Professional Documents
Culture Documents
1999
T HA
IS
TROKE SOCI
T HA
ET
Y
1999
IS
TROKE SOCI
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ISBN
: 978974422702-7
1 : 2556
: .
..
.
:
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9 64 14 10310
. 0-2530-4114 () 0-2108-8950-51
E-mail : tanapress@gmail.com, tana@tanapress.com
8/15/13 1:21:05 PM
Stroke
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14 2555 28 2555 12 2555
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3. / ()
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(i)
(ii)
(iii)
(iv)
(vi)
(vii)
1
1
3
1. (Calculation of of Hematoma volume)
34
2
35
3. CT scan of Normal Brain
37
4. Hydrocephalus CT Brain (Diagnosis of Hydrocephalus by CT brain)
39
5. CT brain of Hemorrhagic Stroke
40
6. (Factors affect outcome)
44
7. CT scan
46
(Risk of hematoma expansion after initial CT Scan)
8. (case study)
47
53
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1
2
3
4
5
6
7
8
9
vi
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(Initial management and Diagnosis of stroke)
(Classification of Hemorrhagic Stroke by Location)
Lobar Hemorrhage
(Management of Lobar Hemorrhage)
Basal Ganglia
(Management of Basal Ganglia Hemorrhage)
Thalamus
(Management of Thalamic Hemorrhage)
(Management of Cerebellar Hemorrhage)
brainstem
(Management of Brainstem Hemorrhage)
Subarachnoid Space
(Management of Subarachnoid Hemorrhage)
4
6
12
14
16
17
19
23
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1 (Strength of Recommendation)
2 (Quality of Evidence: QE)
3 (Strength of recommendation)
(Strength of Recommendation)
4
(Medical Management in Acute Phase of Hemorrhagic Stroke)
5
(Treatment of Increased Intracranial Pressure)
6
(Guidelines for Neurosurgical Consultation in Hemorrhagic Stroke)
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26
28
29
30
31
32
33
vii
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1
2
3
4
5
6
7
8
viii
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(Calculation of Volume of Hematoma)
CT Scan of Normal Brain
Hydrocephalus CT Brain
(Diagnosis of Hydrocephalus by CT brain)
CT Brain of Hemorrhagic Stroke
(Factors affect outcome)
(Risk of hematoma expansion after initial CT Scan)
(Case study)
34
35
37
39
40
44
46
47
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(stroke, cerebrovascular disease)
1 ..2553
(Public Health Statistics A.D.2010)2 3
(20.6 )
1 2
(Disability Adjusted Life Year) 2 3
Stroke means rapidly developed clinical signs of focal (global) disturbance of cerebral
function lasting more than 24 hours or leading to death, with no apparent cause other than a
vascular origin.4
5
2551
- CT brain (computerized tomography brain)
CT scan
Siriraj Stroke Score
- Cerebellar hemorrhage
- Subarachnoid hemorrhage
-
-
-
-
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(Quality of Evidence: QE) 2 A, B, C I,II,III IV
(strength of recommendation) 5 ++, +, +/-, - --
( 1 - 3)
3
1.
2.
3.
4.
2
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(Guidelines for the management of hemorrhagic stroke)
(hemorrhagic stroke)
10-15 35-52 30 6,7
1 508
2553 39,948
63 100,000 9
10
11,12
24 23-38 13
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Advanced life support & emergency lab.
