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In the April 2008 issue of the Harvard Health Letter, researchers highlight

how to manage seven (7) common conditions without taking medication.


While no one should stop taking prescribed medication without talking to a
doctor, the researchers write that with discipline, the non-pharmacological
approach can do as much as pills in many cases.
Those 7 common conditions are:
Arthritis: There's a good chance that losing weight will make arthritis less
painful. Combine weight loss with exercise and you may have less pain and
more mobility. Even for those who don't need to lose weight, exercise that
doesn't put "load" on the joints, such as swimming, reduces pain.
Cholesterol: Your LDL level may drop by about 5 percent if you avoid
foods high in saturated fat. Additional soluble fiber may reduce LDL levels
as well, as can, can margarines fortified with sterols.
Cognitive decline: Memory training and other "brain exercises" seem to
help healthy older people stay sharp. But physical exercise may benefit the
brain more than mental gymnastics.
Depression: Regular physical activity can have a potent antidepressant
effect.
Diabetes: Exercise is a powerful brake on blood sugar levels, because
exercised muscle becomes more receptive to the insulin that helps it pull
sugar in from the bloodstream. Eating fewer sweets and easy-to-digest
carbohydrates also helps control blood sugar levels.
High blood pressure: Losing weight, getting more exercise, and eating
less sodium all lower blood pressure.
Osteoporosis: Weight-bearing exercise puts stress on bones, and bone
tissue reacts by getting stronger and denser, fending off osteoporotic
processes. Extra vitamin D and calcium top the list of dietary
recommendations.

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2008
(Harvard Health Letter) (7)

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Antidepressants may not work report


Antidepressant drugs may have little effect on patients, many
unpublished studies show.
January 16 2008: 6:39 PM EST

Anti-depressants may not be as effective as patients, and doctors,


believe.
NEW YORK (CNNMoney.com) -- Patients and doctors alike may have
received some fuzzy truth about the effectiveness of antidepressant
medication.
According to a report in The Wall Street Journal, many studies have found
that best-selling antidepressants like Wyeth's Effexor and Pfizer's Zoloft
may have little or even no effect on patients. Many of those studies, though
submitted to the Food and Drug Administration, were left unpublished.
Researchers accordingly suggested in this week's New England Journal of
Medicine that doctors and patients may not have been able to see the full
antidepressant picture.
Both Pfizer (PFE, Fortune 500) and Wyeth (WYE, Fortune 500) told The
Wall Street Journal that they will disclose all study results, but they will not
necessarily publish them in medical journals. The FDA does not require
pharmaceutical companies to publish the studies that they sponsor, which
leaves many studies unpublished.
Separately, 74 studies involving 12 antidepressant drugs were submitted to
the FDA between 1987 and 2004, 38 of which the FDA called "positive."
Though all but one of the "positive" studies were published, only 14 of the
36 "negative" studies were printed in medical journals.
But even with the large disparity of reports that the pharmaceutical
companies published, not all of the negative stories were all that "negative."

According to the NEJM researchers, at least 11 of the 14 "negative" studies


presented unfavorable findings as beneficial ones by highlighting positive
secondary outcomes and ignoring negative primary results.
The New England Journal of Medicine researchers believe this "publication
bias" can complicate doctors' understanding of the effectiveness of
medications. For instance, when considering all of the studies' data, the
researchers found that Zoloft only has a "small" effect on patients as
opposed to the "medium" effect that the mostly-positive results had shown.

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