Professional Documents
Culture Documents
TESTICULAR CANCER
• Most common solid malignancy in men ages 15 to 35 years
old.
• Most common presentation is an asymptomatic enlarging
intra-scrotal mass.
Curable but remember it is a cancer for young men.
RELATIONSHIP WITH UNDESCENDED TESTIS (UDT)
• Germinal dysplasia and genetic changes
There is relationship of testicular cancer with
undescended testis. The testis descends into the scrotum
very late in the gestation period. In fact, halos just before
panganak sila saka bumababa yung testis. The testis
does not go down due to germinal dysplasia and genetic
changes. This predisposes the patient an increased risk
for testicular cancer.
• 8x increased risk for cancer
• 8-9% of tumors have prior history of Undescended Testis
(UDT)
• Increased risk as well in normal contralateral testis
o 8% will develop tumor in contralateral testis if a tumor is
in the UDT.
• Orchidopexy (operation to bring down the undescended
testis into scrotum) does NOT decrease the risk, but
improves fertility and simplifies monitoring for future Figure 2: Lifted from PPT, this is what it looks like when you request
development of a mass, for ultrasound with color doppler. Ultrasound Shows Normal
If after 1 year after birth di pa din bumabagsak yung Testis. We can see the central tendon (white arrow). Color Doppler
bayag or undescended testicle pa din, do orchidopexy. allows us to visualize the blood supply. We can see the normal
Why do we do orchidopexy? pattern of lobulations.
It CANNOT change the increased risk for cancer kasi
nandyian parin yung germinal dyplasia. However, kung
ilalagay ang testes sa loob ng scrotum at nagcacancer,
madali siya madetect and could be diagnosed early.
• RPLN are the earliest extra-gonadal metastatic site. Figure 5: Testicular Cancer Stages lifted from PPT.
• Embryologic development of the testis and the kidneys
(mesonephric ducts) occur close to each other. Stage 1- Still in the testes
Stage 2- With lymph node involvement
• They have similar lymphatics and to some extent blood Stage 3- Distant lymph node involvement
supply. T Staging
• Thus, the lymphatic drainage of the testis are at the RPLN. pTx T cannot be assessed (Prior to Radical Orchiectomy)
pT0 No evidence of T (e.g., histologic scar in testis)
MANAGEMENT
pTis Intratubular germ cell neoplasia (carcinoma in situ)
• Basic principles of surgical management of testicular CA: pT1 Limited to the testis and epididymis, no
o Prevent contamination or seeding of the scrotum by vascular/lymphatic invasion.
tumor, upstaging it to T4 to avoid an inguinal LN pT2 Limited to the testis and epididymis with
metastasis which occurs relatively early. vascular/lymphatic invasion or tumor extending
through tunica albuginea with involvement of
Kasi you want to keep the contamination of the testis tunica vaginalis.
sa tunica lang (dun lang sa kanya), wag mong paabutin pT3 Invades the spermatic cord with or without
sa scrotum kasi pag natamaan yung scrotum biglang vascular/lymphatic invasion
upstage yan papangit agad prognosis niyan. N Staging
o Percutaneous scrotal incisions or biopsies are avoided. NX Regional lymph nodes cannot be assessed
NO No regional lymph node metastasis
o All access to the testis are done via the inguinal route. N1 LN mass <2 cm in greatest dimension or multiple
So we don’t stick the needle through the scrotum, lymph node masses, none >2 cm in greatest
what we do through anesthesia we pull the testis to the dimension.
inguinal area.
TREATMENT
Initial Treatment
• Radical Orchiectomy (aka Radical Inguinal or Inguinal
Orchiectomy) Incision is at the inguinal area. Figure 8: Seminoma Lifted from PPT
o Spermatic cord is dissected and mobilized down into the
external ring and scrotal chamber. • Can be pure or mixed
o Testis and tumor is pushed through the external ring, en • Most common type of testicular cancer
bloc into inguinal incision. • Pure seminoma generally has normal tumor markers.
• 20% of pure seminomas can have elevated Beta-hcg.
You can do tumor marker before the surgery and
normally, seminoma is normal tumor marker, pero kung
may elevation, most probably it is non-seminomatous.
