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Technical Institute for Health Training

Review of

Pharmacy & Questions

Prepared by: Dr. Ramadan Al-Shdefat

2006
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Table of contents

1 Introduction 2 Pharmacology "#$&" ')* 3 Pharmaceutics +,-/0$-1&" ')* 4 Important Information 34,5 +,46)74 5 Questions 3.8-):/0"# 3-<=7&" 3?)&,< 3)@B" (1) !"$& (2) !"$& (3) !"$& (4) !"$& (5) !"$&

3 5 13 26

30

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Pharmacy

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Review of

Pharmacy

Introduction
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Test Structure
The test is a multiple-choice question written by pharmacists who, like most of your pharmacy instructors, have Ph.D / masterps degrees and clinical expertise in particular areas.
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The test is designed for one purpose: to determine whether itps appropriate for you to receive a license to practice as a pharmacy technician. By passing the test, you demonstrate that you possess the minimum level of knowledge necessary to practice pharmacy safely.

Testing by Computer
The test, like many standardized test today, is administered by computer, or by answered on computer sheet (filling the empty circles using sharpening pencils). A B C D 1. O O 2. O

q q

O O

3. O O O Donpt fill the circles in this way !!!!

To focus on the question and avoid becoming overwhelmed, apply proven strategies for answering the questions, including: Determining what the question asks. Rephrasing the question. Choosing the best option. Read the question twice. If the answer is not apparent, rephrase the question in simpler, more personal terms. Breaking down the question into easier, less intimidating terms may help you to focus more accurately on the correct answer.
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Pharmacology "#$&" ')*


Group
Tetracyclines

Generic Name
Doxycyclin Minocyclin Oxy-tetracyclin Chloramphenicol

Trade name
Vibramycin Minocine Terramycin Chloromycetin Kemicetine Orbenin Floxapen Methicillin

B-Lactamase stable Penicillin's

* Quinolones

Cloxacillin Flucloxacillin Methicillin Temocillin Amoxycillin + Potassium Augmentin Clavulanate Ciprofloxacin Norfioxacin Nalidixic acid Ofloxacin Erythromydn Clarithromycin Azithromycin Amikacin Gentamycin Kanamycin Neomycin-Sulphate Streptomycin Tobramycin Cephalexin Cephradin Cephadroxil Cefuroxime Cefaclor Cefamndol
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Macrolides

Aminoglycosides

1st generation Cephalosporins 2nd generation Cephalosporins

Ciprobay Noroxin Negram Tarivid Erythrocin Klacid Zithromax Amikin Cidomycin & Garamycin Kantrex Mycifradin Streptocid Nebcin Keflex Velocef Ultracef Zinnat Ceclor Mandol
Pharmacy 5

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3rd generation Cephalosporins

Anti-TB

Antiviral

Anti-fungal

Cefotaxime Ceftazidime Ceftizoxime Cefodizime Cefexime Cefprozil Rifampicin I.N.H. Ethambutol Streptomycin Acyclovir (herpes) Famciclovir Amantadine Iduroxidine (herpes) Zidovudine (AIDS) Griseofulvin Ambisome Itraconazole Ketoconazole Miconazole Nystatin Clotrimazole Econazole Fluconazole Chloroquine Primaquine Pyremethamine Pyremethamine + Sulphadoxine Mefloquine Metronidazole Tinidazole Sodium Stibo-gluconate

Claforan Fortum

Suprax Cefzil

Zovirax Symmetrel Retrovir Fulcin Amphotericin Sporanox Nizoral Daktarin Mycostatin Canesten Pevaryl Diflucan Malarex & Resochin Primaquine Daraprim Fansidar Mephaquine Flagyl Fasigen Pentostam Vermox Antepar Combantrin
Pharmacy 6

Antimalarial drugs

Antiprotozoal Leishmaniasis

Thread worms Mebendazole (Pinworms, Entrobius or Piperazine Vermucularis) Pyrantel


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Ascaricides (common round worm) Taenia Schistosomecide 1st generation Sulphonyl-urea 2nd generation Sulphonyl-urea

