PATHOPHYSIOLOGY

MODIFIABLE -immunodeficiency -certain chemical exposures -unknown, although, as with the leukemias, substantial evidence suggests a viral cause (eg, human T-cell leukemia-lymphoma virus, Epstein-Barr virus, hepatitis C virus, HIV).

Non-Modifiable -age -alcohol drinking

Mutation of proto-oncogens / disruption of tumor suppressor genes

Cell transformation

Transformed cell release of growth factors

Transformed cell release of growth factors

Painless enlargement of one or more lymph nodes on one side of the neck

Hepatic involvement or bile duct obstruction

Skeletal Involvement

Impaired lymph flow from serous cavity or erosion of tumor into the pleural cavity

retroperitoneal adenopathy

Dec. RBC

Impaired T Lymphocyte Function

Jaundice

Anemia

Inc. Susceptibility to opportunistic Infection

Pleural Effusion

Non-Hodgkins Lymphoma