Risk Factors

Cytokine – interleukin promotes synthesis of MMPs & suppresses synthesis of collagen & proteoglycans

Physiological Changes  of matrix degrading enzymes - metalloproteinases (MMPs)

OSTEOARTHRITIS Ashley Dean RNSG1263

Envionmental & Behavioral Obesity Occupational Repetitive Motion Repeated Trauma

Age & Sex

Genetics Congenital Abnormalities Hormone Disorders Gout Diabetes

 Collagen in
matrix

 Proteoglycans
in matrix

 chondrocytes  proteoglycans  collagen molecules
Overwhelming  of matrix degrading enzymes - metalloproteinases Fibrillation of cartilage Lifestyle changes Inflammation Erosion of cartilage Cracking of cartilage Cartilage matrix degradation Observable erosions to articular cartilage

Crepitus Stress fractures Localized inflammation Chronic inflammation Joint swelling Chronic gout Joint tenderness Difficulty walking Joint stiffness

Osteoarthritis
Difficulty climbing stairs Osteonecrosis

 Range of motion
Joint pain

Manifestations

Complications

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