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ET


1999

T HA

IS
TROKE SOCI

Clinical Practice Guidelines for Hemorrhagic Stroke

Clinical Practice Guidelines for Hemorrhagic Stroke

T HA

ET
Y

1999

IS
TROKE SOCI

(Clinical Practice Guidelines for Hemorrhagic Stroke)

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ISBN

: 978974422702-7

1 : 2556
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..
.

:



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9 64 14 10310
. 0-2530-4114 () 0-2108-8950-51
E-mail : tanapress@gmail.com, tana@tanapress.com

8/15/13 1:21:05 PM


Stroke




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(i)

(ii)

(iii)

(iv)

(vi)

(vii)

1
1
3

(Guidelines for the Management of Hemorrhagic Stroke)


2
8

(Surgical Management of Hemorrhagic Stroke)


3
21
(Medical Management in Acute Phase of Hemorrhagic Stroke)
4
22
(Guidelines for the Rehabilitation of Hemorrhagic Stroke)



1. (Calculation of of Hematoma volume)
34
2
35
3. CT scan of Normal Brain
37
4. Hydrocephalus CT Brain (Diagnosis of Hydrocephalus by CT brain)
39
5. CT brain of Hemorrhagic Stroke
40
6. (Factors affect outcome)
44
7. CT scan
46
(Risk of hematoma expansion after initial CT Scan)
8. (case study)
47


53

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1

2

3

4

5

6

7

8

9


vi
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(Initial management and Diagnosis of stroke)

(Classification of Hemorrhagic Stroke by Location)
Lobar Hemorrhage
(Management of Lobar Hemorrhage)
Basal Ganglia
(Management of Basal Ganglia Hemorrhage)
Thalamus
(Management of Thalamic Hemorrhage)

(Management of Cerebellar Hemorrhage)
brainstem
(Management of Brainstem Hemorrhage)
Subarachnoid Space
(Management of Subarachnoid Hemorrhage)


4
6

12
14
16
17
19
23

(Clinical Practice Guidelines for Hemorrhagic Stroke)

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1 (Strength of Recommendation)
2 (Quality of Evidence: QE)
3 (Strength of recommendation)

(Strength of Recommendation)
4

(Medical Management in Acute Phase of Hemorrhagic Stroke)
5

(Treatment of Increased Intracranial Pressure)
6

(Guidelines for Neurosurgical Consultation in Hemorrhagic Stroke)




(Clinical Practice Guidelines for Hemorrhagic Stroke)

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26
28
29
30
31
32
33

vii
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1

2
3
4

5
6
7
8






viii
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(Calculation of Volume of Hematoma)

CT Scan of Normal Brain
Hydrocephalus CT Brain
(Diagnosis of Hydrocephalus by CT brain)
CT Brain of Hemorrhagic Stroke
(Factors affect outcome)
(Risk of hematoma expansion after initial CT Scan)
(Case study)


34
35
37
39
40
44
46
47

(Clinical Practice Guidelines for Hemorrhagic Stroke)

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(stroke, cerebrovascular disease)
1 ..2553
(Public Health Statistics A.D.2010)2 3

(20.6 )


1 2
(Disability Adjusted Life Year) 2 3



Stroke means rapidly developed clinical signs of focal (global) disturbance of cerebral
function lasting more than 24 hours or leading to death, with no apparent cause other than a
vascular origin.4


5




2551

- CT brain (computerized tomography brain)
CT scan
Siriraj Stroke Score

- Cerebellar hemorrhage


- Subarachnoid hemorrhage

-

-

-


-

(Clinical Practice Guidelines for Hemorrhagic Stroke)

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(Quality of Evidence: QE) 2 A, B, C I,II,III IV
(strength of recommendation) 5 ++, +, +/-, - --

( 1 - 3)

3

1.

2.

3.

4.


2
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(Guidelines for the management of hemorrhagic stroke)


(hemorrhagic stroke)
10-15 35-52 30 6,7

1 508
2553 39,948

63 100,000 9
10

11,12

24 23-38 13


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(Initial management and Diagnosis of stroke)



Sudden onset of neurological deficit with suspicious of stroke

Clinical assessment & grading*


Advanced life support & emergency lab.

CT Brain non contrast


No**


Normal/Hypodensity

CT brain scan


Hyperdensity/Mass


Ischemic
stroke/Others


Yes


Hemorrhagic
Stroke

* (GCS < 8, signs of brain herniation, hypoxia,

) advanced life support



** 3, 5

4
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sudden neurological deficit vital signs,
neurological signs emergency advanced life support airway,
ventilation Glasgow Coma Scale (GCS) score < 8
aspiration emergency laboratory tests

(CBC, BS, BUN, Cr, electrolytes)


anticoagulants
(extracranial cause)

Sudden onset of persistent focal neurological deficit and no history of head trauma
probability of stroke 80%14

acute stroke CT brain 15 ischemic
hemorrhagic stroke


(systolic blood pressure) 220 .. 170 ../. (
) anticoagulant antipaltlate warfarin aspirin

hemorrhagic stroke ischemic stroke16


ischemic hemorrhagic stroke CT brain



CT brain ischemic stroke
hemorrhagic stroke

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SAH & IVH*


SAH & ICH*


Primary IVH


IVH


ICH & IVH*

= Intracerebral hemorrhage
ICH
ICH

IVH
= Intraventricular hemorrhage
ICH & IVH

Lobar
= ICH in cortical or subcortical area
Primary SAH

Non-lobar = ICH in basal ganglia, thalamus, brain stem, cerebellum Primary IVH
SAH
= Subarachnoid hemorrhage
SAH & ICH