• Mixed tumors can have elevated Alpha-Feto Protein.
• Very radiosensitive
• Also, quite chemo-sensitive
Most of the time, combined ang radiotherapy and
chemotherapy for the treatment of seminoma.
• Good prognosis
Mas madaling gamutin ang seminoma kaysa sa non-
Figure 6: Radical Orchiectomy lifted from PPT seminomatous.
Figure 7: Radical Orchiectomy (lifted from PPT), dissect the spermatic • Embroyonal CA, Yolk Sac tumor, Polyembryonal,
cord, immobilize it down to the external ring then push the scrotum Choriocarcinoma, Teratoma, etc
up para mag pop out yung testis into the inguinal incision. This is the • Responds well to chemotherapy but not with radiation
gubernaculum testis this is what keeps it in the scrotum (Red Arrow). • Elevated tumor markers (B-HCG, AFP)
So puputulin mo yan then divide that para ma reduce yung scrotum. Tumor marker get done before preop, pag inoperahan
mo tingnan mo kung babagsak.
• Retroperitoneal lymph node metastasis is common
Metastasis is more common in non-seminomas. Do a
dual CT scan of the abdomen to see the metastasis in
lymph nodes.
• Poor prognosis
RETROPERITONEAL LN DISSECTION
Figure 12: Renal Cell Carcinoma or Kidney Cancer lifted from PPT.
Figure 10: Retroperitoneal Lymph Node Dissection lifted from PPT
No need to memorize
Right testes (A), nodes to take out are paracaval, intra- Clear cell CA- most common
Sarcomatoid-worst prognosis
aortocaval, paraaortic, then on the same side of testes, obturator
node ang aalisin. Same goes sa left side (B). PRESENTATION:
Essentially you get all the lymph nodes except for the • Most common presentation is painless hematuria,
paraaortic (you leave this alone). You get the paracaval, intra- microscopic or gross.
aorta caval, common iliac and everything down. Hematuria could also be cause by UTI, kidney stones or
tumors. Lahat yan can present with hematuria. Kaya it is
important to determine the cause of hematuria.
• Classic Triad of Renal Cell CA:
o Painless hematuria
o Flank pain
o Abdominal mass
Bihira na lang itong symptom na to kasi nauunahan
na ng pagdiscover since andaming clearance for work
like UTZ, kitang kita agad na may mass.
Pag napapalpate mo na yung mass, ibig sabihin
malaki na talaga siya. Kidney is a retroperitoneal
organ, below the ribs. Kaya pag napalpate mo na siya
ibig sabihin sobrang laki na.
• Smoking is the only risk factor identified
• Classic “triad” is seen in only 10% of cases
• Most cases are caught due to advances & ubiquity of
Figure 11: Kocher Maneuver lifted from PPT ultrasonography.
• Various histologic subtypes include:
Kocher maneuver is a surgical maneuver to expose o Clear cell
structures in the retroperitoneum behind the duodenum and o Papillary (types I and II)
pancreas. First is to immobilize ang ascending colon then o Chromophobe
extend excision towards the Ligamentum Treitz para maiiswing o Collecting duct
o Unclassified forms
mo sa isang side yung lahat ng bituka. Bale dapat makikita yung
likod na part ng peritoneum. Then get all the lymph nodes. BENIGN SOLID RENAL TUMORS
This is transabdominal procedure; you have to expose the
great vessels, so it is like a trauma operation. You do the incision
at level of the ligament of Treitz right beside the inferior
mesenteric artery and vein.
RENAL CELL CARCINOMA
• A.K.A. - Hypernephroma, Adenocarcinoma of the
kidney, Internist’s Tumor.
• Malignancy of the renal epithelium that can arise from any
component of the nephron,
o Most are said to be from the proximal convoluted
tubule (PCT). Figure 13: Oncocytoma lifted from PPT
• Most are sporadic
o Some are hereditary or congenital factors may be Very few, very rare
involved. • Benign lesions, which are more commonly found when
• These frequently involve a germ line mutation in a tumor- small tumors are removed, include oncocytomas and
suppression gene angiomyolipomas.
o Such as Von Hippel-Lindau (VHL gene) Syndrome Oncocytoma, spokewheel appearance. Central tendon
which can have bilateral tumors. gap. Very distinct.