Mebendazole Piperazine Pyrantel Levamisole Hcl Niclosamide Oxamaquine Praziquantal Tolbutamide Chlorpropamide Acetohexamide Glibenclamide Gliclazide Glipizide Metformin Chlorpheneramine maleate Pheneramine maleate Clemastine Dimethindene Hydroxyzine Ketotifen Triprolidine Antazoline Astemizole Cetrizine Loratedine Terfenadine Clemastine Cimetidine Ranitidine Famotidine Omeprazole

Vermox

Biguanide

Anti-histaminic (sedative)

Ketrax Yomesan Vansil Biltricide Rastinon Diabenase Dimelor Daonil & Euglocon Diamicron Minidiab Glucophage & Melbin Analierg & Polararnin Avil Tavegyl Fenistil Atarax Zaditen Actidil Antistine Hismanal Zyrtec Claritine Teldane &Triludan Tavigyl Tagamet Zantac Pepcidin Losec

Antihistaminic (non-sedative)

Antihistaminic H1 selective antagonist Anti-ulcerative H2 selective antagonist Anti-ulcerative Gastric acid suppressor

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Pharmacy

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Antispasmodic

Oral Anti-emetic

NSAID's

Mucolytic

Expectorant

Cough sedatives

Hyoscine N-Butylbromide Buscopan & Spasmopan Mebevrine Hcl Duspataline Peppermint Oil Colpermin Metoclobramide Primpran & Plasil Chlorpromazine Largactil Promethazine Phenergan Dimenhydrate Dramamine Acetylsalicylic acid Aspirin Ibuprofen Brufen & Fenbid Diclophenac Sodium Voltaren Diflunisal Dolobid Fenbufen Cinopal Indomethacin Indocid Ketoprofen Profenid & Oruvail Nabumetone Relifex Naproxen Naprosyn & Proxen Phenylbutazone Tecinil Piroxicam Feldene Tenoxicam Tiicotil Tiaprofenic acid Surgam Tolmetin Tolectin Mefenamic acid Ponstan Bromohexine Hcl Bisolvon Carbocysteine Mucopront & Rhinathiol Acetylcysteine Mucomist Ammonium Chloride Ipecaqunnha Squill Gaufensin Codeine Dextromethorphan Phlocodeine Phlocodeine
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Cough sedatives + Decongestant

Antihistaminic + Decongestant

OTC

B1-Agonist B2-Selective Agonist

B2-Agonist

B2-blocker (glaucoma) B1& B2 Antagonists

Bl-Selective blocker (Cardie-selective)

Methadone Morphine Dextromethorphane + Benyline Diphenhydramine + Menthol Pholcodine + Ephedrine + Davenol Carboxamine Triprolidine + Actified Pseudo-Ephedrine Sudafed Plus Diphenyl-Pyraline + Escornade Phenyl-Propanolamine Paracetamol (500 mg) Panadol Ascorbic acid Redoxon Hyoscine N-Butylbromide Buscopan Bromohexine Hcl Bisolvon Pentoxiverine Toclase Aspirin Aspirin Mefenamic acid Ponstan Castor oil Adrenaline Adrenaline Isoprenaline Medihaler Orciprenaline Alupent Dobutamine Dopamine Salbutamol Ventolin Terbutalin Bricanyl Fenotrol Berotec Salmetrol Timolol Timptol Betaxolol Betopic Propranolol Inderal Pindolol Visken Timolol Timptol Nadolol Corgard Atenolol Tenormin Betaxolol Betoptic Bisoprolol Concor
Pharmacy 9

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Alpha & Beta-blocker Alpha-1 Selective blocker Antihypertensive

Metoprolol Acebutolol Labetalol Prazocin Clonidine Captopril Enalaphi Lisinopril Perindopril Quinapril Verapamil Nefidipine Deltiazem Isradipin Amiodipin Dipyridamole Digoxin Verapamil Adenosine Amiodarone Disopyramide Procainamide Quinidine Brytilium Lignocaine Mexiletine Phenytoin Propaphenone Tocamide Chlorothiazide Hydrochlorothiazide Chlorthalidone Indapamide Hydroflumethiazide Furosemide Bumetanide

Lopressor Sectral Trandate : Minipress Catapress Capoten Renitec Zestril Coversyl Acuitel Isoptin Adalat Dilziem & Teldium Lomir Arnlor Persantin

A.C.E.I.

