The study evaluated the antidiabetic and antioxidant effects of the methanol extract of Swietenia mahagoni bark in streptozotocin-induced diabetic rats. Oral administration of the extract at doses of 25 and 50 mg/kg body weight for 15 days significantly reduced blood glucose levels and restored body weight in diabetic rats. The extract also demonstrated antioxidant effects by decreasing levels of TBARS and increasing levels of GSH and CAT activity, indicating reduced free radical formation in the liver and kidney tissues of diabetic rats. The findings showed that the extract has significant hypoglycemic and antioxidant activity in diabetic rats.
The study evaluated the antidiabetic and antioxidant effects of the methanol extract of Swietenia mahagoni bark in streptozotocin-induced diabetic rats. Oral administration of the extract at doses of 25 and 50 mg/kg body weight for 15 days significantly reduced blood glucose levels and restored body weight in diabetic rats. The extract also demonstrated antioxidant effects by decreasing levels of TBARS and increasing levels of GSH and CAT activity, indicating reduced free radical formation in the liver and kidney tissues of diabetic rats. The findings showed that the extract has significant hypoglycemic and antioxidant activity in diabetic rats.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOCX, PDF, TXT or read online from Scribd
The study evaluated the antidiabetic and antioxidant effects of the methanol extract of Swietenia mahagoni bark in streptozotocin-induced diabetic rats. Oral administration of the extract at doses of 25 and 50 mg/kg body weight for 15 days significantly reduced blood glucose levels and restored body weight in diabetic rats. The extract also demonstrated antioxidant effects by decreasing levels of TBARS and increasing levels of GSH and CAT activity, indicating reduced free radical formation in the liver and kidney tissues of diabetic rats. The findings showed that the extract has significant hypoglycemic and antioxidant activity in diabetic rats.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOCX, PDF, TXT or read online from Scribd
Antidiabetic and antioxidant activity of Swietenia mahagoni in streptozotocin-induced diabetic rats.
Panda SP, Haldar PK, Bera S, Adhikary S, Kandar CC. Source Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. Abstract CONTEXT: Swietenia mahagoni L. Jacq. (Meliaceae) is a medium to large evergreen tree native to Southern Florida, Cuba, The Bahamas, Hispaniola, and Jamaica. OBJECTIVE: To evaluate the antidiabetic and antioxidant potential of S. mahagoni bark. MATERIALS AND METHODS: In the present study, the antidiabetic activity of the methanol extract of S. mahagoni (MESM) bark in streptozotocin (STZ; 65 mg/kg body weight)-induced diabetic rats was evaluated. Glibenclamide (0.5 mg/kg; orally) was taken as the reference drug. The blood glucose levels and body weights were measured every 5th day over a period of 15 days. Antioxidant effects were assayed in diabetic rats by estimating thiobarbituric acid reactive substances (TBARS), glutathione (GSH), and catalase (CAT) levels. RESULTS AND DISCUSSION: Oral administration of MESM at the doses of 25 and 50 mg/kg b.w. resulted in a significant (p < 0.001) reduction in blood glucose levels in diabetic rats. Body weights were significantly (p < 0.001) reduced in STZ-induced diabetic rats when compared to normal rats, while the extract significantly restored body weight. The present study was further undertaken to evaluate the antioxidant activity of MESM in STZ-induced diabetic rats. Decreased levels of TBARS and increased levels of GSH and CAT activity indicated a reduction in free radical formation in tissues such as the liver and kidney of diabetic rats. CONCLUSION: These findings showed the significant hypoglycemic and antioxidant activity of the extract (MESM) in diabetic rats.
Effect of Green Tea Consumption On Level of Glucose, Lipid Profile and Kidney Functions in Alloxan Induced-Diabetic Rats Abd-Elraheim A. Elshater Muhammad M. A. Salman Mahrous M. A. Moussa