Sounds malignant but this is benign.
Angiomyolipoma, Angio = blood vessel; Myo = muscle;
RENAL CYSTS
METASTASIS
• Most common sites of metastasis are the retroperitoneal
lymph nodes, lungs but liver, bone, and brain also are
common sites of spread.
• 20-30% present already with metastatic disease.
• Tests for metastasis include Chest CT, Bone Scan & Liver
Function Tests.
Figure 18: TNM Staging (enlarged image at the appendix)
RADICAL NEPHRECTOMY
• Gold standard for the curative treatment of Renal cell
carcinoma
• Radical nephrectomy includes the kidney and upper urinary
tract plus:
o Gerota’s fascia
o Perirenal fat
o Ureter
o Adrenal gland (if the tumor is large grossly
involving the adrenal or if it is predominantly upper
pole)
Sa stage 1 and 2, kaya pang tanggalin completely. Figure 19: Bilateral Chevron Incision (Left Image), Radical
Pag nag extend beyond Gerota’s fascia or perinephric fascia Nephrectomy (Right Image)
which is a great barrier from infection, stage 3 na. Mahirap na
tanggalin. Bilateral Chevron incision (Left Image) following the contour
of the costal ribcages. Thoraco-abdominal incision so
Stage 4, meron ka na adjacent organ involvement.
pumapasok sa luob nang thoracic cage into the peritoneum, we
do this for large tumors that extend superiorly.
Kidney Position (Right Image) there is a broken table, para
may angle to push the kidney more superficially.
PARTIAL NEPHRECTOMY
Figure 21 Partial Nephrectomy lifted from PPT Figure 25 Partial Nephrectomy lifted from PPT
This one for large tumor, minsan di na nakukuha yan pero
For example, the encircled structure is a mid-portion this one kinaya first locate the vessels then ligate it, wedge
tumor so what we do here is locate the posterior the tumor then repair.
segmental artery ligate it in order to wedge the tumor then
dugtong ulit.
The pointed structure is a superior pole tumor, we can do
partial nephrectomy also.
RADICAL NEPHRECTOMY
Figure 38 Laparoscopic Radical Nephrectomy lifted from PPT Pagnatapyas na put it in the lap sac already in preparation
to exploralize.
Once madisplaced na ang ureter you can now go to the
pedicle or renal hilum.
ERECTILE DYSFUNCTION
Most common form of male sexual dysfunction.
• Erectile dysfunction is defined as the inability to
achieve and maintain an erection sufficient for
satisfactory sexual intercourse.
• Erection is a neurovascular event.
• Most common cause of ED is psychogenic.
• Erection is modulated by the parasympathetic NS.
Stress and performance anxiety will make ED worse.
• Similar to ejaculation which is modulated by the
sympathetic NS, stress and anxiety will cause
premature ejaculation.
Figure 45 Drugs for Erection and their MOA lifted from PPT
This illustrates only the pharmacodynamic of
drugs for erection and where their target action is Figure 48 Causes of ED lifted from PPT for larger image see
exerted. appendix
▪
Nitrate-based drugs used in
conjunction with PDE5Is are an
absolute contraindication:
Because nitrate-based drugs also
use the nitric oxide pathway.
In the history the first thing to ask is
what are the medications you are
currently taking.
• Sublingual nitroglycerin,
ISDN, ISMN, Amyl nitrate.
• Can produce a potentially
fatal sudden drop in blood
pressure.
▪ Alpha-adrenergic blockers
• Terazosin and Doxazosin,
especially Alfuzosin and
Tamsulosin have lesser
Figure 49 Sexual Health Inventory for Men (SHIM) lifted from interactions.
PPT for larger image see appendix TREATMENT: INTRACAVERNOUS INJECTION
para matunaw yung tablet at para mag spread minsan • Torsion patients usually have a congenital high
naiinip and napapagod na ang patient tapos tinatamad attachment of the tunica vaginalis, such that the testicle
na pagkatapos so this product is not so successful, but can rotate freely on the spermatic cord.
it is still available in the market.