Primary IVH = IVH
SAH & IVH
* primary hemorrhage


Primary SAH


SAH


Hemorrhagic stroke


ICH

Lobar

3-7 ( 8,11,13,15,17)
3-7 ( 8,11,13,15,17)




3-7


Non-lobar

(Classification of Hemorrhagic Stroke by Location)


CT
brain CT brain
hemorrhagic stroke 3 subarachnoid hemorrhage (SAH),
intraventricular hemorrhage (IVH), intracerebral hemorrhage (ICH)

(Clinical Practice Guidelines for Hemorrhagic Stroke)

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(Surgical Management of Hemorrhagic Stroke)


/ arteriovenous malformation (AVM), aneurysm

8
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Lobar Hemorrhage
(Management of Lobar Hemorrhage)

HCP**

or

IVH with HCP

or

SAH

or

Temporal lobe
hematoma

Lobar hemorrhage

Criteria for neurosurgical consultation


1. GCS < 13
2. Volume of hematoma > 30 ml.
3. Midline shift > 0.5 cm.


Criteria > 2


Criteria < 2

Medical treatment


Worse*


Improved ( 9)

Lobar hemorrhage
1. CT brain abnormal vessels
2. < 45
3.

Discharge



= 0.524 X Y Z
(X,Y,Z = X,Y,Z )17


* (extracranial cause)

2

** 4

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GCS = Glasgow Coma Scale

HCP = Hydrocephalus

IVH = Intraventricular hemorrhage

SAH = Subarachnoid hemorrhage

Hematoma CT brain CT brain
24 onset15 ( 7)



Lobar hemorrhage intracerebral hemorrhage (ICH) cortical
subcortical frontal, temporal, parietal, occipital lobes
cerebral amyloid angiopathy, aneurysm, AVM
> 2 GCS < 1319,20, volume > 30 ml.21, midline shift > 0.5 cm.22
1
(medical treatment)
< 45 CT brain abnormal blood vessels

enlarged vessels calcification hematoma hyperdensity dura venous sinus


cortical vein venous drainage hematoma

cerebral angiography23 - 25

temporal lobe early brain herniation 21

10
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Non-Lobar Hemorrhage

(Management of Non-Lobar Hemorrhage)


Non-lobar hemorrhage intracerebral hemorrhage basal ganglia (
putamen), thalamus, cerebellum, brainstem ( pons)

stroke 45 hypertensive hemorrhage23,24

45 CT brain

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Basal Ganglia
(Management of Basal Ganglia Hemorrhage)

Basal ganglia hemorrhage*

Criteria for neurosurgical consultation


1. GCS < 13
2. Volume of hematoma > 30 ml.
3. Midline shift > 0.5 cm.

HCP***

or

IVH with HCP

or
SAH


Criteria > 2


Criteria < 2

Medical treatment


Worse*


Improved ( 9)

Discharge



= 0.524 X Y Z

(X,Y,Z = X,Y,Z )17

* Basal ganglia hemorrhage putamen, globus pallidus


caudate nucleus ( 5 40)

** 2

GCS = Glasgow Coma Scale HCP = Hydrocephalus

IVH = Intraventricular hemorrhage SAH = Subarachnoid hemorrhage

*** 4

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(Clinical Practice Guidelines for Hemorrhagic Stroke)

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Basal ganglia hemorrhage > 2 GCS < 13,

volume > 30 ml. 26, midline shift > 0.5 cm. 22 < 2

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Thalamus
(Management of Thalamic Hemorrhage)

HCP

or

IVH with HCP

Thalamic hemorrhage

Criteria for neurosurgical consultation


1. GCS < 13
2. Volume of hematoma > 10 ml.
3. Midline shift > 0.5 cm.


Criteria > 2


Criteria < 2

Medical treatment


Worse*


Improved ( 9)

Discharge


= 0.524 X Y Z

(X,Y,Z = X,Y,Z )12

* 2

GCS = Glasgow Coma Scale

HCP = Hydrocephalus

IVH = Intraventricular hemorrhage

** 4

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(Clinical Practice Guidelines for Hemorrhagic Stroke)

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Thalamic hemorrhage > 2 GCS < 13, volume > 10 ml.27,28,
midline shift > 0.5 cm. / hydrocephalus (HCP)
< 2 hydrocephalus

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(Management of Cerebellar Hemorrhage)


Cerebellar hemorrhage


* (refer case)

6

Cerebellar hemorrhage hemorrhagic stroke

hemorrhagic stroke
Cerebellar hemorrhage
hydrocephalus


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(Clinical Practice Guidelines for Hemorrhagic Stroke)

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brainstem
(Management of Brainstem Hemorrhage)

Criteria


Brainstem hemorrhage*
for neurosurgical consultation
1. GCS < 13
2. HCP ***
3. IVH with HCP


Criteria > 1


Criteria = 0

Medical treatment


Worse*


Improved ( 9)

