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  • Reactions of Drug Metabolism

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    Katalina Rosales
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    Drug metabolism involves two phases of reactions in the body. Phase I reactions involve modifying the drug through oxidation, reduction, or hydrolysis reactions catalyzed by cytochrome P450 enzymes in the liver. Phase II reactions then conjugate the drug or drug metabolites with endogenous substrates like glucuronic acid, sulfate, or glutathione, which facilitates the elimination of the now water-soluble compound. Together, these two phases of drug metabolism make the drug more polar and water-soluble so that it can be readily excreted from the body in urine or bile.

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    Phase I and Phase II Reactions

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    Drug metabolism involves two phases of reactions in the body. Phase I reactions involve modifying the drug through oxidation, reduction, or hydrolysis reactions catalyzed by cytochrome P450 enzymes in the liver. Phase II reactions then conjugate the drug or drug metabolites with endogenous substrates like glucuronic acid, sulfate, or glutathione, which facilitates the elimination of the now water-soluble compound. Together, these two phases of drug metabolism make the drug more polar and water-soluble so that it can be readily excreted from the body in urine or bile.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
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    6 views1 page

    Reactions of Drug Metabolism

    Uploaded by

    Katalina Rosales
    Drug metabolism involves two phases of reactions in the body. Phase I reactions involve modifying the drug through oxidation, reduction, or hydrolysis reactions catalyzed by cytochrome P450 enzymes in the liver. Phase II reactions then conjugate the drug or drug metabolites with endogenous substrates like glucuronic acid, sulfate, or glutathione, which facilitates the elimination of the now water-soluble compound. Together, these two phases of drug metabolism make the drug more polar and water-soluble so that it can be readily excreted from the body in urine or bile.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
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    Reactions of drug metabolism

    Phase I and Phase II Reactions

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