• Known as a “Bell-Clap Deformity”
• The testicle lies transverse as opposed to a longitudinal
lie of the affected testes.
• This congenital abnormality is present in approximately
12% of males.
• Twists spontaneously on the spermatic cord, causing
venous occlusion and engorgement, with subsequent
arterial ischemia and infarction.
• Experimental evidence indicates that 720 degrees twist
is required.
• In neonates, the testicle frequently has not yet
descended into the scrotum, after which it becomes
attached within the tunica vaginalis.
o This increased mobility of the testicle
Figure 52 Vacuum Erection Device lifted from PPT predisposes it to torsion (extravaginal
testicular torsion)
So this is a very classical device and very effective way
to sustain an erection. It has penile ring that should be
put first, then put the suction device. So ang gagawin
ng device na ito hihilain niya ang penis ng patient to
have a suction effect sa cavernous to have a very good
blood flow. So pag okay na put out the suction tube
since may penile ring na nakakabit sa penis ni patient
it will prevent the backflow of blood by that sustaining
the erection.
UROLOGIC EMERGENCIES
ACUTE SCROTUM
• “Acute Scrotum” is the urologist’s counterpart of the
General Surgeon’s “Acute Abdomen”
• Both conditions are guided by similar management
principles.
• Management:
o The mainstay for acute scrotum is history and
physical examination.
o Imaging merely complements, and will NOT
replace good clinical judgement. Figure 53 Normal Location of Testis lifted from PPT
o When in doubt, EXPLORE! Normally, the testis is embedded in tunica vaginalis
• Causes of Acute Scrotum kaya hindi talaga iiktot yan. Yung tunica vaginalis na
o Ischemia tinuturo diyan ay nagseserve as shock absorber and
o Trauma
nag cocool down sa bayag kasi ang gusto nga naten
o Infectious
o Inflammatory ay malamig na bayag kasi for fertility purposes.
▪ Scrotal wall Heinrech-Scholein
purpura (HSP), Fat Necrosis
o Hernia
▪ Incarcerated, Strangulated; with or
without testicular ischemia.
o Acute on Chronic Events
▪ Rupture/hemorrhage/infection of
Spermatocele, Hydrocoele,
Testicular Tumor
o Markedly Symptomatic Varicocele
TORSION (ISCHEMIA)
• When the testicle spontaneously twists thus
obstructing the blood supply, causing necrosis and Figure 54 Location of Testis lifted from PPT
pain.
A. normal location di magrorotate yan.
• The testicle is normally adherent to the tunica vaginalis
on the postero-medial aspect, thus limiting the twisting B. ito medyo magrorotate ito
movement. C. ito magrorotate talaga ito
TREATMENT
• It is better to explore a testis unnecessarily than to
neglect to do so when needed.
AGAIN, WHEN IN DOUBT EXPLORE!
• Best results are obtained when exploration is done
within 4-6 hours of the incident.
• >12 hours, testicular atrophy is significant.
Pag more than 12 hours usually makikita mona itim na
so pag ganon mag orchiectomy kana lang.
• If >24 hrs or with no improvement after detorsion,
orchiectomy or orchidectomy is done.
Even if may konting improvement, pag more than 24
hours wala ng detorsion, orchiectomy agad kasi baka
mamatay din eventually, you’ll have dead tissue then Figure 65: UTZ. Arrow is pointing to the testicular
mag abscess yun and result to sepsis. appendage that is edematous. Lifted from PPT.
• An orchidopexy or orchiopexy is ALWAYS performed
on the contralateral as the “Bell-Clapper Deformity” is
usually bilateral.
You would suture the testis to the tunica vaginalis
posteriorly, otherwise baka yung contralateral testis
naman ang magtorsion
• If the testis is to be preserved, an orchidopexy is also
performed.
• Orchidopexy is done by anchoring the tunica albuginea
of the testis to the overlying parietal tunica vaginalis
and scrotal dartos muscle.