Ca ++ channel blocker

Anti-platelets

Anti-arrhythmic (Supra-ventricular)

Cordarone Rhythmodari Kiditard

Anti-arrhythmic (ventricular)

Mexitil

Thiazide

Saluric Esidrex Hygerton Natrilex Lasix Burinex


Pharmacy 10

Loop (High) Ceiling Diuretics

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Potassium Sparing Diuretics

Spironolactone Triametrine Ascorbic acid (Vit C) Pyridoxine (Vit B6) Water soluble Vitamins Thiamin (Vit Bl) Riboflavin (Vit B2)
Cyanocopalamine (Vit B12)

Aldactone Redoxon Benadon Benerva

Retinol (Vit A) Ergocalciferol (Vit D2) Cholecalciferol (Vit D3) Fat Soluble Vitamins

One-Alpha (Alphacalcidol)

Anti-Estrogen Androgen antagonist

Lipid lowering drugs

Bulk forming laxatives

Tocopherol (Vit E) Ephynal Phytomenadione (Vit Kl) Konakion Synkavit Cloiniphen-Citrate Tamoxifen Nolvadex Cyproterone acetate Androcure Cholestyramine Questran Clofibrate Atromid S Gemfibrozil Lopid Simvastatin Zocor Provastatin Lipostat Bran Fybranta & Proctofibe Psyllium Hydrophilic Metamucil Mucilloid Methylcellose Sterculia Bisacodyl Anthraquinone Caster oil Cascara Arachis oil Paraffin oil Glycerol Magnesium salt Lactulose Normacol Dolcolax

Stimulant laxatives

Fecal softeners Osmotic laxatives

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Pharmacy 11

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Levodopa Antiparkinsonial (Dopaminernic)


Co-Beneldopa Madopar (Benserazide + Levodopa )

Antiparkinsonial (Antimuscarinics)

Co-Careldopa (Carbidopa + Levodopa ) Bromocriptine Benzhexol Benztropine Biperden H.C.G.

Sinemet Parlodel Artane Cogentin Akeniton Pregnyl Profassi Humegon Metrodin Pergonal

Hormones

F.S.H. (Menotrophin) F.S.H. (Urofollitrofin) F.S.H. + L.H. Somafropin Biosyn. Human Growth Geno(:ropin H. Noertropin Saizein Beclomethazone Sodium-Cromoglycate Allopurinol Kaolin + Pectin Loperamide Prostaglandin Short acting Insulin Aescin Theophylline-Choline Maprotiline Lorazepam Carbamazepine Disopyamide Ergotamine + Caffeine

Others

Becotide Intal Zyloric & Zyloprim Kaopetate Immodium Dinopstone Pancronium Reparil Choledyl Ludiomil Ativan Tegretol Rythmodan Cafergot

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Pharmacy 12

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Pharmaceutics +,-/0$-1&" ')*


Pharmaceutical Dosage Forms:
1. Liquid Dosage Forms:
A. B. C. Solid in Liquid dispersion (Suspension). Liquid in Liquid dispersion (Emulsion). Solution.

2. Semisolids Dosage Forms:


A. B. C. Ointment. Cream. Paste.

3. Solid Dosage Forms:


A. B. C. D. Powder. Tablets. Capsules. Granules.

4. Suppositories Dosage Forms:


A. B. Rectal route. Vaginal route.

5. Aerosols Dosage Forms:


These consist of pressurized pack which contains the drug in solution or suspension and suitable propellant.

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Pharmacy 13

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6. Ophthalmic Products:
The highest standards are necessary in the compounding of ophthalmic preparations and the greatest care is required in their use. It is necessary that all ophthalmic preparations (eye drops, eye lotions, eye ointments, contact lenses, and solid dosage forms) are sterile and essentially free from foreign particles.

7. Parenteral Solution:
Any product that is injected directly in to a fluid system of the body (Blood, lymph, intra or extra cellular liquids). It must be sterile and pyrogen free. A. B. C. Intravenous (I.V.). Intramuscular (I.M.). Subcutaneous (S.C.).

Solution:
- Is a homogenous mixture that is prepared by dissolving a solid, liquid or gas in another liquid.

Types of solutions: 1. Aqueous solution. - Douches. - Enemas. - Gargles. - Mouth washes. - Syrup.