Discharge



GCS = Glasgow Coma Scale

HCP = Hydrocephalus

IVH = Intraventricular hemorrhage

* signs brainstem dysfunction 2

** Repeated episodes Brainstem hemorrhage

*** 4

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7

Brainstem hemorrhage pons GCS < 13
hydrocephalus (HCP) intraventricular hemorrhage with HCP
(repeated episodes) cavernous
angioma GCS > 13
hydrocephalus

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(Clinical Practice Guidelines for Hemorrhagic Stroke)

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Subarachnoid Space
(Management of Subarachnoid Hemorrhage)

Clinical suspicion of SAH

CT brain non contrast


Other diagnosis


Negative for SAH


Positive
for SAH

+ ICH / IVH


LP for CSF analysis

Normal or Other diagnosis

(persistent RBC
SAH
+/- xanthochromia)


Appropriate management


CSF =

CT brain =

ICH =

IVH =

Cerebrospinal fluid LP = Lumbar puncture


Computer tomography brain RBC = Red blood cell
Intracerebral hemorrhage SAH = Subarachnoid hemorrhage
Intraventricular hemorrhage

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8
Subarachnoid hemorrhage (SAH) subarachnoid space

SAH ruptured aneurysm, ruptured AVM, blood dyscrasia,
head injury, parasite

SAH CT brain CT brain SAH
SAH parasite

SAH 2
CT brain

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(Clinical Practice Guidelines for Hemorrhagic Stroke)

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(Medical Management in Acute Phase of Hemorrhagic Stroke)
(Blood pressure management)

ICH
SAH 4
(Management of body temperature)

brain
metabolism 29 4
(Management of Blood Glucose)


stress 30
> 140 ./.
(Prevention of Seizure)

ICH (grade C)

(grade A)


isotonic solution normal saline
4
(Management of increased intracranial pressure)


pulse pressure
5

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(1)

(2)

(2)

2 (3)

1 (3)

2 .. (4)

1/2 .. (4)




(7)/


(8)


(5)


(6)

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9

(1) 31


48

(2)
2.1

- (motor function assessment)

- (sensory assessment)

- (coordination)

- (range of motion)

- (muscle tone)
2.2

-



-
2.3
2.4
2.5 (cognitive and perception assessment)
2.6 (Bowel and bladder function)
2.7
2.8

*

(3) 2


1




24

(4)

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(5) 31


2 3

(6)

1 2
2-3

(7)

7.1



7.2

7.3

7.4

7.5

(8)

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++

1.
(QE = I) 32 - 34
2.

++

2.1 (QE = III) 35

+/-

+/-

2.4 (resting or antispastic splint)


(QE = III)35

+/-

2.5 Diazepam
(QE = II-2)41

2.2


Tizanidine Baclofen


Tizanidine (QE = II-1)36

2.3 Botulinum toxin A (QE = I)37 - 40


phenol alcohol

3.
++

3.1

++

3.2

3.3

3.4 (overhead pulleys)42


4.

++

4.1

++

4.2

+/-

4.3 (QE = III-2)43

++

5.
(QE = III)44 - 46

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(Clinical Practice Guidelines for Hemorrhagic Stroke)

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- 38 C

- > 100 < 60 /

- SBP >180 < 90 DBP > 110 < 60

-

-

-

-

-

-

-

-

(Clinical Practice Guidelines for Hemorrhagic Stroke)

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1 (Strength of Recommendation)
Grade

Recommendation

supported by data from randomized controlled trials with low false-positive


and low false-negative errors

supported by data from randomized controlled trials with high false-positive


and high false-negative errors

supported by data from non-randomized cohort studies, case series,


case report, expert opinion or consensus

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2 (Quality of Evidence: QE)


I
I-1
I-2
II
II-1
II-2
II-3
II-4


(systemic review) -
(randomized-controlled clinical trials)
-
(a well-designed, randomized-controlled, clinical trial)

(non-randomized,
controlled, clinical trial)
(well-designed, non-randomized,
controlled clinical trial)
(cohort)
(case control analytic studies)
/
(multiple time series)


..

III
III-1
III-2


(descriptive studies)
(fair-designed, controlled clinical trial)

IV
IV-1

(consensus)

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3 (Strength of recommendation)
(Strength of Recommendation)

++


(cost effective) /
(strongly recommend)


/ (recommend)

+/-




(neither recommend nor against)


(against)

--


(strongly against)

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(Medical Management in Acute Phase of Hemorrhagic Stroke)


1. Respiration
blood gas

2. Blood Pressure6
hypotension
mean arterial pressure (MAP) < 110 mmHg BP 160/90
(grade C)
MAP = Diastolic BP + 1/3 (Systolic BP - Diastolic BP)
2.1 systolic BP > 200 mmHg MAP > 150 mmHg
- Nitroprusside 0.25-10 g/kg/min 3
- Nitroglycerine 5 mg 1-4 mg/hr
- 2.2
2.2 systolic BP = 180-200 mmHg DBP = 105-140 mmHg MAP > 130 mmHg
- Captopril 6.25-12.5 mg 15-30 4-6 ..
- Small patch of nitroglycerine
- Hydralazine 5-10 mg 1-2 1-2 ..
- Nicardepine 0.1-0.2 mg/ml 5 mg/hr.
- nifedipine

2.3 Systolic BP = 180-200 mmHg MAP > 130 mmHg

cerebral perfusion pressure 60 mmHg
3. Temperature
cooling blanket
4. (Management of Blood Glucose)
> 140 ./.
5. (Prevention of Seizure)

