The most prescribing statin in the world

Atorvastatin, a lipid lowering agent is ranked as top selling pharmaceutical generic in 2011. Due to its pleotropic effects it is also the most choice able statin to the Bangladeshi doctors for the management of hypercholesterolemia

Avator Generic name : Atorvastatin

Therapeutic Class : Lipid Lowering Agent Naming : Atorvastatin
Dosage form Tablet Strength 10mg Pack Size 30S Unit Price 10.00

Brand name :

Mode of action :
Avator Inhibits HMG-CoA reductase Reduces conversion of HMG-CoA to mevalonate, Decreases Cholesterol Synthesis in liver Increases no. of LDL receptor on hepatocyte Decreases LDL in blood
*HMG CoA= Hydroxy Methyl Glutaryl- Coenzyme A

Indications:

Treatment : Hypercholesterolemia Mixed Dyslipidemia Hypertriglyceridemia

Prevention : Atherosclerosis Hypertension Angina Stroke Myocardial Infarction

Dosage and Administration:

Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to max. 80 mg once daily; Child 1018 years : Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 20 mg once daily.

Major Brands
Brand Name Atova Company Beximco MRP/Tab 10.00

Anzitor
Divastin TCL-R Lipicon Tiginor

Square
Drug Int. Aristopharma Sk+F Incepta

10.04
10.00 10.00 10.00 10.00

Target Doctors Cardiologist Diabetologist Medicine Specialist Neurologist General Physician

Unique Selling points :

Reduces Total cholesterol, LDL cholesterol and triglyceride but increases HDL cholesterol significantly
Total cholesterol LDL cholesterol Triglyceride HDL cholesterol : 29-45% (From baseline) : 39-60% : 19-37% : 5-6%

Provides fastest onset of clinical benefit

Atorvastatin Lovastatin Simvastatin : : : Within 2 weeks Within 1 year Within 2 year

Unique Selling points :

Shows positive dose-response relationship over the range of 10-80 mg

Stops the growth of plaques in artery walls

Unique Selling points :

Safe and efficacious in patients aged 65-75 years Safe and efficacious in patients with type 2 diabetes
(37% reduction rate in LDL-C)

Unique Selling points :

Safe for long term use
(4 years)

Well tolerated in patients with renal dysfunction

(No dose adjustment)

Guidelines :
1. Statin Therapy should be given to achieve target LDL is 100mg/dL 1. Dose should be increased if LDL level 100mg/dL is not achieved

Statin should be initiated to achieve target LDL is 100mg/dL