Integrins : Receptors that mediate attachment of cells to cells n tissues n extracellular matrix , play role in cell signaling ,define

cell shape n mobility Squamous cell CA: Below jaw line Basal cell CA : Above the jaw line Felty syndrome : Polyarticular RA Splenomegaly , leg ulcers ,leukopenia , associated with RA and SLE Still disease : Age <16 yrs ,spiking fever , joint swelling , lymphadenopathy , hepatosplenomegaly , neutrophilic leukocytosis, RA factor negative Ortner's syndrome : Enlarged left atrium ,compress Lt recurrent laryngeal nerve --> hoarseness Etanercept : Adverse effect : hypersensitivity , fungal n bacterial infections Vimen --> connective tissue Desmin --> skeletal muscle Molluscum contagiosum : Pox virus causes eosinophilic cytoplasmic inclusion . They are dome shape umblicated Papules . Hyperkalemic periodic paralysis : Paroxysm of muscle paralysis and weakness , autosomal dominant , triggered by large CHO meals n stress Lab finding : decrease potassium

Musculoskeletal MYoSiTiS Ossificans : Common in athletics , young adults , following trauma X ray : resembles extraskeletal oseosarcoma. Absence of contraction in muscle : Abnormality of troponin c or myosin

Sciatic nerve injury : Difficulty in extending thigh n flexing knee Blood supply of head of femur : Sup and inferior gluteal artery ,medial n lateral circumflex artery Dorsalis pedis artery --> lies btw extersor digitorum longus n extensor hallacis longus Legg calves perthens disease ; Avascular necrosis if head of femur Sjgrens syndrome : Joint aspirate :proliferative synovitis with lymphocytes , macrophages and plasma cells Rheumatoid arthritis : Synovial fluid :lympho , plasma cells Late stage : langerhens cells Fibromyalgia : Muscle pain , emotional disturbance , insomnia Sarcoidosis : Cd4 cell react with antigen --> increase cytokines --> non caseating granuloma Limb girdle muscle dystrophy : extracelluar matrix molecule ( proteoglycan ) disorder Sprain ankle : Anterior talo Fibular ligament ( lateral injury )