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  • Phenothiazine S

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    Aprilini Fitrisia
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    Phenothiazines are anti-psychotic drugs used to treat schizophrenia, manic depression, and idiopathic psychoses. They have a tricyclic chemical structure consisting of two benzene rings connected by a sulfur and nitrogen containing ring. Substitutions on the 2 and 10 positions can alter their efficacy and pharmacological effects. Phenothiazines work as neuroleptics by blocking dopamine D1 and D2 receptors, especially D2 receptors. They are used to treat schizophrenia by reducing hyperactivity of dopamine in the mesolimbic pathway of the brain. Common side effects include seizures, agranulocytosis, cardiac toxicity, and retinal degeneration.

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    antidepresan

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    Phenothiazine s

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    Phenothiazines are anti-psychotic drugs used to treat schizophrenia, manic depression, and idiopathic psychoses. They have a tricyclic chemical structure consisting of two benzene rings connected by a sulfur and nitrogen containing ring. Substitutions on the 2 and 10 positions can alter their efficacy and pharmacological effects. Phenothiazines work as neuroleptics by blocking dopamine D1 and D2 receptors, especially D2 receptors. They are used to treat schizophrenia by reducing hyperactivity of dopamine in the mesolimbic pathway of the brain. Common side effects include seizures, agranulocytosis, cardiac toxicity, and retinal degeneration.

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    38 views4 pages

    Phenothiazine S

    Uploaded by

    Aprilini Fitrisia
    Phenothiazines are anti-psychotic drugs used to treat schizophrenia, manic depression, and idiopathic psychoses. They have a tricyclic chemical structure consisting of two benzene rings connected by a sulfur and nitrogen containing ring. Substitutions on the 2 and 10 positions can alter their efficacy and pharmacological effects. Phenothiazines work as neuroleptics by blocking dopamine D1 and D2 receptors, especially D2 receptors. They are used to treat schizophrenia by reducing hyperactivity of dopamine in the mesolimbic pathway of the brain. Common side effects include seizures, agranulocytosis, cardiac toxicity, and retinal degeneration.

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    PHENOTHIAZINES (Fenotiazin)

    Anti psikotik Terapi Schizophrenia, manic depressive, idiophatic psychotic Struktur : mempunyai 3 struktur cincin (2 cincin benzen dihubungkan o/ cincin dg atom sulfur dan nitrogen) Trisiklik anti psikotik lain: Thioxanthene Substitusi pd posisi 2 dan 10 akan merubah efikasi dan mempengaruhi efek farmakologinya. Tabel Cth. Promazine, Chlorpromazine,

    Farmakologi Anti psikotik


    Neuroleptik Chlorpromazine dan Haloperidol adl cth senyawa neuroleptik pertama. Efek sedatif Efek pd pola tidur tdk konsisten, tp biasanya menormalkan gangguan tidur. Side Effect : seizures, agranulocytosis, cardiac toxicity, degenerasi pigmen retina. Side effect pd saraf: Dystonia akut, akathisia, parkinsonisme, neuroleptik malignant syndrom, perioral tremor,

    Reseptor Fenotiazin
    Reseptor dopamin D1 dan D2, meskipun D2 lebih kuat. merupakan reseptor metabotropik Skizoprenia : gangguan kejiwaan, halusinasi, delusi, pikiran yg tdk terorganisir, yg disebabkan krn hiperaktifitas dopamin pd jalur mesolimbik di otak.

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