• Some patients can have “Intermitted Torsion”, a
Figure 66 Color Doppler study showing no blood supply to
bilateral prophylactic orchidopexy can be done. the testicular appendage pointed by arrow while there is
"Intermittent" testicular torsion is a well-recognized entity in hyperemic LE (Left epididymis) and LT (Left Testis)
which a classic torsion history is obtained, but physical
examination and ultrasound findings are normal. TREATMENT
Intermittent torsion – sumasakit ung testis then • The process is often self-limited, with the infarcted
nawawala spontaneously. Don't wait for it to be full appendage undergoing atrophy with time.
blown testicular torsion, mag orchidopexy kaagad. for most cases, self-limiting. Just give antibiotics.
TORSION OF TESTICULAR OR EPIDIDYMAL • If exploration is pursued, the appendage is simply
APPENDAGES excised and no orchidopexy is needed.
• Small polypoid appendages are often found attached to the can appear as an acute scrotum so sometimes it is
testis or epididymis and are either Mullerian or Wolffian duct more prudent to do exploration.
remnants. FOURNIER’S GANGRENE
• Can also present with the acute onset of scrotal pain and
mass.
• The testis is palpable and has a normal lie(longitudinal).
• When examined early, the edematous, torsed appendage
can often be palpated at the upper pole of the testis.
• If the torsed appendage is ecchymotic, it can usually be
seen through the skin and represents the "blue-dot
sign."
Sometimes may makikita na kulay blue
• Scrotal wall infections may result from infected sebaceous EPIDIDYMITIS & EPIDIDYMOORCHITIS
cysts, folliculitis, or other dermatologic conditions. Epididymitis progressed to epididymoorchitis
Starts as parang pimple then nangati, kinamot lang, o Most of the time due to retrograde infection which
nagkagalos, diabetic yung patient then nag gangrene. comes from the urine, enters vas deferens to the
• Fasciitis of scrotum and groin, termed Fournier’s gangrene, epididymis then eventually mainvolved yung testis to
involves a rapidly progressive, life threatening infection of become epididymoorchitis.
the genital soft tissues. o It is very rare to have pure orchitis, kung meron man
• Associated with predisposing issues including urethral due to blood borne staphylococcus infection or TB.
perforation and periurethral abscess and is most often seen • Differential when patient presented with acute scrotum, very
in the immunocompromised or diabetic patient. common.
• Diffuse enlargement, thickening and erythema of the scrotal
• May be difficult to distinguish from scrotal trauma or testis
wall, groin, and perineum.
torsion.
• There may be necrotic black or ecchymotic patches of
• However, treatment is medical.
genital skin present.
Antibiotics lang yan and pain reliever
• The most diagnostic is the finding of crepitus, a spongy,
cracking feeling within the skin that indicates gas- • Affects males of virtually all ages.
producing microorganisms that is methane underneath that • Usually results from the spread of infection from the
can be felt in the scrotum or perineum. An early sign of bladder, urethra, or prostate via the ejaculatory ducts and
fournier’s gangrene vas deferens into the epididymis.
Crepitus – pag hinawakan mo ang skin parang may ETIOLOGY
cellophane sa ilalim ng skin. • Infectious: Sexually transmitted Disease, UTI, Bladder
In patients with uncontrolled DM, more sugar, more Outlet Obstruction, BPH
• Non-Infectious: Adverse drug reaction, Urinary reflux in
microorganisms that will then produce methane gas
that would insinuate under the skin producing crepitus. ejaculatory ducts, sperm fluid extravasation from
vasectomy or blunt trauma
• When left untreated, can progress over more hours and • In boys, related to UTI and/or underlying GU congenital
result in overwhelming bacterial sepsis with an associated
high mortality rate. anomaly
TREATMENT • In elderly men, BPH and associated stasis, UTI, and
catheterization is the most common cause of epididymitis.
• Therefore, broad spectrum antibiotics that cover aerobic
and anaerobic organisms, and urgent and repeated surgical • Bacterial prostatitis and/or seminal vesiculitis are
drainage and debridement are required to control the associated with epididymal infection in postpubertal males
infection. of all ages.
