First Professional MBBS Degree Examination, August 2012 BIOCHEMIS !" PAPE! 2 ime# $ H!

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Answer all questions Draw diagrams whenever necessary

Essa' (10) 1. Describe the sources, RDA, biochemical functions and deficiency manifestations of vitamin D (2+1+5+2=10 S*ort essa's (2!5=10 2. Describe the salva"e #ath$ay of #urine nucleotide synthesis $ith its si"nificance. Describe the disorder associated $ith it. %. Describe the structure and functions of tR&A S*ort notes (5!%=15 '. Define metabolic acidosis 5. Define re#lication and mention four inhibitors of re#lication (. )arasmus *. )ention the functions of +inc ,. -ause and clinical features of acute intermittent #or#hyria Ans+er ,riefl' (5!2=10 .. Define nucleotide. Define t$o adenosine nucleotide derivatives 10. /oint mutation 11. &ame the liver function tests 12. 0unctions of biotin 1%. Define thalassemia and mention the different ty#es of thalassemia -i.e /re0ise ans+ers (5!1=5 1'. &ame t$o tumour su##ressor "enes 15. Define "enetic code 1(. &ame t$o hormones causin" increased levels of cyclic A)/ 1*. &ame the coen+yme re1uired for transamination reactions 1,. )ention the normal serum calcium level