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2. Non aqueous solution. - Elixirs. - Spirits. 3. Special types. - Tinctures. - Astringents. Solvent used to prepare solution: 1. Water (purified water, water for injection). 2. Alcohol (Ethanol). 3. Glycerin.

Emulsion (liquid in liquid dispersion):


- Are two phase system in which one liquid is dispersed through out another liquid. - Purpose of Emulsion: 1. Increase drug solubility. 2. Increase drug stability. 3. Prolong drug action. 4. Improve taste & appearance. Emulsion type : a. W/O b. O/W Method of preparation: 1. Dry gum method. 2. Wet gum method

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Pharmacy 15

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Suspension (solid in liquid or gas dispersion):


- Are two phase system consisting of finely divided solids dispersed in liquid or gas. Shelf life 7-14 days Shake the bottle before use.

Lotions:
Are liquid suspension intended for external application to the body. Ex Calamine Lotion, Benzyl benzoate. Shake the bottle before use. Store below 25rC. Using preservative to avoid contamination. Should be labeled for external use.

Ointment:
- Are semisolid preparations intended for external use. - Ointment bases: 1. Oleaginous or hydrocarbon bases. 2. Absorption bases. 3. Emulsion bases. 4. Water soluble bases. Methods of preparation: 1. Fusion method 2. mechanical incorporation
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a. Using glass mortar and pestle called trituration b. Using glass slab and spatula called as lavigation.

Creams:
- Are semisolid preparations usually either: 1. o/w emulsion (Aqueous cr.) 2. w/o emulsion (Oily cr.)

Pasts:
- Are concentrates of absorptive powder dispersed in petrolatum or hydrophilic petrolatum. - Are semisolid preparations intended for external use. - ** Paste differs from ointment in containing a large amount of finely powdered solid.

Tablets:
- Methods of preparation: 1. Wet granulation. 2. Dry granulation. 3. Direct compression. - Classification of Tablets: 1. Tablet for Oral ingestion. 2. Tablet used in oral cavity. 3. Tablet used to prepare solution.
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Tablets may be coated for number of reasons:1. To mask taste, odor, color of drug. 2. To control release of drug. 3. to protect drug from acid content of stomach. 4. To incorporate another drug and provide sequential release. 5. To avoid incompatibility. 6. To improve appearance. Enteric coated tablets:Are coated and remain intact in the stomach but give their ingredient in the intestine. E.g. ecotrin Coating materials are fats - fatty acid s waxes - PEG - Sugar and chocolate.

- Excipients of Tablets: 1. Diluents: Lactose s starch s cellulose. 2. Binder: Starch s cellulose s gelatin. 3. Disintegrate: Starch der. s Cellulose der.

4. Lubricant anti adherent and glidants: Magnesium and Calcium stearate. 5. Coloring agents. 6. Flavoring agents. 7. Sweeteners:- e.g. saccharin and aspartame

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Pharmacy 18

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- Processing problems: 1. 2. 3. 4. 5. Capping. Lamination. Picking. Sticking. Mottling.

Capsules
-Gelatin capsule may be hard or soft.

Pharmaceutical Calculations
Systems of Weights and Measures

Metric System:
1. Units of Weight: Name of the unit Kilogram Gram Milligram Microgram Abbreviation kg g mg g Relationship 1/1000 (0.001)kg 1/1000 (0.001)g 1/1000 (0.001)mg

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2. Volume: Name of the unit Liter Milliliter Micro liter 3. Length: Name of the unit Meter Centimeter Millimeter Abbreviation m cm mm Relationship 1/100 (0.01)m 1/1000 (0.001)m Abbreviation L ml l Relationship 1/1000 (0.001)L 1/1000 (0.001)ml

Conversion:
Exact equivalents are used for the conversion of specific quantities in the pharmaceutical formulas and prescription compounding 1. Mass 1 gram (g) = 15.432 grain 1 kilogram (kg) = 2.204 pound 1 grain (gr) = 0.065 mg 2. Volume 1 liter (l) = 35.2 fluid ounces = o.22 gallon

3. Length 1 meter (m) 1 inch (in) = 39.37 inches = 2.54 cm

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Pharmacy 20

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1 tea spoonful (tsp.)

