MAPK signaling pathway

Inflammatory cytokines (e.g. TNFB, FASL, IL-1) Growth factors Activated GPCR Stress (UV irradiation)

+P

RTK

+P

+P

+P

+P

+P

+P +P +P +P

-P +P -P +P

+P

-P -P +P +P

+P

Stress response
+P +P +P +P +P +P +P +P +P +P +P +P +P

Translation initiation

+P

MK2 c-FOS STAT ELK c-JUN c-JUN CREB ATF2 SP-1 c-MYC

Growth, development, proliferation

Inflammation, apoptosis, differentiation, proliferation

Learn more at www.invitrogen.com/mapk.

Your path to performance

Empower your research today using Invitrogens comprehensive portfolio of products and services to investigate the MAPK pathway: everything from high-quality reagents for basic research and assay development, labeling chemistries, validated biochemical and cell-based assays, to world-class proling and screening services. For a complete list of products and services for analysis of the MAPK pathway, visit www.invitrogen.com/mapk.

Product
Antibodies ERK1 ERK1/2 ERK1/2 ERK1/2 [pTpY185/187] ERK1/2 [pTpY185/187] Alexa Fluor 488 ERK1/2 [pTpY202/204] ERK1/2 Western Blot Kit ERK2 ERK3 ERK5/BMK1 ERK5/BMK1 [pTpY218/220] JIP1 (N-Term) JIP1/2 (SH3) JNK1 JNK1/2 JNK1/2 [pTpY183/185] JNK2 MAPK Sampler Pack MAPKAPK2 MAPKAPK2 [pT334] MAP3K8 [pT290] MEK1 MEK1 [pT292] MEK1 [pS298] MEK1 [pT386] MEK1/2 [pS222] MEK1/2 [pSpS218/222]/[222/226] MEK2 (N-Term) MEK2 [pT394] MEK3 MEK3/6 [pSpT189/193]/[207/211] MEK4 [pSpT257/261] MEK7 [pSpT271/275] MEKK1 MKK6 MKK7 MLK3 [pTpS277/281] p38 MAPK p38 MAPK [pTpY180/182] p38 MAPK Western Blot Kit p38-2 MAPK RSK1 RSK1[pSpS221/227]

Cat. no.
138600 44654G 136200 44680G 44680A1 368800 BHO0021 134800 324100 44688G 44612G 345200 345300 359800 AHO1362 44682G AHO1162 44683G AHO1242 44516G 441370G 133500 44458G 44460G 44462G 44452 44454G 44467M 44466G 326900 44470 44474 44478 513400 327100 327000 44936 331300 44684G BHO0011 338700 AHO1472 44924G

Product
ELISA and phosphoELISA CREB (Total) ELISA Kit CREB [pS133] phosphoELISA Kit ERK 1/2 (Total) ELISA Kit ERK1/2 [pTpY185/187] phosphoELISA Kit HSP27 (Total) HSP27 [pS82] phosphoELISA Kit JNK1/2 (Total) ELISA Kit JNK1/2 [pTpY183/185] phosphoELISA Kit c-Jun [pS73] phosphoELISA Kit MEK1 (Total) ELISA Kit MEK1 [pSpS218/222] phosphoELISA Kit p38 (Total) ELISA Kit p38 [pTpY180/182] phosphoELISA Kit Luminex assays Akt, JNK1/2, p38 MAPK Total 3-Plex Panel Akt, JNK1/2, p38 MAPK Phospho 3-Plex Panel ERK1/2 (Total) Singleplex Bead Kit ERK1/2 [pTpY185/187] Singleplex Bead Kit JNK1/2 (Total) Singleplex Bead Kit JNK1/2 [pTpY183/185] Singleplex Bead Kit p38 Total Singleplex Bead Kit p38 [pTpY180/182] Singleplex Bead Kit Proteins MAP2K1 (MEK1) MAP2K1 (MEK1) Mutant MAP2K2 (MEK2) MAP2K3 (MEK3) MAP2K6 (MKK6) MAP2K6 (MKK6) S207E T211E MAP3K10 (MLK2) MAP3K11 (MLK3) MAP3K14 (NIK) MAP3K2 MAP3K3 (MEKK3) MAP3K5 (ASK1) MAP3K7/MAP3K7IP1 (TAK1/TAB1) MAP3K8 (COT1) MAP3K9 (MLK1) MAP4K2 MAP4K4 MAP4K5 (KHS1) MAPK1 (ERK2) MAPK3 (ERK1)

Cat. no.
KHO0231 KHO0241 KHO0081 KHO0091 KHO0331 KHO0341 KHO0121 KHO0131 KHO0841 KHO0291 KHO0321 KHO0061 KHO0071

Product
MAPK8 (JNK1) MAPK9 (JNK2) MAPK10 (JNK3) MAPK11 (p38b) MAPK12 (p38g) MAPK13 (p38d) MAPK14 (p38a) MAPKAPK2 MAPKAPK3 MAPKAPK5 (PRAK) RPS6KA3 (RSK2) LanthaScreen phosphospecific Tb-labeled antibodies and substrates Tb-anti-ERK2 [pTpY185/187] antibody Tb-anti-ATF2 [pT71] Antibody

Cat. no.
PV3319 PV3620 PV4563 PV3679 PV3654 PV3656 PV3304 PV3317 PV3299 PV3301 PV3323

PV5269 PV4451 PV4445 PV4453 PV4446 PV4813 PV4812

LHO0051 LHO0061 LHO0231 LHO0241 LHO0071 LHO0081 LHO0031 LHO0041

GFP-ATF2 Substrate Tb-anti-cJun [pS73] Antibody GFP-cJun Tb-anti-MAP2K1 [pS217/221] Antibody Fluorescein-MAP2K1 Z-LYTE kinase assays Z-LYTE Ser/Thr 3 Peptide Z-LYTE Ser/Thr 4 Peptide Z-LYTE Ser/Thr 7 Peptide Z-LYTE Ser/Thr15 Peptide

PV3176 PV3177 PV3180 PV3799

PV3303 P3099 PV3615 PV3662 PV3318 PV3293 PV3877 PV3788 PV4902 PV3822 PV3876 PV3809 PV4394 PV4313 PV3787 PV4211 PV3687 PV3682 PV3313 PV3311

Omnia kinase assays Omnia S/T Peptide 3 Omnia S/T Peptide 6 Omnia S/T Peptide 7 Omnia S/T Peptide 8 Omnia S/T Peptide 9 Omnia S/T Peptide 10 Omnia S/T Peptide 17 Omnia S/T Peptide 29 Omnia S/T Peptide 30 Cell-based assays LanthaScreen ERK2 A375 cells LanthaScreen ERK2 U2OS cells Kinase inhibitors IBMX Inhibitor PD98059 Inhibitor SB 202190 Inhibitor SB203580 Inhibitor SP600125 Inhibitor U0126 Inhibitor PHZ1124 PHZ1164 PHZ1243 PHZ1253 PHZ1264 PHZ1283 K1798 K1587 KNZ1031 KNZ1061 KNZ1071 KNZ1081 KNZ1091 KNZ1101 KNZ1171 KPZ1291 KPZ1301

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