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  • Perhitungan Dosis: (HOPE, 6 Ed. P. 326) (HOPE, 6 Ed. P. 608)

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    This document provides instructions for preparing a chloramphenicol palmitate suspension. It includes the following key details: 1) The adult dosage is 4 times daily at 5mL, with each 5mL containing 500mg of chloramphenicol palmitate. 2) A formula is presented to prepare 4 bottles (280mL total volume) of a 10% chloramphenicol palmitate suspension using various excipients like HPMC, sodium saccharin, simple syrup, propylene glycol, and preservatives. 3) The amounts of each ingredient to be weighed and added to achieve the total 280mL volume are listed, along with instructions to adjust the pH and add flavoring

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    This document provides instructions for preparing a chloramphenicol palmitate suspension. It includes the following key details: 1) The adult dosage is 4 times daily at 5mL, with each 5mL containing 500mg of chloramphenicol palmitate. 2) A formula is presented to prepare 4 bottles (280mL total volume) of a 10% chloramphenicol palmitate suspension using various excipients like HPMC, sodium saccharin, simple syrup, propylene glycol, and preservatives. 3) The amounts of each ingredient to be weighed and added to achieve the total 280mL volume are listed, along with instructions to adjust the pH and add flavoring

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    17 views3 pages

    Perhitungan Dosis: (HOPE, 6 Ed. P. 326) (HOPE, 6 Ed. P. 608)

    Uploaded by

    SULFA
    This document provides instructions for preparing a chloramphenicol palmitate suspension. It includes the following key details: 1) The adult dosage is 4 times daily at 5mL, with each 5mL containing 500mg of chloramphenicol palmitate. 2) A formula is presented to prepare 4 bottles (280mL total volume) of a 10% chloramphenicol palmitate suspension using various excipients like HPMC, sodium saccharin, simple syrup, propylene glycol, and preservatives. 3) The amounts of each ingredient to be weighed and added to achieve the total 280mL volume are listed, along with instructions to adjust the pH and add flavoring

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    of 3

    Perhitungan Dosis

    Dosis: 4dd 500-750mg p.c (OOP ed.6 hlm. 86)

    Dosis Dewasa 500mg/ 1x

    500𝑚𝑔 500𝑚𝑔
    =
    𝑥 5𝑚𝐿

    500𝑚𝑔. 5𝑚𝐿
    x = 500𝑚𝑔

    x = 5mL

    1x = 5mL

    Jadi, dosis untuk dewasa = 4 x sehari 5mL

    Kadar 500mg/5mL

    500𝑚𝑔 𝑥 𝑚𝑔
    = 60𝑚𝐿
    𝑥

    500𝑚𝑔. 60𝑚𝐿
    x = 5 𝑚𝐿

    x = 600mg
    = 6g
    6𝑔
    .100% = 10%
    60𝑚𝐿

    PENDEKATAN FORMULA

    No. Nama Bahan Jumlah Kegunaan


    1. Klorampenikol Palmitat 10% b/v Bahan aktif (FI V hlm. 690)
    2. HPMC 2,5% b/v Suspending agent (HOPE, 6th ed.
    p. 326)
    3. Natrium Sakarin 0,2% b/v Sweetening agent (HOPE, 6th ed.
    p. 608)
    4. Sirupus Simplex 25% b/v Sweetening agent (HOPE 6th ed.
    p. 703)
    5. Propilen Glikol 10% b/v Wetting agent, Pelarut Pengawet
    (HOPE 6th ed. p. 592)
    6. Methylparaben 0,015% b/v Pengawet (HOPE 6th ed. p. 441)
    7. Prophylparaben 0,01% b/v Pengawet (HOPE 6th ed. p. 596)
    8. Asam Phospat 0,248% b/v Dapar (FI V hlm. 1727)
    (KH2PO4)
    9. Garam Phospat 0,75% b/v Dapar (FI V hlm. 1727)
    (NaH2PO4)
    10. HCl 0,1N/NaOH 0,1N qs Adjust pH
    11. Oleum Aurantii qs Flavouring agent (Martindale 36
    p. 2357)
    12. Pasta Jeruk qs Colouring agent
    13. Aquadest ad 100% v/v Pelarut (HOPE 6th ed. p. 766 )

    I. PENIMBANGAN
    › Dibuat sediaan 4 botol (@60ml)
    60mL x 4 botol = 240mL
    240mL + (2% x 240mL) = 240mL + 4,8mL
    = 244,8mL
    244,8mL + (10% x 244,8mL) = 244,8mL + 24,48mL
    = 269,28mL ~ 280mL

    No. Nama Bahan Jumlah yang Ditimbang


    1. Klorampenikol Palmitat 10 g
    . 280mL = 28g
    100mL
    2. HPMC 2,5g
    . 280mL = 7g
    100mL
    3. Natrium Sakarin 0,2g
    . 280mL = 0,56g
    100mL
    4. Sirupus Simplex 25 g
    . 280mL = 70g
    100mL
    5. Propilen Glikol 10 g
    . 280mL = 14g
    100mL
    6. Methylparaben 0,015 g
    . 280mL = 0,042g
    100mL
    7. Prophylparaben 0,01 g
    . 280mL = 0,028g
    100mL
    8. Asam Phospat (KH2PO4) 0,2408 g
    . 280mL = 0,674g
    100mL
    9. Garam Phospat (NaH2PO4) 0,75 g
    . 280mL = 2,1g
    100mL
    10. HCl Pekat 2 tetes
    11. Oleum Aurantii 2 tetes
    12. Pasta Jeruk 10 tetes
    13. Aquadest ad 280mL

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