CT Brain non contrast
No**
Normal/Hypodensity
CT brain scan
Hyperdensity/Mass
Ischemic
stroke/Others
Yes
Hemorrhagic
Stroke
4
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sudden neurological deficit vital signs,
neurological signs emergency advanced life support airway,
ventilation Glasgow Coma Scale (GCS) score < 8
aspiration emergency laboratory tests
Sudden onset of persistent focal neurological deficit and no history of head trauma
probability of stroke 80%14
acute stroke CT brain 15 ischemic
hemorrhagic stroke
(systolic blood pressure) 220 .. 170 ../. (
) anticoagulant antipaltlate warfarin aspirin
CT brain ischemic stroke
hemorrhagic stroke
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SAH & IVH*
SAH & ICH*
Primary IVH
IVH
ICH & IVH*
= Intracerebral hemorrhage
ICH
ICH
IVH
= Intraventricular hemorrhage
ICH & IVH
Lobar
= ICH in cortical or subcortical area
Primary SAH
Non-lobar = ICH in basal ganglia, thalamus, brain stem, cerebellum Primary IVH
SAH
= Subarachnoid hemorrhage
SAH & ICH
Primary IVH = IVH
SAH & IVH
* primary hemorrhage
Primary SAH
SAH
Hemorrhagic stroke
ICH
Lobar
3-7 ( 8,11,13,15,17)
3-7 ( 8,11,13,15,17)
3-7
Non-lobar
CT
brain CT brain
hemorrhagic stroke 3 subarachnoid hemorrhage (SAH),
intraventricular hemorrhage (IVH), intracerebral hemorrhage (ICH)
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(Surgical Management of Hemorrhagic Stroke)
/ arteriovenous malformation (AVM), aneurysm
8
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Lobar Hemorrhage
(Management of Lobar Hemorrhage)
HCP**
or
or
SAH
or
Temporal lobe
hematoma
Lobar hemorrhage
Criteria > 2
Criteria < 2
Medical treatment
Worse*
Improved ( 9)
Lobar hemorrhage
1. CT brain abnormal vessels
2. < 45
3.
Discharge
= 0.524 X Y Z
(X,Y,Z = X,Y,Z )17
* (extracranial cause)
2
** 4
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GCS = Glasgow Coma Scale
HCP = Hydrocephalus
IVH = Intraventricular hemorrhage
SAH = Subarachnoid hemorrhage
Hematoma CT brain CT brain
24 onset15 ( 7)
Lobar hemorrhage intracerebral hemorrhage (ICH) cortical
subcortical frontal, temporal, parietal, occipital lobes
cerebral amyloid angiopathy, aneurysm, AVM
> 2 GCS < 1319,20, volume > 30 ml.21, midline shift > 0.5 cm.22
1
(medical treatment)
< 45 CT brain abnormal blood vessels
cerebral angiography23 - 25
temporal lobe early brain herniation 21
10
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Non-Lobar Hemorrhage
Non-lobar hemorrhage intracerebral hemorrhage basal ganglia (
putamen), thalamus, cerebellum, brainstem ( pons)
45 CT brain
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Basal Ganglia
(Management of Basal Ganglia Hemorrhage)
HCP***
or
or
SAH
Criteria > 2
Criteria < 2
Medical treatment
Worse*
Improved ( 9)
Discharge
= 0.524 X Y Z
(X,Y,Z = X,Y,Z )17
* Basal ganglia hemorrhage putamen, globus pallidus
caudate nucleus ( 5 40)
** 2
GCS = Glasgow Coma Scale HCP = Hydrocephalus
IVH = Intraventricular hemorrhage SAH = Subarachnoid hemorrhage
*** 4
12
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Basal ganglia hemorrhage > 2 GCS < 13,
volume > 30 ml. 26, midline shift > 0.5 cm. 22 < 2
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Thalamus
(Management of Thalamic Hemorrhage)
HCP
or
Thalamic hemorrhage
Criteria > 2
Criteria < 2
Medical treatment
Worse*
Improved ( 9)
Discharge
= 0.524 X Y Z
(X,Y,Z = X,Y,Z )12
* 2
GCS = Glasgow Coma Scale
HCP = Hydrocephalus
