THE DISSOLUTION STUDIESPREPARTION OF DISSOLUTION BUFFERS

D.LOHITHASU M Pharm

BUFFER PREPARATION
PH KH2PO4 NaOH TO MADE UP TO 1000 ml

Ph 5.8

6.804 gm

0.144 gm

To 1000 ml

Ph 6.8

6.804 gm

0.896 gm

To 1000 ml

Ph 7.2

6.804 gm

1.288 gm

To 1000 ml

Ph 7.4

6.804 gm

1.564 gm

To 1000 ml

DRUG NAME
ACCELOFENAC Lamda max=275 nm

DMISSOLUTION MEDIUM
7.2 PHOSPHATE BUFFER 900 ml

TYPE OF APPARATUS
PADDLE TYPE II IP

TIME PROFILE
10,20,30,45,60 min

PARACETMOL 243 nm
METFORMIN (GLYCIPHAGE) 221 nm IBUPROFEN 221 nm RIFAMPICIN 475 nm

5.8 PHOSPHATE BUFFER 900 ml

6.8 PHOSPHATE BUFFER

USP TYPE II PADDLE

PADDLE USP II PADDLE PADDLE

10,20,30,45,60 min

10,20,30,45,60 min

7.2 PHOSPHATE BUFFER 900 ml 0.1 N Hcl

10,20,30,45,60 min

USP TYPE I BASKET USP TYPE II PADDLE

10,20,30,45,60 min

ACETOAMINOPHEN 5.8 PHOSPHATE BUFFER 243 nm SULPHAMETHOXAZ OLE

10,20,30,45,60 min

0.2 M NaOH =173.5 ml=1.388 gm 0.2 M NaOH=1000 ml =8 gm 0.1 M NaOH=1000ml=4 gm 27.22 gm =1000 ml=0.2 M KH P0 6.804 gm=250 ml= ???
2

 Phosphate 7.2 preparation: 34.7 ml of 0.2 M sodium hydroxide+ 50 ml of 0.2 M pot.dihydrogen phosphate = to made up to 200 ml. 250 ml of 0.2 M sodium hydroxide+ 173.5 ml of 0.2 M pot.dihydrogen phosphate = to made up to 1000 ml.

 Amount of drug dissolved=test od/std od*std conc*dilution factor. Stock solution preparation: 10 mg of pure drug rifampicin is made to dissolve in little quantity of acetone and further it is diluted to 10 ml with dissolution medium in 10 ml vol flask.