Predisposing factors:

Open wounds/
vascular insufficiency fractures
disorders
genitourinary infections
Microorganisms gain entry
respiratory infections
by way of blood
IV drug use
immunocompromising
diseases Microorganisms lodge into
history of blood- stream an area where circulation
infections slows
Indwelling prosthetic
devices
Microorganisms grow

Increase
pressure

Vascular compromise fever, night sweats,

Ischemia of the periosteum
chills, restlessness,
nausea and malaise
Infection through the bone constant bone pain,
cortex and marrow swelling, tenderness,
warmth at the infection site,
Cortical restricted movement
devascularization of the affected part

Debridement necrosis

Formation of new bone Separation of devitalized

bone from living bone Sequestra

Involcrum Continues to be an
infected island

Difficulty to reach by
blood borne antibiotics

Chronic Enlarged sequestrum

stage

Development of sinus Sequestrum move

drainage from
sinus tracts tract out to the soft tissue

Turns to scar
tissue revascularized
Systemic signs may
be diminished with Site for continued Removal by the normal
microorganism growth immune process
constant bone pain,
Swelling, tenderness,
warmth at the infection Remission and Healing
site exacerbation

Excessive vascular
insufficiency

Loss of organ
Amputation
function