USMLE Step 1 Web Prep Medically Important Viruses, Part 1

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Medical Virology

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Naked Virus

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Medical Virology

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Naked Virus

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Enveloped Virus

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DNA Viruses: Characteristics

!ll "N! Viruses: !re dou#le$s%randed& e'cep% (arvovirus !re icosa)edral& e'cep% (o'viruses *eplica%e %)eir "N! in %)e nucleus e'cep% (o'virus +a#le V$7, "N! VirusesVirus "N! %ype

Virion$

Envelope

.)ape

"N! replica%es Ma/or Viruses

0a1ily (arvo$ virus (apova$ virus !deno$ virus 5erpes virus ss"N!

associa%ed (oly1erase No Naked Naked Naked

in: 2cosa)edral Nucleus 2cosa)edral Nucleus 2cosa)edral& Nucleus 4i#ers 3$19 (apillo1a (olyo1a !denoviruses 5.V Varicella$9os%er Eps%ein$3arr :y%o1egalovirus Variola Vaccinia Molluscu1 con%agiosu1 5epa%i%is 3

ds"N! circular No ds"N! linear No

ds"N! linear

No

Nucleus8Virus Enveloped 2cosa)edral asse1#led in 6nuclear7 nucleus 3rick$ Enveloped s)aped& co1ple' Enveloped 2cosa)edral

(o'virus

ds"N! linear

;es--

:y%oplas1 Nucleus& *N! in%er1edia%e

5epadna$ par%iallyds"N! virus circular

;es---

-Mne1onic: (arva<s (apa !dds 5er (o'es %o 5epa<s --Poxviruses )ave a virio !associate" tra scri#tase 6"N! dependen% *N! poly1erase7 so i% can %ranscri#e i%s o=n "N! in %)e cy%oplas1 and 1ake all o4 %)e en>y1es and 4ac%ors necessary 4or replica%ion o4 %)e (o'virus "N! in %)e cy%oplas1, ---5epadnaviruses $ "N! viruses %)a% carry a "N! poly1erase =i%) reverse %ranscrip%ase ac%ivi%y %o syn%)esi>e an *N! in%er1edia%e %)a% is %)en used %o 1ake %)e geno1ic "N!, 5epa%i%is 3 is par%ially dou#le$s%randed =i%) one co1ple%e s%rand,