6. Fluid & Electrolyte*
- dehydration overhydration isotonic solution
normal saline = urine output + 500 ml (insensible
loss) 300 ml/1oC (37oC)
- electrolyte *

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(Treatment of Increased Intracranial Pressure)

1. Clear airway Foleys catheter


2. 20-30
3. (jugular vein)
4. Hyperventilation PaCO2 = 30-35 mmHg
5. *
- 20% mannitol : loading dose 1 gm/kg 20
0.25-0.5 gm/kg 6 serum osmolarity
serum osmolarity < 320 mOsm/l (grade C)
- 10% glycerol 250 ml 30 6
- 50% glycerol 50 ml 4
- Furosemide 1 mg/kg (grade C)
6. hypotonic solution
7. steroid 47,48 (grade A)

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(Guidelines for Neurosurgical Consultation in Hemorrhagic Stroke)

Lobar

Temporal lobe
Basal ganglia

Thalamus

Cerebellum
Pons

Subarachnoid
hemorrhage (SAH)
Primary intraventicular
hemorrhage (IVH)
Hydrocephalus (HC)

(criteria)
1. GCS < 13
2. Volume > 30 ml
3. Midline shift > 0.5 cm.
1. GCS < 13
2. Volume > 30 ml
3. Midline shift > 0.5 cm.
1. GCS < 13
2. Volume > 10 ml
3. Midline shift > 0.5 cm.
1. GCS < 13
2. HC
3. IVH
4. Repeated episodes
-

Criteria < 2

Criteria > 2

Criteria < 2

Criteria > 2

Criteria < 2

Criteria > 2

Criteria = 0

Criteria > 1

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(Calculation of Volume of Hematoma)17

(volume of hematoma) = 0.524 * X * Y * Z
(X, Y, Z X, Y, Z)










1. slice (slice thickness) .


1 . slice thickness = t
2. (hematoma) (location)
3. slice slices = n slices
4. Z = t * n c
5. slice slice
6. X = a Y = b
( a b )
7. (volume of hematoma) = 0.524 * a * b *c
(c = t * n)

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1. Vital signs:
a. Blood pressure (BP): Cushings reflex BP
Pulse pressure
b. Heart rate (HR): Cushings reflex HR
c. Respitatory rate (RR): (worse)
RR Apnea
2. Glasgow Coma Scale (GCS) : GCS score 2

3. Pupil:
a. Size: pupil Brain herniation (uncal herniation)
b. Equality: pupil 1 mm
c. Reaction to light: pupil Brain herniation (uncal
herniation)
pupil (
)
4. Motor power: motor power 1 grade

5. increased intracranial pressure hydrocephalus (vomiting, sixth


nerve palsy), brain herniation

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GCS (Glasglow Coma Scale)


Level of response

Scale value
1. Eye opening
Spontaneously
4
To speech
3
To pain
2
None
1
2. Motor response
Obeys commands
6
Localizes to pain
5
Withdraws to pain
4
Abnormal flexion
3
Abnormal extension
2
None
1
3. Verbal response
Oriented
5
Confused
4
Inappropriate words
3
Incomprehensible
2
None
1
Brainstem dysfunction
Hemorrhagic stroke Brainstem dysfunction
1 Vital signs: RR
2. Level of consciousness: Brainstem Reticular activating system

3. Brainstem
a. Brainstem function: Cranial nerve (CN. III, IV, VI)
(CN. VII) (CN.IX, X)
b. Brainstem reflexes: Corneals reflex (CN. V & VII), Dolls eye (CN. III & VI & VIII),
Caloric test (CN.III & VI & VIII), Nystagmus (CN.III & VI & VIII), Gag reflex (CN.IX)

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CT Scan of Normal Brain62

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Hydrocephalus CT Brain
(Diagnosis of Hydrocephalus by CT brain)
Hydrocephalus was defined as the presence of
1. The presence of a dilated contralateral temporal horn.
2. Unilateral dilated frontal and posterior horn of the lateral ventricle from deep cerebral
hemorrhage.
3. Bilateral dilated lateral ventricles with or without a dilated third ventricle resulting from
obstruction by a clot in the ventricle or the mass effect of deep cerebral hemorrhage.
4. The frontal horn is considered to have enlarged if there is an increased radius, decreased
ventricular angle, and sulcal effacement of the frontal lobe.
5. The posterior horn is considered to have enlarged if there is rounding of the posterior horn
with sulcal effacement of the parieto-occipital lobe.
6. The third ventricle is enlarged if the width is increased (> 7 mm.) and if there is ballooning
of the anterior recess.
7. The fourth ventricle is considered enlarged if there is bulging.
8. The bicaudate index : > 0.15 = ventricular enlargement
9. Evans ratio (index)is the ratio of maximum with of the frontal horns to the maximum with
of the inner table of the cranium = A/B > 0.3 in hydrocephalus

Hydrocephalus by CT brain A and B : Evans ratio = 0.34



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CT Brain of Hemorrhagic Stroke


Lobar hemorrhage

3
Frontal lobe

4
Temporal lobe

5
Parieto-occipital lobe

Basal ganglia hemorrhage

6
Small hemorrhage
at putamen

7
8
Classical hemorrhage Large basal ganglia hemorrhage
at globus pallidus
with secondary IVH