IVH = Intraventricular hemorrhage
** 4
14
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Thalamic hemorrhage > 2 GCS < 13, volume > 10 ml.27,28,
midline shift > 0.5 cm. / hydrocephalus (HCP)
< 2 hydrocephalus
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Cerebellar hemorrhage
* (refer case)
6
Cerebellar hemorrhage hemorrhagic stroke
hemorrhagic stroke
Cerebellar hemorrhage
hydrocephalus
16
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brainstem
(Management of Brainstem Hemorrhage)
Criteria
Brainstem hemorrhage*
for neurosurgical consultation
1. GCS < 13
2. HCP ***
3. IVH with HCP
Criteria > 1
Criteria = 0
Medical treatment
Worse*
Improved ( 9)
Discharge
GCS = Glasgow Coma Scale
HCP = Hydrocephalus
IVH = Intraventricular hemorrhage
* signs brainstem dysfunction 2
** Repeated episodes Brainstem hemorrhage
*** 4
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7
Brainstem hemorrhage pons GCS < 13
hydrocephalus (HCP) intraventricular hemorrhage with HCP
(repeated episodes) cavernous
angioma GCS > 13
hydrocephalus
18
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Subarachnoid Space
(Management of Subarachnoid Hemorrhage)
Other diagnosis
Negative for SAH
Positive
for SAH
+ ICH / IVH
LP for CSF analysis
Normal or Other diagnosis
(persistent RBC
SAH
+/- xanthochromia)
Appropriate management
CSF =
CT brain =
ICH =
IVH =
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8
Subarachnoid hemorrhage (SAH) subarachnoid space
SAH ruptured aneurysm, ruptured AVM, blood dyscrasia,
head injury, parasite
SAH CT brain CT brain SAH
SAH parasite
SAH 2
CT brain
20
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(Medical Management in Acute Phase of Hemorrhagic Stroke)
(Blood pressure management)
ICH
SAH 4
(Management of body temperature)
brain
metabolism 29 4
(Management of Blood Glucose)
stress 30
> 140 ./.
(Prevention of Seizure)
ICH (grade C)
(grade A)
isotonic solution normal saline
4
(Management of increased intracranial pressure)
pulse pressure
5
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21
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22
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(1)
(2)
(2)
2 (3)
1 (3)
2 .. (4)
1/2 .. (4)
(7)/
(8)
(5)
(6)
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9
(1) 31
48
(2)
2.1
- (motor function assessment)
- (sensory assessment)
- (coordination)
- (range of motion)
- (muscle tone)
2.2
-
-
2.3
2.4
2.5 (cognitive and perception assessment)
2.6 (Bowel and bladder function)
2.7
2.8
*
(3) 2
1
24
(4)
24
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(5) 31
2 3
(6)
1 2
2-3
(7)
7.1
7.2
7.3
7.4
7.5
(8)
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++
1.
(QE = I) 32 - 34
2.
++
+/-
+/-
+/-
2.5 Diazepam
(QE = II-2)41
2.2
Tizanidine Baclofen
Tizanidine (QE = II-1)36
3.
++
3.1
++
3.2
3.3
++
4.1
++
4.2
+/-
++
5.
(QE = III)44 - 46
26
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- 38 C
- > 100 < 60 /
- SBP >180 < 90 DBP > 110 < 60
-
-
-
-
-
-
-
-
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1 (Strength of Recommendation)
Grade
Recommendation
28
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(systemic review) -
(randomized-controlled clinical trials)
-
(a well-designed, randomized-controlled, clinical trial)
(non-randomized,
controlled, clinical trial)
(well-designed, non-randomized,
controlled clinical trial)
(cohort)
(case control analytic studies)
/
(multiple time series)
..
