Jan 2009 by N

PHARMACIST
1. 2. 3. a. b. c. d. 4. a. b. c. d. Homeostasis as defined as ------ the body balance system In GLC, one of the phase is preferred ---------volatile (Gas) Which if the following vit acting as a hormone E B6 D3 A TSH is secreted from hypothalamus anterior pituitary posterior pituitary adrenal medulla

5. All of the following hormones secreted from anterior pituitary EXCEPT a) FSH b) LH c) ACTH d) ADH 6. a. b. c. d. Which of the following does not secrets in duodenum Mucus cell secretion Pancreas secretion Liver secretion Gall bladder secretion

7. Define Angiogenosis------ Formation of new blood vessels 8. 9. a. b. c. warfarin site of action is ------Liver Normally existed in blood prothrombin thrombin fibrin

10. The most effected cells with antineoplastic drugs a. neutrophils b. lymphocytes c. platelets

11. First cells on the site of inflammation are a. basophil b. neutrophil c. platelets 12. DOC for coagulation in pregnancy a. heparin b. warfarin c. ASA

13. A patient with cystitis should be counselled a. use diaphragm ( women who use the diaphragm are prone to inflammation) b. void after sex c. drink a lot of water 14. Uric acid production a. allopurinol b. probenecid c. uricosuric agent

by which drug

14. pencilline are small t 1/2 due to a. great protein binding b. active tubule secretion c. hydrolysis 15. Haemorrhoid patient can be advise to a. fiber diet b. Avoid prolong sitting time c. Avoid straining in toilet 16. poison IV which is not good advice a. loratadine b. epinephrine

17. sildenafil(PDE -5 inhibitor with nitrates do all EXCEPT a. hypertensive crisis b. hypotension c. erectile disfunctioning 18. Prazosin do all EXCEPT a. Orthostatic hypotension b. Hypertension crisis

19. Prazosin is
a. b. c. d. 1 antagonist 2 agonist 1 antagonist 2 agonist

20. The antidepressant work on epinephrine & dopamine, 5HT Dual action (SNRIS, SNDRIS) 21. Which antidepressant should be avoided when weight is undesirable a. b. c. d. Mirtazapine Trazodone Bupropion Amitriptyline

22. What is the best treatment of uncomplicated diaper rash

ZnO

23. Poriasis is Silvery white and red patches that form scales 24. Steven Johnso( a. rash b. skin peeling

25. vertigo with meniers (infection of inner ear)disease ----Gentamycin for vertigo, Low salt diet and Diuretics (Acetazolamide) 26. streptococcal meningitis is best treated with --------- Ampicillin + Gentamycin 27. All of them are used for HIV EXCEPT a. Efavirenz b. Trizivir c. Tenofovir

d. Acyclovir
28. Traponema pallidum----------- chancre(Ulceration in early stage of syphilis) & syphilis_

29. Which drug mortality in heart failure a. Enapri; b. Captopril c. Digixon d. Amlodipine e. Propranolol 30. In prinzmetalm agina all of them are good choice EXCEPT a. CCB b. BBs c. ACEI d. Nitrates 31. Which is not a risk factor in Iron deficiency anaemia a. Pregnancy b. Gastric reflux c. Peptic ulcer d. Haemorrhage e. Surgery 32. Which is not risk factor in hyper urecemia a. hypertension b. Obesity c. Pulmonary disease Comments: Alcohol, atherosclerosis, diabetes, hyperlipidemia and hypertension, obesity, renal disease are among the risk factors of hyper urecemia

33. Define Ascitis ------ accumulation of fluid in peritoneal cavity 34. Evidence that DM exist , what blood glucose rate in fasting should be a. 5.2mmol/L 7.1mmol/L b. 7.1mmol/L -11.1mmol/L c. 8.5mmol/L - 10.0mmol/L d. 10.0mmol/L 12.1mmol/L 35. which structure is best used in lipid parenteral injections a. CMC b. Cholesterol c. Phospholipids 36. Aluminium Acetate is used as ------burrows solution

37. All of them are important in plasmid EXCEPT a. DNA b. Bacteria c. Eukaryotic d. Ligase e. Restriction enzymes 38. Acetominophen prolonge used will effect ------ hepatoxicity