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Thalamic hemorrhage

9
Small thalamic hemorrhage

10
Large thalamic hemorrhage
with secondary IVH

11
Cerebellar hemorrhage

12
Small pontine hemorrhage

13
Large Pontine hemorrhage

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14
Diffuse subarachnoid hemorrhage

15
Intraventricular hemorrhage in bilateral
ventricles and small amount of subarachnoid
hemorrhage along bilateral sylvian fissures

16
Intraventricular hemorrhage
in the 3rd ventricle and lateral ventricle

17
Intraventricular hemorrhage
in the 4th ventricle

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18 Rupture anterior communicating artery aneurysm (not shown)


with subarachnoid hemorrhage at the inferior anterior interhemispheric fissure

19 Rupture right middle cerebral artery aneurysm (not shown)


with diffuse subarachnoid hemorrhage and a localized hematoma
at the lateral right sylvian fissure

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(Factors affect outcome)



1. GCS score/stroke score
2. Location of hematoma
3. Size of hematoma
4. Coagulopathy
5. Hydrocephalus
Prospective Castellanos et al. 49
higher Canadian stroke score; lower blood pressure; higher
fibrinogen concentrations, CT findings smaller volume of ICH; more peripheral location of
hematoma; less intraventricular spread of bleeding; less midline shift.
prognosis & outcome

Intracerebral Hemorrhage (ICH) Score =


ICH score
Glasgow Coma Score*

3-4
5-12
13-15
(, cc.)**
>30
<30

tentorium

()
>80
<80
*Glasgow Coma Scale
** (A X B X C) / 2

2
1
0
1
0
1
0
1
0
1
0

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Intracerebral Hemorrhage
50
Glasgow coma score, 80 , ,
(intraventricular extension) tentorium
cerebellum (infra-or supra-tentorial location) ICH score
51 A x B x C / 2
A B C
slides 3 ICH score
52 - 54 ICH score functional
outcomes 1 7 55
Spot sign CT angiogram 24
spot sign score
spot sign score 54
spot sign score 9
1 45% 51% 51, 57- 59
meta-analysis 1 40.4%
1980 2008 60 2 56%
61%58 2.7% 16% 1 61

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(Risk of hematoma expansion after initial CT Scan)
The cutpoint for hematoma enlargement was determined as
V2-V1 = 12.5 cm3 or V2/V1 = 1.4 (sensitivity = 94.4%, specificity = 95.8%).
Kazui et al18 CT scan
Initial CT scan at 3 hours after onset of stroke 36%
Initial CT scan at 3 to 6 hours after onset of stroke 16%
Initial CT scan at 6 to 12 hours after onset of stroke 15%
Initial CT scan at 12 to 24 hours after onset of stroke 6%
Initial CT scan at 24 to 48 hours after onset of stroke 0%
( V1 = initial CT scan, V2 = second CT scan)

CT scan brian hematoma expansion

CT scan
alcoholic abuse; an irregularly shaped hematoma, and a low level of fibrinogen.50

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(Case study)
Case 1

- 41 .
- 8 ..

- BP 160/90 PR 80/min Temp 36.4 RR 17/min Blood Sugar 87 mg/dl PT, PTT normal
- GCS = 10, right hemiplegia
CT brain (at 8 hrs after onset):
- left putaminal hemorrhage, 3*4.3*2.1 cm., midline shift 3.3 mm.

Dx Left putaminal hemorrhage


Management
1. Volume of hematoma = 3*4.3*2.1*0.524 = 14.19 cc.
2. basal ganglia hemorrhage CPG criteria 1
(GCS = 10)
medical Rx
3. BP 160/90 mmHg criteria anti-hypertensive
conservative & supportive Rx

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4. CT brain 8 . onset expanding hematoma


15% observe ( 7) refer

5. Dx, management, risk

Case 2

- 71 . .
- 8 .

-
- 9 thalamus

- BP 200/100 mmHG PR 80/min Temp 37.4 RR 16/min


- GCS = 14, pupil 3 mm. RTL.BE., dysarthia, Gag reflex present, No facial palsy,
No nystagmus, Finger - Nose - Finger test impaired right side
- Left hemiparesis
CT brain (at 8 hrs after onset) :
- Right cerebellar hemorrhage 2.2*2.6*2.5 cm. with mild surrounding edema and mild
pressure effect upon fourth ventricle

Dx Right cerebellar hemorrhage


Management
1. Volume of hematoma = 2.2*2.6*2.5*0.524 = 7.49 cc.

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2. cerebellar hemorrhage CPG


3. BP 200/100 mmHg criteria anti-hypertensive
conservative & supportive Px
4. Dx, management, risk

Case 3

- 58 .
- 8 .
: DM, HT

- BP 140/90 mmHg PR 80/min Temp 37.2 RR 18/min


- GCS = 14, pupils 3 mm. RTL.BE., No facial palsy
- Right hemiparesis gr. III
CT brain (at 8 hrs. after onset) :
- Left thalamic hemorrhage 2.1*1.0*0.5 cm.

Dx Left thalamic hemorrhage without midline shift or hydrocephalus.


Management
1. Volume of hematoma = 2.1*1.0*0.5*0.524 = 0.55 cc.
2. thalamic hemorrhage CPG criteria 1
(GCS = 10 )
medical Px
3. BP 140/90 mmHg criteria anti-hypertensive
conservative & supportive Px

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4. CT brain 8 . onset expanding hematoma 15%


observe ( 7) refer

5. Dx, management, risk

Case 4

- 74
- 3 .

