Clinical vignette

r old female develops severe belt-like abdominal

ter having a gallbladder surgery. Cullen and Grey
signs visible on abdominal wall. Amylase was very h
rum calcium too low. After 2 days of treatment the p
hypovolemic shock
-TYPE OF NECROSIS
-MECHANISM
-THE CLEAR YEWLOWISH AREAS REPRESENT…
-DIAGNOSIS…
 CELL INJURY &
DEATH: PART II
R. HUGO MARTÍNEZ LOZANO, M.D.

August 29, 2006.

 LEARNING OBJECTIVES: K & U
 REVERSIBLE & IRREVERSIBLE
 NECROSIS

- MORPHOLOGY
- TYPES
- EXAMPLES
 APOPTOSIS

- MORPHOLOGY
- TYPES
- EXAMPLES
 INTRACEL. ACCUMULATIONS

- IDEM.
Ref: pp. 19-32, 34-40 % lecture’s info
 EXAMPLES OF CELL INJURY &
NECROSIS
 ISCHEMIC/HYPOXIC
 ISCHEMIC-REPERFUSION
 CHEMICAL
 Clinical vignette:
o male is admitted in the ER c/o severe abdominal pa
being evaluated he is taken to surgery, where you a
see this image:
mpare with this slide of the patient’s small bowel
ich structures are preserved, which have changed?
k for normal cellular shapes and nuclear appearance
REPERFUSION DAMAGE
 TYPES OF NECROSIS
 COAGULATION
 LIQUEFACTION
 GANGRENOUS
 CASEOUS
 FAT (ENZYMATIC)
COAGULATION NECROSIS
IDEM
ABSCESS: TOPOGRAPHY?
LUNG & LYMPH
NODE: TB
FAT (ENZYMATIC) NECROSIS
2 PATHS:
-INT.
-EXT.
ULTRASTRUCTURE:
APOPTOTIC
BODY
TYPES OF ACCUMULATIONS
 LIPIDS
 PROTEINS (HYALINE INCLUDED)
 GLYCOGEN
 PIGMENTS
FATTY LIVER