39. Defroxamine mechanism , site of action with Fe + ----- chelating 40. Aromatic and chealting ------------- penicillamine 41. mouth ulcer is the S.E of methotraxate treated by folic acid 42. Major enzyme involved in the metabolism of drug CYP 3A4 43. Structure of which enzymes with acetaminophen ------ Glutathione conjugation

44. Glutathione consists -------------- Cystein, Glycein , Glutamic acid 45. Which substance directly protects cell integrity ----------- Vit. E , Glutathione

46. Excipient that may cause diarrhea -------- Mg Stearate 47. Which subs may induce diarrhea----------mg stearate

48. Megaloblastic anemia is due to deficiency ------------ folic acid 49. Incorrect regarding Hcl EXCEPT a. kill bacteria b. Kills C.difficle (anaerobic) 50. Fe absorption can be by Vit.C 51. Nystatin (antifungal for diaper rassh) ergosterol associated with --------------- cell lysis 52. Phenols are most likely metabolised ------ Glucoronidation

53. Which is not a Phase II reaction --a. sulfoxidation b. N-acetylation

54. Which of these condition antithyroid drug is used for a. Grave disease b. cretinism c. myxedema 55. A physician in a unit dose hospital writes for Prednisone 15mg tid, each package contain 1 x 5mg tablets. How many package are needed per dose-------------------- if 1 pack 5mg then 3 pack contain 15mg, ----------- Ans : 3 56. A physician in a unit dose hospital writes for Prednisone 15mg tid, each package contain 1 x 5mg tablets. How many package are needed per day--------------------- if 1 pack is 5mg then 3 pack contain 15mg and for 3 days , 3 x 3 = 9Ans, ie 3pack in the morning , 3 pack in the noon and 3 pack in the evening 57. Prolong use of which drug may cause thrombocytopenia------- ibuprofen adverse effect NOT good for heart patient 58. Which drug may cause GI problem--------- Indomethacin 59. Cox II inhibitor is least likely cause -------- GI problem 60. Tubular reabsorption of weak base ---- what is NOT factor a. PH of urine b. pka of drug c. rate flow of urine d. metabolism e. lipid solubility 61. Define hypertrophy------ enlargement of organ OR Tissue 62. Gout patient which drug is NOT preferred-------------acetominophan (NSAID) 63. One with milk allergy is allergic to what----a. protein b. lactose

64. Which of the following is ARR--------

65. On a long flight what should be counsel a. Dont drink tap water b. Dont eat large meals c. Dimenhydrinate is effective in motion sickness 66. Emesis resulted from Narcotic is due to a. Direct effect on GI b. Stimulation of CTZ 67. Which opioid receptors are involved in pain a. meu

68. Chemistry of one of Ach analogue can inhibitor with enzyme------- Ach cholinesterase 69. structure of Purine analog 70. Esomeprazol & omeprazole relationship ----------------------- PPIs 71. Cimetedine ---------------- not used in allergic reaction 72. Silver sulfasalazine ------what is in the structure that makes it not absorbable?

Azo Bond
73. What is substituted in penicillin that makes it long acting ------- amide group? 74. Cephalosporin structure---------------- CH2 -N I I CH2 C = O 75. SAR ( structure activity relationship) of ciprofloxacin a. presence of F atom b. presence of CH2 group also contain COOH group 76. nasal absorption what is wrong a. using of peptides b. large surface increases systemic absorption c. large volume need preservatives

77. Which is NOT a cranial bone a. b. c. d. e. f. Frontal Ethmoid Occipital Sphenoid Hyoid (Tongue bone) Maxial(face bone)

78. Which one of the following is a least emetogenic drug a. cyclophosphamide b. doxirubicine c. tamoxifine d. rosiglitazone e. bleomycin 79. Patient Not respond to drug what will you give

80. Urinary incontinency in women which is not effective a. progesterone

b. Estrogen
c. oxybutin(Ist Line) d. impramine( in children) e. tolterodrine( Ist line)

(also used)

81. Q about plan B 82. About correct OCP way 83. Regimen of plan B 84. What is controlling the cerebral blood flow a. PCO2 ( Partial pressure of co2) b. PO2 85. HCO3 is present in interstial fluid in higher conc ---------in plasma 86. Aminoglycoside are best to be taken in daily because t 1/2 12 hours their MOA is unknown
Note : post dose effect must be there