- Hyperthyroidism hypothyroidism
- Bradycardia, Heart AF
BP 170/100 mm.Hg PR 80/min Temp 36.8 RR 15/min.
- GCS = 9, Left hemiparesis Grade I
- Pupils Rt. 3 mm. RTL, Lt. 2 mm. sluggish RTL.
CT brain (3 hrs. after onset): right basal ganglia hematoma size = 6.9*4.6*7.0 cm. effacement of
right ventricle

Dx Lobar hemorrhage at right temporal lobe


Management
1. Volume of hematoma = 6.9*4.7*7.0*0.524 = 118.95 cc.
2. BP 170/100 mmHg criteria anti-hypertensive
3. lobar hemorrhage CPG criteria 2 (GCS = 9,
volume > 30 cc.
4. Dx, management, risk

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Case 5

- 72 .
- 2
: Old CVD, HT, Aspirin
: BP 140/ 90 mm.Hg PR 98/min Temp 36.8 RR 15/min.
- GCS = 15, pupils 3 mm. RTL. BE.
- Left hemianopia
CT brain (48 hrs. after onset) : right occipital lobe hematoma, size = 1.7*2.8*3.0 cm.

Dx - Lobar hemorrhage right occipital lobe


Management
1. Volume of hematoma = 1.7*2.8*3.0*0.524 = 7.48 cc.
2. lobar hemorrhage CPG criteria 0
medical Rx
3. BP 140/90 mmHg criteria anti-hypertensive
conservative & supportive Rx
4. CT brain 48 . onset expanding hematoma
( 7)
5. Dx, management, risk

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Case 6

- 44 .
- 3
: 8 1 20
: BP 138/77 mmHg PR 90/min Temp 36 RR 15/min.
- GCS = 15 pupils 2 mm. RTL., no weakness
CT brain (72 hrs. after onset) : Left parietal lobe hematoma, size = 3.0*1.3*2.1 cm.
Dx. Lobar hemorrhage at left parietal lobe
Management
1. Volume of hematoma = 3.0*1.3*2.1*0.524 = 4.29 cc.
2. lobar hemorrhage CPG criteria 0
medical Rx
3. BP 138/77 mmHg criteria anti-hypertensive conservative &
supportive Rx
4. CT brain 72 . onset expanding hematoma
( 7)
5. Dx, management, risk
6. 45
intracranial vascular study vascular abnormality

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1.
2.
3.

4.


5.

6.






7.

8.

9.

10.

11.

12.

The internet stroke center. www. Strokecenter.org.th. stroke statistics.


www.bps.ops.moph.go.th/healthinformation.
Ministry of public health. Burden of disease and injuries in Thailand Priority setting for policy.
2002; A14-16,58.
World Health Organization Meeting on Community Control of Stroke and Hypertension.
Control of stroke in the community: methodological considerations and protocol of WHO
stroke register. CVD/s/73.6 Geneva: WHO,1973.
. Technology assessment. : , .
. :, 2546:5.
Broderick J, Connolly S, Feldmann E, et al. American Heart Association; American Stroke
Association Stroke Council High Blood Pressure Research Council; Quality of Care and
Outcomes in Research Interdisciplinary Working Group. Guidelines for the management of
spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from theAmerican
Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research
Council, and the Quality of Care and Outcomes in Research InterdisciplinaryWorking Group.
Stroke 2007;38:200123
Kissela B, Schneider A, Kleindorfer D, et al. Stroke in a biracial population: the excess burdenof
stroke among blacks. Stroke 2004;35:42631.
Flaherty ML, Haverbusch M, Sekar P, et al. Long-term mortality after intracerebral hemorrhage.
Neurology 2006;66:1182-6.
,
, 2553
Qureshi AI, Tuhrim S, Broderick JP, et al. Spontaneous intracerebral hemorrhage. N Eng J Med
2001;344:1450-60
Davis SM, Broderick J, Hennerici M, et al. Hematoma growth is a determinant of mortality and
poor outcome after intracerebral hemorrhage. Neurology. 2006;66:1175-81.
Tuhrim S, Horowitz DR, Sacher M, et al. Volume of ventricular blood is an important
determinant of outcome in supratentorial intracerebral hemorrhage. Crit Care Med.
1999;27:617-21.

(Clinical Practice Guidelines for Hemorrhagic Stroke)

_13-0689(001)P3.indd 53

53
8/15/13 1:22:02 PM

13.

14.

15.

16.

17.

18.

19.

20.

21.

22.


23.


24.

25.


26.

