CHEE 440 Tutorial 2 Questions 1. 100 mg of a drug are injected by i.v. into a student volunteer.

After 45 minutes, a blood sample is taken and the plasma concentration of the drug found to be 18 g/mL. If the half-life of the drug is 60 minutes, calculate the drugs volume of distribution. 2. For the same drug as question 1, the minimum effective concentration is 5 ng/mL. The same mass of drug is given as a tablet to another student volunteer, but only 80% of the administered drug is absorbed. The absorption rate constant for the drug is 0.10 min-1. When should the next tablet be taken to keep the drug concentration in the therapeutic window?