Ionizing Radiation Higher energy electromagnetic waves (gamma) or heavy particles (beta and alpha). High enough energy to pull electron from orbit.
Non-ionizing Radiation Lower energy electromagnetic waves. Not enough energy to pull electron from orbit, but can excite the electron. Visible light, microwave
Ionizing radiation damage the cell constituents either directly or indirectly (generation of aqueous free radicals and related reactive species by radiolysis of water) Effects of radiation on biological system Deterministic Effect Stochastic Effect BIOLOGICAL Dominant Recessive SOMATIC GENETIC (all stochastic) Partial exposure - Hematopoietic - I ntestinal - Skin - Lung Whole body exposure - BM, GI and CNS syndrome Carcinogenic effect Hereditary effect Molecular Responses to Ionizing Radiation DNA: The primary cellular target Gene Mutations in Somatic Cells Genomic Instability Cell Cycle Effects Biological membranes-the alternative target
Bystander Effects
Biological effects of radiation exposure
Two categories - Deterministic effects Stochastic effects.
Deterministic Effects
Hemopoietic Syndrome
Gastrointestinal Syndrome
Central Nervous Syndrome
Other Acute Effects - Skin, Eyes, etc.
Biological effects of radiation exposure Radiation Syndrome Organs Affected Sensitivity Radiation Dose (Gy) Hematopoietic Blood forming organs Most sensitive 2-7 Gastrointestinal Gastrointestin al system Very sensitive 6< Central Nervous System Brain and muscles Least sensitive 20< Testes temporary sterility in men 0.3 ovaries temporary sterility in women 3
Eyes acute conjunctivitis Few Gy Biological effects of radiation exposure
Stochastic effects
Cataract
Damage to immune system
Cancer
Heredity effects
Uses of Radiation In medicine as diagnostic X-rays Radiopharmaceuticals for diagnosis and treatment Radiation therapy for cancer Sterilizing medical equipment and food products, etc. In locating oil and minerals in the earth Processing semiconductor chips for computers Nuclear power reactors for energy generation Determining age of materials through radiocarbon dating
Widespread use of radiation - increased the exposure of living beings to radiation (diagnosis, therapy, industry, energy sector, air and space travel, nuclear accidents and nuclear terror attacks, etc.)
For beneficial use of radiation, the risks of radiation exposures are to be restricted.
Basic concepts of radioprotection Time Distance Shielding Radioprotector - a chemical or a drug that reduces the damaging effects of radiation when administered to living organisms. Protect personnel from radiation-induced lethality and chronic diseases
Manage nuclear battlefield personnel exposed to ionizing radiation
Protect personnel involved in clean-up operations in nuclear accidents
Attenuate radiation effect in nuclear/chemical or nuclear/biological exposure scenarios
Need for a Radioprotector Radioprotector
Compounds/Formulations - reduce radiation damages in normal tissues. Clinically accepted molecule: Amifostine Slightly toxic at relevant doses. Ideal radioprotector is still an elusive dream. Need for a non-toxic, over the counter, cheap, orally administerable radioprotector. Plant extracts, phytoceuticals, ayurvedic formulations, etc. are being screened. Radioprotectors are thought to protect cells by
scavenging free radicals
producing hypoxia
temporarily inhibiting DNA synthesis, allowing time for the repair enzymes to complete repair of damage
forming disulphide bonds in proteins, thereby strengthening them