87.Clathromycin resemble with------------------Erthromycin

87. Drink a lot of water with a. sulfonamide b. alluporinal

88. Sufamethoxazole MOA---------- folate synthesis inhibitor 89. Cholesterol ------- chelate with which enzyme

a. aromatase

b.

epoxidase

c. hydroxilase d. 90. Defination DNA 90. Correct sequence of DNA T & RNA U ------ spironolactone

91. The drug that produce LEAST hypokalemia 92. Diarrhea in patient ---------------- due to

Statins

93. Rhabdomyolysis or myopathy (muscle disease) is S.E of ---------------statins

94. Theophylline C.I with -------------------- Cimetedine

95. Drugs least affected by hepatic microsomal enzymes------a. Penicillin b. erythromycin c. ketoconazole 96. GABA MOA is -----------------------97. Whish one of the following is a essential amino acid PTVTIMHALL 98. Primary protein is made up of amino acids linked by peptide bonds

99. Vit deficiency in smoker is----------------------- C 100. Dysopyramide MOA.......... Na ,< K 101.Status Epileptics treatment ------------------- IV Diazepam

102.Atropine ------------ophthalmic solution or suspension

103.hypertonic solution ---what is added to make it isotonic a. water b. Nacl c. NaoH d. CH3

104.Metformin is C.I in all EXCEPT a. Renal failure b. Adjuvant c. Insulin & obese Comment : Metformin is contraindicated in both renal and hepatic failure

105.rate limiting step in percutaneous absorption------ stratum corneaum 106. Structure of morphine what is important-----------P-Phenyl N-Alkyl moiety
Morphine Antagonist contains Ally Group

107. Rapid acting insulin , what is correct Taken 15 min before meal

108.what is correct regarding human insulin subs by others a. dose adjustment should be done for regular insulin 109.What is not first line therapy for T.B a. penicillin b. INH

110.Protein can be detected by

a. western Blotting
111.Asthma patient what is not used a. beta blockers b. bronchodilator

112.A terminally ill patient (liver disease) what is decrease a. clotting time b. AST c. ALT d. Albumin e. Billirubin

113.What is true regarding COPD a. co morbidity with asthma b. linked significantly with cigarettes c. LABA & SABA is non effective d. B-agonist is the same importance as in asthma 114.To reach CSS fast what characteristics of drug should be t 1/2 & renal clearance and liver metabolism

115.Which of the following (monoclonal antibody) used in therapy of metastatic breast cancer

116.Herceptin (trastuzumab) is a. treatment of HER 2 over expressing metastatic breast cancer b. Tumour necrosis factor alpha inhibitor c. Glycoprotein inhibitor d. Interleukin e. Interferon

\ 117. ADH leads to a. Pyurea(pus in urine) b. thirst c. osmolarity?

Decreased osmolarity of plasma causes decrease release of ADH Osmolarity is the measure of solute conc. Per litre.........ADH causes reabsorption of solute free water , hence the conc of solute increase in urine and decreases in plasma
118.DOC for pregnant in hypertension a. methyldopa

119.DOC for pregnant in diabetes a. Insulin

120.Nicotine replace therapy a. rotation of patch b. if sensitive to gum can use patches

121.All of them in type I DM EXCEPT a. Juvenile b. Obesity c. Keto acidosis

122.Which hepatitis can be chronic B, C & D

123.treatment for hep C is a. interferon

124.All of them are the S.E of clozapine a. agranulocytosis

125.Define lypholization----------- freez drug methods

126.P.O.S is ---------127.Best to asses inventory is ------------- turn over rate 128.Negotiation between union and employer is a. bargaining b. debate c. argumentation d. arbitration

129.which is NOT important in vaccination a. cleaning of hands b. cleaning of place c. 130.Abbreva (docosanol) is used for a. cough b. cold sore ( Topical Cream) c. decongestion d. allergy e. rosacea

131.A patient with cystic acne ,what is the best treatment-------isotretinoin 132.Cholycystitis is ------------inflammation of bladder 133.premenopause with osteoprosis which is inappropriate a. Vit. D b. Estrogens

c. Raloxifen since it aggravates hot flushes so dont start until menopause is

established..................ONLY IN POST MENOPAUSE

d. Fosamax

135. if a drug is 150mg ---CSS is 19 , if 300mg CSS will be -----52 134.What is correct a. enzymes liver is saturated b. albumin binding

