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  • Osteoarthritis Pathophysiology

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    AlloiBialba
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    Osteoarthritis is a disease that causes breakdown of cartilage in the joints. It has several risk factors including age over 65, obesity, genetics such as a family history of gout, and joint deformities. The disease process involves injury to cartilage in the joints, exposure of subchondral bone, increased production of inflammatory cytokines, and abnormal accumulation of chondrocytes that leads to changes in the joint structure and function over time. Common symptoms include joint pain, stiffness, swelling, and reduced mobility.

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    osteoarthritis-pathophysiology

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    Osteoarthritis is a disease that causes breakdown of cartilage in the joints. It has several risk factors including age over 65, obesity, genetics such as a family history of gout, and joint deformities. The disease process involves injury to cartilage in the joints, exposure of subchondral bone, increased production of inflammatory cytokines, and abnormal accumulation of chondrocytes that leads to changes in the joint structure and function over time. Common symptoms include joint pain, stiffness, swelling, and reduced mobility.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    52 views1 page

    Osteoarthritis Pathophysiology

    Uploaded by

    AlloiBialba
    Osteoarthritis is a disease that causes breakdown of cartilage in the joints. It has several risk factors including age over 65, obesity, genetics such as a family history of gout, and joint deformities. The disease process involves injury to cartilage in the joints, exposure of subchondral bone, increased production of inflammatory cytokines, and abnormal accumulation of chondrocytes that leads to changes in the joint structure and function over time. Common symptoms include joint pain, stiffness, swelling, and reduced mobility.

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    OSTEOARTHRITIS

    Risk factors:
     Age (65 years old)
     Obesity of the Patient Polymorphism of GDF5 Joint
    vt Genetics (gout of Paternal gene vulnerability
    grandfather)
     Joint deformities (genu
    varum )
    Injury to the cartilage of
    the joints

    Joint matrix remodeling Exposure of the bone Increased production of Abnormal accumulation
    surface inflammatory cytokines of chondrocyte Macro and
    Microtrauma

    Chondrocyte
    Increase bone-to-bone Increased destruction of Abnormal bone formation
    proliferation
    contact during movement joint matrix Subchondral &
    Articular Remodeling

    Clustering of the
    Synovitis Osteophyte formation in
    proliferated Production of fracture the joint Microscopic structural
    chondrocyte gaps due to friction
    changes (bone &
    cartilage)
    Activation of pain
    nociceptors Thickening of the
    Thickening of the joint Synovial fluid subchondral plate
    matrix accumulation between
    friction gaps Altered gene
    Joint pain, redness expression
    and heat Ossification of the
    cartilage
    Joint swelling

    Gel phenomenon Uneven surface of the Altered function & load


    cartilage

    Stiffness of
    the joints Crepitus

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