= 5 ml

1 table spoonful (tbsp.) = 15 ml

1 milliliter (ml)

= 16 drops (dps or gtts)

Calculation of doses:
Total amount of doses = size of dose t number of doses

Example # 1: How many drops would be prescribed in each dose of liquid medicine in 15ml contained 60 doses? 1 ml = 32 drops 15 ml = ?? drops

480 dps or gtts

Size of dose = 480 dps / 60 doses = 8 dps or gtts

Example # 2: How many doses are found in 10g, if the dose is 200mg? Number of doses = 10g / 0.2g = 50 doses

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Example # 3: How many milliliters of liquid medicines would provide a patient with 2 table spoonful twice a day for 8 days? Total amount = 2 t 15ml x 2 t 8 = 480ml

Dosage Forms:
Iodine Solution 2% w/v Normal Saline 0.9% w/v Glycerol Solution 10% v/v Potassium Permanganate Solution 0.1% w/v Mercurochrome Solution 2% w/v Alcohol Solution 70% Dextrose Solution 5%

Apparatus: Baker, Watch glass, Measuring cylinder, Glass rod, Balance, Mortar, Pestle, Slab, Spatula. Percentage Concentration of Solution are Expressed as follow: 1. Percent weight in weight ( w/w ) EX. How many gram of substance are needed to prepare 200 gram of 10%w/w?

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2. Percent weight in volume ( w/v ) Ex.How many grams of drug are needed to make 120 ml of 25% solution?

3. Percent volume in volume (V/V) Ex How many ml of pure alcohol needed to make 500ml of 10% alcohol?

Examples: 1. Prepare 100 ml of 70% using 95% alcohol.

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Pharmacy 23

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Medication questions for further study: 1. On hand : Buscopan 20mg/ml Order : 5mg You Give:

2. On hand : Buscopan tablets 200 mg Order : 0.4g You Give:

3. On hand : Aminophylline 250mg/10ml Order : 75 mg add to I.V You Give:

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Other Concentration Expression Molarity (M): is the expression of the number of moles of solute dissolved per liter of solution. It is calculated by dividing the moles of solute by the volume of solution in liters

MA = moles of solute / volume of solution in L

EX.. How many grams of NaOH we need to prepare 0.5M solution of NaOH (MW=40g/mole) in 1L of H2O ?

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Pharmacy 25

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Important Information

34,5 +,46)74
Antidote (M,.=I&")
Protamine Sulphate N- Acetyl cysteine Vitamin K Naloxone Dimercaprol Penicillamine Deferoxamine Mesylate Pralidoxime Mesylate Edetate Disodium (EDTA)

3-&,* +,*=:< 34$GIKD&" 3.#%L"

Over dose
Heparin Paracetamol Warfarin Morphine Heavy metals Poisoning by Lead, Mercury & arsenic Toxicity by Iron Toxicity by Organophosphates Hypercalcemia

Vitamins Vitamin B1 Vitamin B2 Vitamin B6 Vitamin B12 Vitamin C Vitamin K

Generic Name Thiamine Riboflavin Pyridoxine Cyanocoblamine Ascorbic Acid Phytomenadione


Pharmacy 26

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"#$&" 'B" Warfarin Insulin Spironolactone ACE Inhibitor Heparin Tetracycline

NA"#% OH"$J QSKJ NI&" 3.#%L" ,DB" =HL" "#$&" T4 UV7J 0 NCX Aspirin, Vitamin K, Phenobarbital B- Blockers Digoxin Potassium Sparing Diuretics Aspirin, Ampicillin Antacid (Moxalu)

!"#$% &' ()*$+,-+. (/-0 1#2 ()&34 (/-0 54 6)&7*#8 9\5 t (32 - GQ53I&[I^/8 GDJZ/8) = Y6@D&" 3;>$&"

32 + (5\9 t G>"m$/8 GDJZ/8) = 3-J,C/=CZ&" 3;>$&"