135.what is saturated means For drug induced Parkinsons disease to treat Extra pyramidal symptoms 136.Ideal temp for suppositories is a. b. c. d. 30C 45 C 60C 15C

138. Cholestyramine which circulatory subs ------ All except Triglycerides 139. Embolism Def------------ moving blood clot 140. Atherosclerosis Def ------------- blood flow in arteries due to deveopement of atherosclerotic plaques

141. Blood is transported to liver through ------------- portal vein 142. a. b. c. Vaccine of pneumococcal is required every year every ten year once a life

142. Tetanus vaccine needed every a. ten years b. every year c. once a life

143. Diff between complicated and uncomplicated UTI can be recognized a. urgent need of urination b. turbid urine

144. a. b. c. d. 145. a. b. c.

Uncomplicated UTI sulfonc regimenis 1 Day 3 days If Complicated then 10 DAYS 10 days 14 days Turbohaler what is correct counselled for high dose drug sensitive to humidity one dose

Cotrimoxazole

146. Spacer used in turbohaler counselling a. clean with wet tissue b. Not with water

147. Angle bwtween liquid and solid is described as a. Wet ability

148. Tonicity --------- what is wrong a. it can be measured by freezing point depression Comments: It is a colligative property 149. cortisone ,what disease --------------- Addisons Disease 150. Pilocarpine produce -----------------------------miosis 151. Cycloplegia Definition ------------- pyralysis of eye muscles----ciliary muscles caused by anticholinergics

152. a. b. c.

Prophylatic therapy for endocarditis is required in all except previous exposed infection substituted valve post M.I

153. a. b. c.

One have sleep disorder you can advise all except sleep time regular exercise before bedtime dont sleep in the afternoon

154. a. b. c.

Second application for anti lice shampoo is required because ----eggs left new born left not clear very well

155. DEET ------------------------------------------counselling Avoid in eyes & mouth 156. Topical therapy for alopecia-------Minoxidil 157. a. b. c. d. All of these required safe disposal EXCEPT needle syringe lancet spatula

157. Abbreviation

cc means----------- with food

158. OU means---------------------------------- both eyes 159. ZnSO4 200mg displace with 50mg of coca butter base

160. In microcytic anaemia , what is wrong a. reduce volume of cell b. increase serum ferritin coz it decreases

158. What include CBC a. Hematocrit b. WBC c. RBC 159. Ca++ reabsorption occur in which part of nephron a. distal tubule\ b. convulated tubule c. loop of henle 161. Inflammatory bowl disease --------------------crohns disease 162. Peptic ulcer ---------------- h-pylori 163. Etiology Def----------causation 164. Large dose of antibiotic needed----------To overcome resistence

165. High dose from 50mg to 100mg a. there will be in fraction of elimination drug / unit time b. Vd

166. Diff between soft contact lense and gas rigidity lens a. less fragile b. high H2O content 167. Enzyme produce by bacteria ------ B- lactamase 168. Acid resistant penicillin is -----------cloxacillin it is also resistant to B-Lactamase 169. Which is a choice in therapy of -ve meningitis --------Penicillin G 170. Chemistry in structure of cortisone when C binds to O ----Hemiacetal

171. Precurser of vit D3 is --------- 7 dehydrocholestrol 172. Drug bound to ---acid Albumin 173. Drugs in O/W ---- partition coefficient ----- c of v 174. BMI = weight (in kg) / h ( in miter) If a person weight is 60 kg And height is 6ft

= SD / X

x 100

1 Meter= 3.3 ft I ft = 12inch 1 meter= 39.5 inch

BMI = 6ft x 12(inch) = 72 inch 180 / 100 = 1.8m BMI = 60 / (1.8)2 = 60 / 3.24 = 18.51
Ans

Note : orlistat is only given when BMI is more than 30 175. Phase I ------ also called functional Group metabolism or Mixed function Oxidase Metabolism 176. Which is reverseable MAO-I -----meclobemide

177. a. b. c. d.