Repeated surgical drainage and debridement – • STDs for younger men <35 y/o
halos araw araw ang surgery, you keep doing it until • Can progress to involve the orchitis as well, becoming
kulay pink, walang mabaho at malinis na malinis. “epididymo-orchitis”
• Incision and drainage with gauze packing and broad- • Most common organisms:
spectrum antibiotics are prescribed for these superficial o Coliforms or bacteriuria organisms
conditions. o For younger men <35 y/o heterosexuals, usually N.
• Aggressive treatment is mandatory even for superficial gonnorhea and C. trachomatis
conditions since these can easily progress. o For homosexual men, usually E. coli and H. influenzae
o Mycobacteria
Especially for patients with Diabetes and
o Viral, Fungal, Mycoplasma or parasitic but very rare.
immunosuppressed like HIV and transplant patient.
DIAGNOSIS
Result from any kind of purulent infection in the
perineum in the elderly male in the scrotum but can • PE: localizes the tenderness to the epididymis.
happen in women as well. • Most patients at the time of presentation will have testicular
involvement in the inflammatory process with pain,
epididymoorchitis.
• Spermatic cord is usually tender and swollen.
• Pain starts early in the tail of the epididymis, later involving
its entirety, with edema, epididymitis can become so large
that it can be indistinguishable from the testis.
• Primary goal initially is to distinguish between and
epididymoorchitis and testicular torsion.
• (+) Prehn’s sign
On PE, the affected hemiscrotum is elevated. This
action relieves the pain of epididymitis but
Figure 68: Fournier’s Gangrene Figure 69: Fournier’s Gangrene. exacerbates the pain of torsion.
CT scan showing gas packets as • Torsion will have a transverse lie.
pointed by the white arrow. • Later stages, more difficult to distinguish clinically.
ISCHEMIC PRIAPRISM
• Most common.
• Urologic emergency.
• The penis is very tender and both cavernosal bodies will be
rigid while the glans will be flaccid.
• In the normal erection, there is decreased venous outflow
with persistent arterial inflow resulting in increased
intracorporal pressure, followed by the release of venous
outflow & subsequent tumescence.
• With ischemic priapism, release of venous outflow is
impaired, erection is thus prolonged. Figure 78: Using a big bore needle, puncture the apex of
• Decreased or absent bladder contractility. cavernous body so there would be communication between
cavernous body and glans.
TREATMENT
• Thus, the basic principle in the management of priapism is
rapid detumescence with the goal of preservation of
erectile function.
• Preservation of erectile function requires that the
cavernous bodies be reperfused by oxygenated blood.
• Insertion of a g18 into the lateral aspect of one corporal
body allows aspiration of hypoxic/thrombosed blood with
alternate irrigation with saline. Figure 80: Sometimes, gagawin yung shunt sa
• Injection of dilute phenylephrine or epinephrine can help. may shaft. Make an incision between corpus
Would cause vasoconstriction.
spongiosum and cavernosa, make longitudinal
incisions then isuture parang arteriovenous
• Initially, dark venous blood is aspirated, later bright red
fistula
blood is a good sign.
Replace venous with NSS.
• SURGICAL MANAGEMENT
o Problem is the inability of the blood in the cavernous
bodies to exit.
o Goal of surgery is to “shunt” the blood out of the
cavernous bodies, most commonly into the corpus
spongiosum.
NON-ISCHEMIC PRIAPRISM
PARAPHIMOSIS
• Foreskin emergency.
• Completely different from “phimosis”
Figure 85: You can also do a dorsal slit para bumitaw
• Usually iatrogenic.
o Iatrogenic when medical professionals fail to unretract ang constriction ring
the prepuce after examination or instrumentation EMPHYSEMATOUS PYELONEPHRITIS
• When the foreskin or prepuce is retracted for prolonged • Life-threatening infection that results from a complicated
periods, constriction of the glans may ensue. pyelonephritis by gas-producing organisms.
• With constriction, venous backflow is restricted, edema of • Acute necrotizing infection in the kidneys seen usually in
the glans can happen which worsens the outflow. diabetic patients.
• Ischemia can ensue. • Patients usually present with sepsis & ketoacidosis.
• Escherichia coli is the most common organism.
APPENDIX
Appendix 1 Causes of ED