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Pharmacy 27

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Abbreviations +">,1IH0" E7<


Abbreviation am aq ad as au
bid

Meaning morning water right ear left ear each ear twice a day capsule
a drop

Cap. gtt h hs inj nebul non rep noct no ou od os po


pc

hour at bed time injection a spray


do not repeat

pm prn pulv qs qd qh

at night number each eye right eye left eye by mouth after eating afternoon, evening when needed
a powder

quantity sufficient every day every hour

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Pharmacy 28

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qid soln stat supp syp tab tid tbsp tsp

four times a day solution immediately suppository syrup tablet three times a day
table spoon

tea spoon

[=H" +">,1IH" >,1IH0" ACE AIDS BP USP CNS G6PD HIV HRT NSAID u WHO S.N.F. U\7D&" Angiotesin s converting enzyme Acquired Immuno Deficiency Syndrome British Pharmacopoeia United State Pharmacopoeia Central Nervous System Glucose 6-phophate dehydrogenase Human Immuno Deficiency Virus. Hormone Replacement Therapy Non-Steroid Anti-inflammatory Drug Trade Mark World Health Organization Saudi National Formulary

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Pharmacy 29

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Questions 3.8-):/0"# 3-<=7&" 3?)&,< 3)@B0" ]4 +,*6D:4

(1) 9:&4,
! "#$% &'#( )&*!+, -$% .+/0# 1!+2 345 678/ 9/:! ;#:2#<:35 =2'+ !>! .1 .;$#B,/:! C3A#! (a :?5 @+A/

.;#:2#<:35 2+'+7:! 9:2#<:! D35E! (b .1!+2$: ;8H<7:! ;ID,:! D35E! (d :&$A:! ;$K% 13,/0! LM% 9( @2E/G/ ;#:3/:! ;#+2J! 7 .! .2 Isosorbid (a Metronidazole (b Amoxicillin (c .N5G 377 O, J (d :9H8/ (OTC);7$I: .3 .CD:! -$% Q2+'+7:! ;#+2P! (a .;#5R ;F<+ +25 34(D< 9:2#<$: I7# 9/:! ;#+2P! (b .;#5R:! ;F<+:! ;RG!+5 34(D< I7# 9/:! ;#+2P! (c 387 b & a (d
Technical Institute for Health Training Dr. Ramadan AL-Shdefat Pharmacy 30

.-F,/G7:! D#27 D35E! (c

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Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 89

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Q1. Select the best answer from the following multiple choice question? 1. The . rout offer instantaneous and complete absorption. a) Topical b) Oral c) I.V.* d) All of the above 2. Drug administered are exposed to first-pass metabolism. a) Orally* b) I.M. c) I.V. d) S.C. 3. The drug may be metabolized by the: a) Liver b) Kidney c) a & b* d) None of the above 4. The drug and its metabolites are eliminated from the body in: a) Urine b) Bile c) Feces d) All of the above* 5. The therapeutically index (TI) can be defined as: a) Toxic dose / effective dose* b) Toxic dose - effective dose c) Toxic dose + effective dose d) All of the above
Technical Institute for Health Training Dr. Ramadan AL-Shdefat Pharmacy 90

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6. Which one of these is a pro-drug? a) Ampicilline b) Erythromycin c) Levodopa* d) All of the above 7. Pharmacokinetics includes: a) Absorption & Distribution b) Metabolism c) Excretion d) All of the above* 8. Bioavailability is defined as: a) The action of the body on the drug b) Rate and extent to which the drug enters the systemic circulation* c) Remove of the drug from the body d) All of the above 9. If 100 mg of the drug is administered orally and 70 mg of this drug is absorbed unchanged, the bioavailability is: a) 100 % b) 10 % c) 70 %* d) 0 % 10. Total body clearance is the sum of the clearances from: a) Hepatic b) Renal c) Pulmonary d) All of the above* 11. The nervous system is divided into: a) Central nervous system and Peripheral nervous system* b) Peripheral nervous system only c) Brain d) Spinal cord
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12. OTC drug include: a) Simple analgesic e.g. paracetamol* b) Thyroxin c) Tetracycline d) Insulin 13. In Type I diabetes use: a) Insulin* b) Glibenclamide c) a & b d) None of the above 14. In Type II diabetes use: e) Insulin f) Sulphonyl urea* g) A & b h) None of the above 15. Side effects of Insulin are: a) Local reaction b) Hypoglcemia c) Fat hypertrophy at the infection site d) All of the above* 16. Which one of these drugs is a cough suppressant? a) Dextromethorphan* b) Captopril c) Pilocarpine d) Nalidixic acid 17. Theophyllin: a) Is a bronchodilator* b) Is a B2 agonist c) Causes bradycardia d) All of the above