Hemoglobin cannot carry O2 due to which reaction oxidation reduction 0 0

178. The plane that divide body into unequal left and right ----parasagital 179. Intra-thecal admin means ------------ In Spine

180. The particle of disperse phase have inherent stability, why? Because a. small surface are b. high surface area

181. Levigating agent is ------- mineral oil 182. Zero order ---------- slope ---- k in C 10 +10+10 +10 +10 zero order 25+50+75+ half life 183. Absolut risk reduction is ------------ARR = EER --- CER 184. Competitive inhibitor------------185. What decrease in elderly -----------Body lean mass

186. Major difference between plasma and interstitial fluid a. quantity of protein 187. 5 reductase inhibitor ------finastride-----BPH

188. Monitoring of hypothyroidism ------ Serum TSH assay

189. Orlistat----------------------intestinal lipase inhibitor

190. Phenytoin S.E --------gingival hyperplasia

191. A drug designed as patch The shelf life t 1/2 is one year the researcher should do what is shelf life or t1/2 os over one year 192. Haploid is --------- No. of chromosomes of gemed single set of chromosomes ,

Examples : sperm and ova

193. Which drug can not be use for chronic Spasticity ( multiple sclorisis) a. Dantroline b. Baclofen

c. Clonzepam

JANUARY 2009 (PART -2)

1. Angiogenesis means - Formation of blood vessels 2. Hypertrophy means Enlargement of cells by size rather than increase in number of cell 3. Cystitis means bladder inflammation 4. Sciatic nerve in all foot branch 5. All branch of cerebral except Hyoid 6. pOH of 0.1M NaOH find pH

pOH = -logOH pOH= -log0.1 = 1 pW = pH + pOH pH = 14 1 = 13

7. Antithyroid used for gravies disease 8. All cause anemia (bleeding) except GERD 9. H.pylori associated with peptic ulcer. 10. Which is not in duodenal lumen: - adrenal gland 11. DNA sequence is Adenine, Guanine, Cytosine, Thiamine or except Uracil 12. Active form of vit.D is 1,25-dihydroxycholecalciferol 13. Iron undergo with defiroxamin chelation reaction 14. Iron cause microcytic anemia 15. All are true about iron except- give for 12month 16. Which contain epithelial cell all except bile salts, sweat, milk, saliva, hydrochloric acid 17. OU means both eye 18. Haploid is one set of chromosome 19. P.O.S is point of sale 20. Fluticasone which is correct rinse mouth after use

21. Use disposal bags for all except razor blades 22. SNRI is venalfexine 23. Canada health cover all except - outpatient prescription 24. Major inhibitory neurotransmitter- GABA\ 25. Calculate gross margin in % Gross M= sales cost of good sales X 100
Sales

26. Calculate how many tablets required for family of 5people having malaria 5X6= 30tablets 27. All correct about Leukotrine except 1) product of arachidonic acid not lipooxygenase 2) treatment of chronic asthma 3) acute asthma 4)essential fatty acid (5) granulocyte cells (ans) 28. Restrictive endonuclease cleavage DNA at special site 29. Nystatin mechanism of action cell lysis or leakage of cells 30. Equilibrium between organic (oil) and water Ans partition coefficient 31. Calculate coefficient of variance given standard deviation and mean C.V. = Standard Deviation X 100 Means 32. Calculate ARR (Absolute Risk Reduction) 33. Ca++ is absorbed from PTH from distal tubule 34. Parental lipid emulsion need phospholipids 35. A person complains from the side effect of drug, patient told the doctor and doctor still give him the medication what pharmacist have to do talk to the doctor 36. Vitamin lack in smoker vitamin C 37. Vitamin D3 is hormone 38. LH & FSH are secreted from anterior pituitary gland 39. All are action of glutamine acid except 40. Proteins separated by western blotting 41. Megaloblastic anaemia is due to deficiency of vit. B12 and folic acid 42. Meningitis treated by ceftriaxone 43. Drugs highly bound albumin 44. Which highly bound to opoid (Delta) (enkepilin) 45. Which is responsible for muscle relaxing Ach with Nicotine 46. Indol is found in serotonin 47. Paralysis of ciliary muscle is cycloplegia

48. Alpha1 cause all except arteriodilation 49. Embolism is clotting of blood 50. Angina treated by all except diuretic 51. CHF include all except 52. Abundant Ion in plasma HCO3 53. Class I antiarrythmic due Na sensitivity 54. TSH from anterior pituitary gland 55.