Thorsten S, Julian B. Options to restrict hematoma expansion after spontaneous


intracerebral hemorrhage. Stroke. 2010;41:402-9.
Von Arbin M, Britton M, De Faire U, Helmers C, Miah K, Murray V. Validation of admission
criteria to a stroke unit. J Chronic Dis. 1980;33:215-220.
Broderick JP, Adams HP, Barsan W, Feinberg W, Feldmann E, Grotta J, et al. Guidelines for the
management of spontaneous intracerebral hemorrhage. Stroke 1999;30:905-15.
Panzer RJ, Feibel JH, Barker WH, Griner PF. Predicting the likelihood of hemorrhage in patients
with stroke. Arch Intern Med. 1985;145:1800-1803.
Broderick JP, Brott TG, Duldner JE, Tomsick T, Huster G. Volume of intracerebral hemorrhage,
a powerful and easy-to-use predictor of 30-day mortality. Stroke 1993; 24: 987-93.
Kazui S, Naritomi H, Yamamoto H, Sawada T, Yamaguchi T. Enlargement of Spontaneous
Intracerebral Hemorrhage. Stroke. 1996;27:1783-1787
Flemming KD, Wijdicks EF, Li H. Can we predict poor outcome at presentation in patients
with lobar hemorrhage? Cerebrovasc Dis 2001; 11: 183-9.
Flemming KD, Wijdicks EF, St Louis EK, Li H. Predicting deterioration in patients with lobar
haemorrhages. J Neurol Neurosurg Psychiatry 1999; 66: 600-5.
Andrews BT, Chiles BW 3rd, Olsen WL, Pitts LH. The effect of intracerebral hematoma location
on the risk of brain-stem compression and on clinical outcome. J Neurosurg 1988; 69: 518-22.
Sakas DE, Singounas EG, Karvounis PC. Spontaneous intracerebral haematomas: surgical
versus conservative treatment based on Glascow Coma Scale score and computer
tomography data. J Neurosurg Sci 1989; 33: 165-72.
Zhu XL, Chan MS, Poon WS. Spontaneous intracranial hemorrhage: which patients need
diagnostic cerebral angiography? A prospective study of 206 cases and review of the
literature. Stroke 1997; 28: 1406-9.
Loes DJ, Smoker WR, Biller J, Cornell SH. Nontraumatic lobar intracerebral hemorrhage:
CT/angiographic correlation. Am J Neuroradiol 1987; 8: 1027-30.
Halpin SF, Britton JA, Clifton A, Hart G, Moore A. Prospective evaluation of cerebral angiography
and computered tomography in cerebral hematoma. J Neurol Neurosurg Psychiatry 1994;
57: 1180-6.
Kaya RA, Turkmenoglu O, Ziyal IM, Dalkilic T, Sahin Y, Aydin Y. The effects on prognosis of
surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular
approach. Surg Neurol 2003; 59: 176-83.

54
_13-0689(001)P3.indd 54

(Clinical Practice Guidelines for Hemorrhagic Stroke)

8/15/13 1:22:02 PM

27.


28.

29.

30.


31.


32.

33.


34.


35.


36.


37.


38.

Sasaki K, Matsumoto K. Clinical appraisal of stereotactic hematoma aspiration surgery for


hypertensive thalamic hemorrhage--with respect to volume of the hematoma. Tokushima
J Exp Med 1992; 39: 35-44.
Kwak R, Kadoya S, Suzuki T. Factors affecting the prognosis in thalamic hemorrhage. Stroke
1983; 14: 493-500.
Azzimondi G, Bassein L, Nonino F, Fiorani L, Vignatelli L, Re G, DAlessandro R.Fever
in acute stroke worsens prognosis. A prospective study.Stroke. 1995 Nov;26(11):2040-3.
Fogelholm R, Murros K, Rissanen A, Avikainen S. Admission blood glucose and short term
survival in primary intracerebral hemorrhage: a population base study. J Neurol Neurosurg
Psychiatry. 2005; 76: 349-353.
Gresham GE, Duncan PW, Stason WB et al. Clinical practice guideline. Number 16,
Post-stroke rehabilitation. U.S. Department of Health and Human Services Public
Health Service Agency for Health Care Policy and Research (AHCPR) Publication 1995.
Maulden SA, Gassaway J, Horn SD, Smout RJ, DeJong G. Timing of Initiation of Rehabilitation
after Stroke. Arch Phys Med Rehabil 2005; 86: S34-40.
Musicco M, Emberti L, Nappi G, Caltagirone C. Early and Long-Term Outcome of
Rehabilitation in Stroke Patients: The Role of Patient Characteristics, Time of Initiation, and
Duration of Interventions. Arch Phys Med Rehabil 2003; 84: 551-8.
Paolucci S, Antonucci G, Grasso MG et al. Early versus delayed inpatient stroke
rehabilitation: a matched -comparison conducted in Italy. Arch Phys Med Rehabil 2000; 81:
695-700.
RCP, 2000 - Royal College of Physicians. National Clinical Guidelines for Stroke.
Available on URL: http://www.rcplondon.ac.ak/pubs/books/stroke/ceeu_stroke_service02.
htm 2000
Gelber DA, Good DC, Dromerick A, Sergay S, Richardson M. Open-label dose-titration safety
and efficacy study of tizanidine hydrochloride in the treatment of spasticity associated with
chronic stroke. Stroke 2001; 32: 1841-6.
Francis HP, Wade DT, Turner-Stokes L, Kingswell RS, Dott CS, Coxon EA. Does reducing
spasticity translate into functional benefit? An exploratory meta-analysis. J Neurol
Neurosurg Psychiatry 2004; 75: 1547-51.
Bhakta BB, OConnor RJ, Cozens JA. Associated reactions after stroke: a randomized
controlled trial of the effect of botulinum toxin type A. J Rehabil Med 2008; 40: 36-41.

(Clinical Practice Guidelines for Hemorrhagic Stroke)

_13-0689(001)P3.indd 55

55
8/15/13 1:22:02 PM

39.

40.



41.


42.

43.


44.

45.

46.

47.