III
III-1
III-2
(descriptive studies)
(fair-designed, controlled clinical trial)
IV
IV-1
(consensus)
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3 (Strength of recommendation)
(Strength of Recommendation)
++
(cost effective) /
(strongly recommend)
/ (recommend)
+/-
(neither recommend nor against)
(against)
--
(strongly against)
30
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31
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32
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Lobar
Temporal lobe
Basal ganglia
Thalamus
Cerebellum
Pons
Subarachnoid
hemorrhage (SAH)
Primary intraventicular
hemorrhage (IVH)
Hydrocephalus (HC)
(criteria)
1. GCS < 13
2. Volume > 30 ml
3. Midline shift > 0.5 cm.
1. GCS < 13
2. Volume > 30 ml
3. Midline shift > 0.5 cm.
1. GCS < 13
2. Volume > 10 ml
3. Midline shift > 0.5 cm.
1. GCS < 13
2. HC
3. IVH
4. Repeated episodes
-
Criteria < 2
Criteria > 2
Criteria < 2
Criteria > 2
Criteria < 2
Criteria > 2
Criteria = 0
Criteria > 1
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(Calculation of Volume of Hematoma)17
(volume of hematoma) = 0.524 * X * Y * Z
(X, Y, Z X, Y, Z)
34
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1. Vital signs:
a. Blood pressure (BP): Cushings reflex BP
Pulse pressure
b. Heart rate (HR): Cushings reflex HR
c. Respitatory rate (RR): (worse)
RR Apnea
2. Glasgow Coma Scale (GCS) : GCS score 2
3. Pupil:
a. Size: pupil Brain herniation (uncal herniation)
b. Equality: pupil 1 mm
c. Reaction to light: pupil Brain herniation (uncal
herniation)
pupil (
)
4. Motor power: motor power 1 grade
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36
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37
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38
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Hydrocephalus CT Brain
(Diagnosis of Hydrocephalus by CT brain)
Hydrocephalus was defined as the presence of
1. The presence of a dilated contralateral temporal horn.
2. Unilateral dilated frontal and posterior horn of the lateral ventricle from deep cerebral
hemorrhage.
3. Bilateral dilated lateral ventricles with or without a dilated third ventricle resulting from
obstruction by a clot in the ventricle or the mass effect of deep cerebral hemorrhage.
4. The frontal horn is considered to have enlarged if there is an increased radius, decreased
ventricular angle, and sulcal effacement of the frontal lobe.
5. The posterior horn is considered to have enlarged if there is rounding of the posterior horn
with sulcal effacement of the parieto-occipital lobe.
6. The third ventricle is enlarged if the width is increased (> 7 mm.) and if there is ballooning
of the anterior recess.
7. The fourth ventricle is considered enlarged if there is bulging.
8. The bicaudate index : > 0.15 = ventricular enlargement
9. Evans ratio (index)is the ratio of maximum with of the frontal horns to the maximum with
of the inner table of the cranium = A/B > 0.3 in hydrocephalus
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3
Frontal lobe
4
Temporal lobe
5
Parieto-occipital lobe
6
Small hemorrhage
at putamen
7
8
Classical hemorrhage Large basal ganglia hemorrhage
at globus pallidus
with secondary IVH
40
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Thalamic hemorrhage
9
Small thalamic hemorrhage
10
Large thalamic hemorrhage
with secondary IVH
11
Cerebellar hemorrhage
12
Small pontine hemorrhage
13
Large Pontine hemorrhage
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14
Diffuse subarachnoid hemorrhage
15
Intraventricular hemorrhage in bilateral
ventricles and small amount of subarachnoid
hemorrhage along bilateral sylvian fissures
16
Intraventricular hemorrhage
in the 3rd ventricle and lateral ventricle
17
Intraventricular hemorrhage
in the 4th ventricle
42
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3-4
5-12
13-15
(, cc.)**
>30
<30
tentorium
()
>80
<80
*Glasgow Coma Scale
** (A X B X C) / 2
2
1
0
1
0
1
0
1
0
1
0
44
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Intracerebral Hemorrhage
50
Glasgow coma score, 80 , ,
(intraventricular extension) tentorium
cerebellum (infra-or supra-tentorial location) ICH score
51 A x B x C / 2
A B C
slides 3 ICH score
52 - 54 ICH score functional
outcomes 1 7 55
Spot sign CT angiogram 24
spot sign score
spot sign score 54
spot sign score 9
1 45% 51% 51, 57- 59
meta-analysis 1 40.4%
1980 2008 60 2 56%
61%58 2.7% 16% 1 61
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(Risk of hematoma expansion after initial CT Scan)
The cutpoint for hematoma enlargement was determined as
V2-V1 = 12.5 cm3 or V2/V1 = 1.4 (sensitivity = 94.4%, specificity = 95.8%).
