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Title 40--Protection of Environment CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PART 174--PROCEDURES AND REQUIREMENTS FOR PLANTINCORPORATED PROTECTANTS
174.1 174.3 174.9 174.21 174.25 174.71 Scope and purpose. Definitions. Confidential business information claims for plant-incorporated protectant submissions. General qualifications for exemptions. Plant-incorporated protectant from sexually compatible plant. Submission of information regarding adverse effects.

174.451 Scope and purpose. 174.475 Nucleic acids that are part of a plant-incorporated protectant; exemption from the requirement of a tolerance. 174.479 Pesticidal substance from sexually compatible plant; exemption from the requirement of a tolerance. 174.480 Scope and purpose. 174.485 Inert ingredients from sexually compatible plant.
mino acid homology to known toxins Heat Stability test protein is inactivated against susceptible pest species when heated Lack of mammalian toxicity at high levels of exposure to the pure PIP protein (oral toxicity test) Safety of the products at levels well above maximum possible exposure levels that are reasonably anticipated in the crops Allergenicity Codex Standard: Weight of evidence approach Factors considered: Source of the trait Prevalence in food Amino acid sequence similarity with known allergens Biochemical properties of the protein In vitro digestibility (gastric / intestinal) No single predictive criterion