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  • Asthma Pathophysiology: Genetic Factors and Chemical Mediators

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    Ejie Boy Isaga
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    Asthma is caused by genetic and environmental factors that lead to bronchial mast cell degranulation and the release of chemical mediators, causing inflammation and bronchospasm. This results in wheezing, coughing, and shortness of breath from mucus production and airway obstruction. While treatments like bronchodilators provide relief, severe or untreated asthma can lead to a medical emergency from complete airway blockage.

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    physiography

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    PATO (Asthma)

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    Asthma is caused by genetic and environmental factors that lead to bronchial mast cell degranulation and the release of chemical mediators, causing inflammation and bronchospasm. This results in wheezing, coughing, and shortness of breath from mucus production and airway obstruction. While treatments like bronchodilators provide relief, severe or untreated asthma can lead to a medical emergency from complete airway blockage.

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    10 views1 page

    Asthma Pathophysiology: Genetic Factors and Chemical Mediators

    Uploaded by

    Ejie Boy Isaga
    Asthma is caused by genetic and environmental factors that lead to bronchial mast cell degranulation and the release of chemical mediators, causing inflammation and bronchospasm. This results in wheezing, coughing, and shortness of breath from mucus production and airway obstruction. While treatments like bronchodilators provide relief, severe or untreated asthma can lead to a medical emergency from complete airway blockage.

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    PATOPHYSIOLOGY Predisposing Factor: -Genetic -Race -Age (3-8 y/o) Bronchial mast cell degranulates -Histamine -Leukotrienes -Bradykinin

    -Serotonin Inflammatory Response Chemical Mediator released Effects: -Wheezing -Breathlessness -Chest Tightness -Coughing Mucus production Mucus clearance Water loss from mucus Altered CO2-O2 exchange Smooth muscle contraction and Hypertrophy Bronchospasm Impaired mucociliary tien Airway Obstruction Sign and Symptoms: Audible expiratory & inspiratory respiration Nasal Flaring Dyspnea Tachycardia Good Prognosis: Bronchodilators Relaxes smooth muscle Increase Airway passage Precipitating Factor: -Allergic to dust -Stress -Lifestyle

    Bad Prognosis: Severe Bronchospasm Complete Airway Blockage Status Asthmaticus May lead to death without immediate intervention

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