Kazui et al18 CT scan
Initial CT scan at 3 hours after onset of stroke 36%
Initial CT scan at 3 to 6 hours after onset of stroke 16%
Initial CT scan at 6 to 12 hours after onset of stroke 15%
Initial CT scan at 12 to 24 hours after onset of stroke 6%
Initial CT scan at 24 to 48 hours after onset of stroke 0%
( V1 = initial CT scan, V2 = second CT scan)
CT scan brian hematoma expansion
CT scan
alcoholic abuse; an irregularly shaped hematoma, and a low level of fibrinogen.50
46
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(Case study)
Case 1
- 41 .
- 8 ..
- BP 160/90 PR 80/min Temp 36.4 RR 17/min Blood Sugar 87 mg/dl PT, PTT normal
- GCS = 10, right hemiplegia
CT brain (at 8 hrs after onset):
- left putaminal hemorrhage, 3*4.3*2.1 cm., midline shift 3.3 mm.
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Case 2
- 71 . .
- 8 .
-
- 9 thalamus
48
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Case 3
- 58 .
- 8 .
: DM, HT
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Case 4
- 74
- 3 .
- Hyperthyroidism hypothyroidism
- Bradycardia, Heart AF
BP 170/100 mm.Hg PR 80/min Temp 36.8 RR 15/min.
- GCS = 9, Left hemiparesis Grade I
- Pupils Rt. 3 mm. RTL, Lt. 2 mm. sluggish RTL.
CT brain (3 hrs. after onset): right basal ganglia hematoma size = 6.9*4.6*7.0 cm. effacement of
right ventricle
50
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Case 5
- 72 .
- 2
: Old CVD, HT, Aspirin
: BP 140/ 90 mm.Hg PR 98/min Temp 36.8 RR 15/min.
- GCS = 15, pupils 3 mm. RTL. BE.
- Left hemianopia
CT brain (48 hrs. after onset) : right occipital lobe hematoma, size = 1.7*2.8*3.0 cm.
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Case 6
- 44 .
- 3
: 8 1 20
: BP 138/77 mmHg PR 90/min Temp 36 RR 15/min.
- GCS = 15 pupils 2 mm. RTL., no weakness
CT brain (72 hrs. after onset) : Left parietal lobe hematoma, size = 3.0*1.3*2.1 cm.
Dx. Lobar hemorrhage at left parietal lobe
Management
1. Volume of hematoma = 3.0*1.3*2.1*0.524 = 4.29 cc.
2. lobar hemorrhage CPG criteria 0
medical Rx
3. BP 138/77 mmHg criteria anti-hypertensive conservative &
supportive Rx
4. CT brain 72 . onset expanding hematoma
( 7)
5. Dx, management, risk
6. 45
intracranial vascular study vascular abnormality
52
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1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
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13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
54
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27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
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39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
Brashear A, Gordon MF, Elovic E et al. Intramuscular injection of botulinum toxin for
the treatment of wrist and finger spasticity after a stroke. N Engl J Med 2002; 347: 395-400.
Childers MK, Brashear A, Jozefczyk P, Reding M, Alexander D, Good D, Walcott JM,
Jenkins SW, Turkel C, Molloy PT. Dose-dependent response to intramuscular botulinum toxin
type A for upper-limb spasticity in patients after a stroke. Arch Phys Med Rehabil 2004; 85:
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