48.

49.



50.

Brashear A, Gordon MF, Elovic E et al. Intramuscular injection of botulinum toxin for
the treatment of wrist and finger spasticity after a stroke. N Engl J Med 2002; 347: 395-400.
Childers MK, Brashear A, Jozefczyk P, Reding M, Alexander D, Good D, Walcott JM,
Jenkins SW, Turkel C, Molloy PT. Dose-dependent response to intramuscular botulinum toxin
type A for upper-limb spasticity in patients after a stroke. Arch Phys Med Rehabil 2004; 85:
1063-9.
Troisi E, Paolucci S, Silvestrini M, Matteis M, Vernieri F, Grasso MG, et al. Prognostic factors in
stroke rehabilitation: the possible role of pharmacological treatment. Acta Neurol Scand.
2002; 105: 100-6.
Kumar R, Metter EJ, Mehta AJ, Chew T. Shoulder pain in hemiplegia. The role of exercise.
Am J Phys Med Rehabil. 1990; 69: 205-8.
Ada L, Foongchomcheay A. Canning C. Supportive devices for preventing and treating
subluxation of the shoulder after stroke. The Cochrane Database of Systematic Reviews
2005.
Brereton L, Carroll C, Barnston S. Interventions for adult family carers of people
who had a stroke: a systematic review. Clin Rehabil. 2007; 21: 867-84.
Lee J, Soeken K, Picot SJ. A meta-analysis of interventions for informal stroke caregivers.
West J Nurs Res. 2007; 29: 344-56.
Smith J, Forster A, House A, Knapp P, Wright J, Young J. Information provision for
stroke patients and their caregivers. The Cochrane Database of Systematic Reviews 2008.
Poungvarin N, Bhoopat W, Viriyavejakul A, Rodprasert P, Buranasiri P, Sukondhabhant S,
et al. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl
J Med 1987; 316: 1229-33.
De Reuck J, De Bleecker J, Reyntjens K. Steroid treatment in primary intracerebral
haemorrhage. Acta Neurol Belg 1989; 89: 7-11.
Castellanos M, Leira R, Tejada J, Gil-Peralta A, Davalos A, Castillo J : Stroke Project,
Cerebrovascular Diseases Group of the Spanish Neurological Society. Predictors of good
outcome in medium to large spontaneous supratentorial intracerebral hemorrhage.
J Neurol Neurosurg Psychiatry. 2005;76:691-695.
Shaya M, Dubey A, Berk C, et al. Factors influencing outcome in intracerebral hematoma:
a simple, reliable, and accurate method to grade intracerebral hemorrhage. Surgical
Neurology 2005;63:343-8.

56
_13-0689(001)P3.indd 56

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8/15/13 1:22:03 PM

51.

52.


53.

54.

55.

56.


57.


58.

59.

60.


61.

62.

Hemphill JC, 3rd, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH
score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke 2001;32:891-7.
Jamora RD, Kishi-Generao EM, Jr., Bitanga ES, Gan RN, Apaga NE, San Jose MC. The ICH score:
predicting mortality and functional outcome in an Asian population. Stroke 2003;34:6-7;
author reply 6-7.
Godoy DA, Boccio A. ICH score in a rural village in the Republic of Argentina. Stroke 2003;
34:e150-1; author reply e-1.
Fernandes H, Gregson BA, Siddique MS, Mendelow AD. Testing the ICH score. Stroke 2002;
33:1455-6; author reply -6.
Hemphill JC, 3rd, Farrant M, Neill TA, Jr. Prospective validation of the ICH Score for
12-month functional outcome. Neurology 2009;73:1088-94.
Delgado Almandoz JE, Yoo AJ, Stone MJ, et al. Systematic characterization of the
computed tomography angiography spot sign in primary intracerebral hemorrhage identifies
patients at highest risk for hematoma expansion: the spot sign score. Stroke 2009;40:2994-3000.
Lisk DR, Pasteur W, Rhoades H, Putnam RD, Grotta JC. Early presentation of hemispheric
intracerebral hemorrhage: prediction of outcome and guidelines for treatment
allocation. Neurology 1994;44:133-9.
Shah QA, Ezzeddine MA, Qureshi AI. Acute hypertension in intracerebral hemorrhage:
pathophysiology and treatment. J Neurol Sci 2007;261:74-9.
Juvela S. Risk factors for impaired outcome after spontaneous intracerebral hemorrhage.
Arch Neurol 1995;52:1193-200.
van Asch CJ, Luitse MJ, Rinkel GJ, van der Tweel I, Algra A, Klijn CJ. Incidence, case
fatality, and functional outcome of intracerebral haemorrhage over time, according to
age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol;9:167-76.
Maruishi M, Shima T, Okada Y, Nishida M, Yamane K, Okita S. Clinical findings in
patients with recurrent in tracerebral hemorrhage. Surgical Neurology 1995;44:444-9.
A from Alfidi, RJ, et al.: Computed tomography of the human body: An atlas of normal
anatomy, St. Louis, 1977, The C.V. Mosby Co.

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/
23 - 24 2555

1 .









2
3
4
5
6
7
8
9
10

.
.
.
.
..
..
.

.

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T HA

ET
Y

1999

IS
TROKE SOCI

ET
Y


1999

T HA

IS
TROKE SOCI

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Clinical Practice Guidelines for Hemorrhagic Stroke

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