.
() : 1

:

* .
* .
* .
* .

* .
* .
* .
*

* .
* .
* .
:
* .
* .
*.
* .

* .
* .
* .
*
*
.

:
*.
*
* .
.

* .
*() .
* .
*
.
* .
.

(:)Sclerosis Multiple

)Nervous System Central(

( )Paralyses
( )Beta Interferon

.

077
.

(:)Type 1 Diabetes Mellitus

1 077

(:)Inflammatory Bowel Disease

Crohn( )s disease
)Ulcerative colitis(













( )Osteoporosis



.

(:)Systemic Lupus Erythematosus; SLE

( Anti-inflammatory
)medications


.

(:)Psoriasis

( )Systemic :

(:)Scleroderma



Raynaud( s
)phenomenon

(:)Autoimmune Thyroid Diseases

Hashimoto( s
)thyroiditis (Graves )disease



( )Hyperthyroidism
( )Hypothyroidism

.

* :

.
* Bibliography:
References for this article are available from

ACML on request.