DRUG STUDY

DRUG NAME BCG Vaccine MECHANISM OF ACTION A live attenuated bacterial vaccine prepared from Mycobacterium boris that promote attenuated active immunity to TB Promotes active immunity to DTP by inducing production of antitoxins and antibodies INDICATIONS Tuberculosis exposure CONTRAINDICATIONS >Contraindicated in patients receiving corticosteroid therapy. >Avoid use in pregnant patients >use cautiously in patients with chronic skin disease. ADVERSE REACTIONS Musculoskeletal: osteimyeloitis Other: lymphadenopathy, allergic reaction CNS: seizure, fever, drowsiness GI: Anorexia, vomiting Skin: tenderness,redness and fretfulness CNS: Headache,fever, dizziness, insomnia, paresthesia EENT: Pharyngitis GI: Anorexia, diarrhea,nausea NURSING RESPONSIBILITIES >Dont inject vaccine IV,SC, ID >Inject epinephrine 1:1,000 available to treat anaphylaxis

Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed (DtaP)

>Primary immunization >Booster immunization

>Contraindicated in adults or children

Hepatitis B vaccine, recombinant

Promotes active immunity to hepatitis B

Immunization against infection from all known subtypes of hepatitis B

Contraindicated in patients hypersensitive to yeast or components of vaccine.

>Give only by deed IM injection preferably in thigh or deltoid muscles >In infants, give IM injection in the Anterolateral thigh >Recombinant hepatitis B vaccine isnt made with human plasma products. >Give vaccine in deltoid muscle for adults and adolescents.

DRUG STUDY

DRUG NAME Measles vaccine,live attenuated

MECHANISM OF ACTION Promotes immunity to measles virus by inducing production of antibodies

INDICATIONS >Immunization > Measles outbreak control

CONTRAINDICATIONS >Dont give vaccine within 3 months of receiving

ADVERSE REACTIONS CNS:febrile seizures in susceptible children, fever GI: anorexia Hematologic: leucopenia Skin: rashes, swelling,tenderness CNS: fever, sleepiness GI: decreased appetite Skin: Injection site erythema, induration, pain

NURSING RESPONSIBILITIES >Dont give vaccine IV >If skin is needed, give either before or simultaneously with vaccine.

Poliovirus vaccine, inactivated

Promotes immunity to poliomyelitis by inducing humoral antibodies and antibodies in the lymphatic tissue.

Poliovirus immunization

Contraindicated in patients hypersensitive to neomycin, streptomycin or polymyxin B and in neonates younger than age 6 weeks.

>vaccine isnt effective in modifying or preventing existing or incubating poliomyelitis >Vaccine may temporarily decrease response to tuberculin skin test.