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Pharmacy 92

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18. Nitrofurantoin is indicated for: a) Viral infection b) U.T.I* c) Asthma d) hypotension

19. Epinepherine is indicated for: a) Anaphylactic shock b) Asthma c) Nasal decongestant d) All of the above* 20. Timolol is indicated for: a) Hypertension b) Glaucoma c) a & b * d) None of the above

21. Which of the following drugs can cause addition? a) Barbiturates (Phenobarbital)* b) Tetracycline c) Iodine d) Frusemide 22. All of these medications are used in general anesthesia except: a) Nitrous oxide b) Diazepam c) Metronidazole* d) Morphine 23. Which one of these drugs used for treatment of Schizophrenia: a) Chlorpromazine* b) Rifampicin c) Azithromycin d) Salbutamol

Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 93

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24. All of these drugs are used in Epilepsy except: a) Carbamazepine b) Frusemide* c) Diazepam d) Phenytion 25. Captopril: a) Vasodilator b) Used for treatment of congestive heart failure c) a & b* d) None of the above 26. Diuretic drugs: a) Furosemide b) Indicated for treatment of edema and hypertension c) Spironolactone d) All of the above* 27. Antianginal drugs: a) Nitroglycerine b) Isosorbide dinitrate c) a & b * d) none of the above 28. All of these medications are antihypertensive except: a) Amlodipine b) Atenolol c) Timolol d) Ferrous gluconate* 29. Agents used in anemias: a) Ferrous gluconate b) Vitamine B12 c) Folic acid d) All of the above*

Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 94

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30. Anticoagulants: a) Reduce the formation of fibrin clots b) Heparin c) Warfarin d) All of the above* 31. Antiplatelet rugs: a) Increase the bleeding time b) Aspirin c) a & b* d) cloxacillin 32. Drugs used for treatment of hyperlipidemias: a) Lovastatine* b) Mebandazole c) Lorazepam d) None of the above 33. Aspirin: a) Acetylsalicylic acid b) Contraindicated in peptic ulcer c) Used for pain, inflammation, and fever d) All of the above* 34. Which of the following are newer Non-steroidal anti-inflammatory drugs (NSAIDs)? a) Ibuprofen b) Naproxen c) Indomethacine d) All of the above* 35. Drugs used in treatment of Asthma: a) Aminophylline b) Beclomethasone c) Cimetidine d) a & b*

Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 95

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36. Selective of the most appropriate antimicrobial agent requires of: a) The organism's identity and its sensitivity to a particular agent b) The site of the infection c) The safety of the agent and patient factors d) All of the above* 37. Penicillin and Cephalosporin: a) Are the major antibiotics that inhibit bacterial cell wall synthesis b) Called beta-lactams c) The microbial resistance poses constant challenge to the use of antimicrobial drugs d) All of the above* 38. Amoxicillin and Ampicillin: a) Cell wall synthesis inhibitors b) Used for treatment of infections caused by gram positive and gram negative c) Contraindicated in patient with penicillin hypersensitivity d) All of the above* 39. Which of the following statements are correct about Cephalosporin? a) The are classified for fourth-generations b) Dose not used for treatment of urinary tract infections c) Cefoxitin is a cephalosporin derivative d) a & b * 40. Protein synthesis inhibitors: a) Tetracyclin b) Gentamycin c) Clarithromycin d) All of the above* 41. Ciprofloxacin: a) It is a fluoroquinolones b) It is a bactericidal c) Used for treatment of respiratory and urinary tract infection d) a & b *

Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 96

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42. Drugs used for treatment of tuberculosis: a) Isonizaide (INH) b) Rifampin c) Ethambutol d) All of the above* 43. Which one of the following is not anti-fungal agent? a) Naproxen* b) Amphotericin B c) Miconazol d) Nystatin 44. Which one of the following drugs is not anti-viral agent? a) Amantadine b) Acyclovir c) Ribovirin d) Cephalexin* 45. Which of the following drugs used for AIDS? a) Metronidazole b) Clemastine c) Metoclobramide d) Zidovudine* 46. Which of the following drugs are disinfectants? a) Chlorhexidine b) Cresol c) Iodine d) All of the above* 47. Drugs used for treatment of allergies: a) Chlorpheniramine maleate b) Diphenhydramine hydrochloride c) Indomethacin d) a & b *

Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 97

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48. Which of the following drugs are used for treatment of constipation? a) Bisacodyl b) Magnesium sulphate c) Castor oil d) All of the above* 49. Drugs for treatment of gout: a) Codeine b) Allopurinol* c) Verapamil d) Atenolol 50. Drugs for treatment of peptic and duodenal ulcers: a) Morphine b) Cimetidine c) Omeprazol d) b & c * 51. To prevent more absorption of the toxic drug we use: a) water b) Salt sol. c) Saline d) Charcoal*

Q2. Drug movement and modification in the body are controlled by four fundamental pathways list its (pharmacokinetics)? 1. Absorption 2. Distribution 3. Metabolism 4. Excretion / Elimination

Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 98

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Q3. Give 5 examples of routes of drug administration? 1. Oral 2. I.V. 3. Transdermal 4. Topical 5. Rectal 6. I.M. 7. Inhalation 8. Sublingual

Q4. Match the following drugs with its therapeutical use? No. 1 2 3 4 5 6 7 Drug Pilocarpine Levodopa Ferrous gluconate Amitriptyline Phenytoin Captopril Nitroglycerin No. ( 6 ) ( 7 ) ( 3 ) ( 4 ) ( 5 ) ( 2 ) ( 1 ) Use CHF, Hypertension Angina Anemia Depression Epilepsy Parkinson's disease Glaucoma

Q5. Give one example on the following? 1. Drug for treatment of cough: .. 2. Drug used in treatment of Asthma: . 3. Antibiotic (cell wall synthesis inhibitor): .... 5. Cephalosporins: .. 6. Antibiotic (protein synthesis inhibitor): .... 7. Anti-fungal agent: .... 8. Anti-viral agent: . 9. General anesthetic: .. 10. Drug used in treatment of congestive heart failure: .
Technical Institute for Health Training Dr. Ramadan AL-Shdefat Pharmacy 99

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Q7. Fill in the blank with the suitable word? 1. The aim of drug therapy is to prevent , cure , and control various disease state. (cure, prevent, allergic, control) 2. Co-trimoxazole contain: trimethoprin + sulphamethoxazol (trimethoprin, sulphamethoxazol, ephedrine, cefazolin) 3. Absorption from the intestine is more efficient than absorption from the stomach. (Stomach, kidney, intestine) 4. The liver is the major site of drug metabolism. ( kidney, liver, heart) 5. The kidney is the major site of drug elimination. ( kidney, liver, heart) 6. Pharmacodynamics is the action of drug on the body. (drug, body) 7. Pharmacokinetics is the action of body on the drug. (drug, body) 8. Bactericidal: kill bacteria (kill bacteria, dose not kill bacteria) 9. Bacteriostatic : dose not kill bacteria (kill bacteria, dose not kill bacteria) 10. Caffeine, cocaine, and nicotine are CNS stimulants. Caffeine, nystatine, cocaine, nicotine) Q8. True or false: 1. Congestive heart failure is a condition in which the heart is unable to pump sufficient blood to meet the needs of the body. ( T ) 2. Diuretics agents that increase body fluid volume. 3. Antiseptic is an agent used to inhibit bacterial growth. 4. Nalidixic acid and nitrofurantoin are urinary antiseptic. 5. Acyclovir is an antimicrobial agent. ( F ) ( T ) ( T ) ( F )

Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 100

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Q9. Mention 2 drugs which are contraindicated in liver disease? - Methyltestosterone - Chlorpromazine - Erthromycin - Thiazides

Q10. Mention 2 drugs which are contraindicated during pregnancy? - Tamoxifen - Corticosteroid - Tetracycline - Salicylate - Misopristol - Digoxin

Q11. Give the abbreviations? - b.i.d. - t.i.d. - q.t.d.

meaning

of

the

following

Latin

prescription

twice daily three times a day four times a day

- a.c. - p.c.

before meal after meal

If there are any questions or notes, please do not hesitate contact us on the following address: KSA, Riyadh Technical Institute for Health Training Pharmacy Department Tel. 01 / 45555444 Ex. 233 or 225

Technical Institute for Health Training Dr. Ramadan AL-Shdefat

Pharmacy 101

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