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    This document provides an overview of hemodynamic disorders including thrombosis, disseminated intravascular coagulation (DIC), embolism, infarction, and shock. It discusses various causes of endothelial injury that can lead to thrombosis, as well as conditions that cause hypercoagulability such as genetic mutations and immobilization. The stages of thrombus evolution and types of embolism like fat, air, and septic embolism are outlined. Features of infarction including red hemorrhagic and white anemic types are described. Finally, the document covers definitions of shock, types of shock including septic shock, and morphology in conditions like septic shock.

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    This document provides an overview of hemodynamic disorders including thrombosis, disseminated intravascular coagulation (DIC), embolism, infarction, and shock. It discusses various causes of endothelial injury that can lead to thrombosis, as well as conditions that cause hypercoagulability such as genetic mutations and immobilization. The stages of thrombus evolution and types of embolism like fat, air, and septic embolism are outlined. Features of infarction including red hemorrhagic and white anemic types are described. Finally, the document covers definitions of shock, types of shock including septic shock, and morphology in conditions like septic shock.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    75 views58 pages

    Hemodynamic Disorders II

    Uploaded by

    uagmed2012
    This document provides an overview of hemodynamic disorders including thrombosis, disseminated intravascular coagulation (DIC), embolism, infarction, and shock. It discusses various causes of endothelial injury that can lead to thrombosis, as well as conditions that cause hypercoagulability such as genetic mutations and immobilization. The stages of thrombus evolution and types of embolism like fat, air, and septic embolism are outlined. Features of infarction including red hemorrhagic and white anemic types are described. Finally, the document covers definitions of shock, types of shock including septic shock, and morphology in conditions like septic shock.

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    of 58

    HEMODYNAMIC

    DISORDERS II

    R. HUGO MARTÍNEZ LOZANO, M.D.

    SEP-06, 2006
    LEARNING OBJECTIVES
    KNOW & UNDERSTAND THE MOST
    IMPORTANT FEATURES RELATED WITH:
    - THROMBOSIS – Pathogenesis

    - Causes
    - Morphology
    - D.I.C. (General features)
    - EMBOLISM – types

    - INFARCTION

    - SHOCK – Types

    - Septic shock – Pathogenesis


    - Morphology
    - ¡¡¡ CLINICAL SIGNIFICANCE !!!

    Ref: pp. 130-142 & lecture’s information


    ENDOTHELIAL INJURY
     TOBACCO SMOKE
     BACTERIAL LPS
     ELEVATED HOMOCYSTEINE
     ELEVATED LDL
     RADIATION
     VASCULITIS
     ETC.
    ABNORMAL BLOOD FLOW
     TURBULENCE
     STASIS
    M.I.
    VENOUS
    INSUFICIENCY
    HYPERCOAGULABILITY STATES
     PRIMARY: MUTATIONS IN:
    - FACTOR V GENE (LEIDEN)
    - PROTHROMBIN GENE
    - METHYLTETRAHYDROFOLATE GENE
    (HYPERHOMOCYSTEINEMIA)
    - OTHER
    HYPERCOAGULABILITY STATES
     SECONDARY:
    - IMMOBILIZATION
    - M.I.
    - ATRIAL FIBRILLATION
    - TISSUE DAMAGE
    - CANCER
    - CARDIAC VALVES PROSTHESIS
    - D.I.C.
    - ANTI-PHOSPHOLIPID SX.
    - OTHER: ESTROGENS, SMOKING.
    DISSEMINATED INTRAVASCULAR
    COAGULATION (D.I.C.)
    THROMBUS: EVOLUTION
     PROPAGATION
     EMBOLIZATION
     DISSOLUTION/RECANALIZATION
     RESOLUTION
    VENOUS
    INSUFICIENCY

    IDEM
    EMBOLIZATION,
    PULMONARY
    THROMBO-EMBOLISM
    SMALL
    PULMONARY
    INFARCT
    EMBOLISM: TYPES
     FAT
    EMBOLISM: TYPES
     AIR
    EMBOLISM: TYPES
     NEOPLASTIC
    EMBOLISM: TYPES
     AMNIOTIC
    FLUID
    EMBOLISM: TYPES
     SEPTIC
    INFARCTION
    ISCHEMIA------------------------
    NECROSIS

    MORPHOLOGY – RED
    - WHITE
    RED (HEMORRAGHIC) INFARCT
    RED (HEMORRAGHIC) INFARCT
    RED (HEMORRAGHIC) INFARCT
     INTESTINAL INFARCT (SMALL INT.)
    WHITE (ANEMIC) INFARCT
     KIDNEY
    RENAL (OLD)
    INFARCT
    WHITE (ANEMIC) INFARCT
     SPLEEN
    PULMONARY
    THROMBOEMBOLISM
    SHOCK: DEFINITON.
    SHOCK: TYPES
     HYPOVOLEMIC
     CARDIOGENIC
     NEUROGENIC
     SEPTIC
     “TOXIC”
     ANAPHYLACTIC
    MORPHOLOGY: SNC
    “SHOCK KIDNEYS”
    ACUTE TUBULAR NECROSIS
    SEPTIC SHOCK

    PATHOGENESIS
    SEPTIC SHOCK
    QUESTIONS?

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